12 research outputs found
Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy
The Fc-alpha receptor (Fc alpha R/CD89) is involved in IgA complex formation and may affect the development of IgA nephropathy (IgAN). In this study, we tested the genetic variations of the CD89 gene in relation to disease susceptibility in IgAN and the expression of soluble CD89 (sCD89) in sera of patients with IgAN and in controls. There was a significant difference between the levels of sCD89-IgA complexes, measured by sandwich enzyme-linked immunosorbent assay (ELISA), in 177 patients with IgAN with and without disease progression at the time of first diagnosis. No such difference was found in 42 patients with other renal diseases. The patients with IgAN without disease progression had stable but high levels of sCD89 over 5-15 years of follow-up in contrast to stable but low levels of sCD89 in the disease progression group. Moreover, levels of sCD89 complexes were correlated with one of the five CD89 genetic variants in 212 patients with IgAN and 477 healthy Caucasians; the single-nucleotide polymorphism (SNP) rs11084377 was significantly associated with a lower expression of sCD89. However, no association between CD89 gene polymorphisms and susceptibility to IgAN was detected. Thus, we found an association between the levels of sCD89-IgA complexes in serum and the severity of IgAN, and a possible genetic component in regulating the production or expression of sCD89. Kidney International (2010) 78, 1281-1287; doi:10.1038/ki.2010.314; published online 1 September 201
A comparative, Randomized trial of Concentration-Controlled Sirolimus Combined With Reduced-Dose Tacrolimus or Standard-Dose Tacrolimus in Renal Allograft Recipients
The clinical safety and efficacy of sirolimus plus reduced-dose tacrolimus
was evaluated in de novo renal allograft recipients enrolled in a comparative, open-label
study.
Methods. One hundred twenty-eight renal allograft recipients were randomly assigned
(1:1) to receive reduced-dose tacrolimus plus sirolimus (rTAC) or standard-dose
tacrolimus and sirolimus (sTAC) for 6 months. The primary efficacy endpoint was
calculated creatinine clearance values at 6 months.
Results. Demographic variables were similar between groups. At 6 months, mean
( standard deviation) calculated creatinine clearance was significantly improved in the
rTAC group (63.8 vs 52.7 mL/min, P ÂĽ .005), although mean serum creatinine values were
not significantly different. Patient survival (95.2% and 96.9%) and graft survival (93.7%
and 98.5%) were similar between the rTAC and sTAC groups, respectively. Acute rejection
rates were 17.5% with rTAC and 7.7% with sTAC (P ÂĽ .095).
Conclusions. The rTAC regimen provided effective immunosuppression and was associated
with improved creatinine clearance. Adequate immunosuppressant exposure must
be achieved in the early postoperative period to minimize the risk of acute rejection
A randomized multicenter trial of the anti-ICAM-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation:a report of the European Anti-ICAM-1 Renal Transplant Study Group
Modelling of the operation of a Dual Mass Flywheel (DMF) for different engine-related distortions
Influence of pretransplant dialysis modality on the change of lymphocyte subset populations and acute rejection rates after renal transplantation
Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
SCOPUS: ar.jinfo:eu-repo/semantics/publishe