“One More for Luck”: The Destruction of U971 by HMCS Haida and HMS Eskimo, 24 June 1944

On the evening of 23 June 1944, HMCS Haida and HMS Eskimo set out from Plymouth, operational base of the 10th Destroyer Flotilla (10th DF), to conduct a sweep of the Western Approaches to the English Channel. Their role was to assist in securing these waters for the ongoing delivery of supplies and reinforcements to the Normandy bridgehead. Across the Channel to the southest, American, British and Canadian forces were now in their third week of fighting across the fields and hedgerows of Normandy. Operation OVERLORD had been the largest amphibious invasion in history and, dependent as it was on the unimpeded use of the sea, required an intensive concentration of air and naval forces to protect Allied supply convoys. This naval counterpart of OVERLORD was Operation NEPTUNE, and it was as part of this massive undertaken that Haida and Eskimo now steamed out of Plymouth

Model selection via Bayesian information capacity designs for generalised linear models

The first investigation is made of designs for screening experiments where the response variable is approximated by a generalised linear model. A Bayesian information capacity criterion is defined for the selection of designs that are robust to the form of the linear predictor. For binomial data and logistic regression, the effectiveness of these designs for screening is assessed through simulation studies using all-subsets regression and model selection via maximum penalised likelihood and a generalised information criterion. For Poisson data and log-linear regression, similar assessments are made using maximum likelihood and the Akaike information criterion for minimally-supported designs that are constructed analytically. The results show that effective screening, that is, high power with moderate type I error rate and false discovery rate, can be achieved through suitable choices for the number of design support points and experiment size. Logistic regression is shown to present a more challenging problem than log-linear regression. Some areas for future work are also indicated

Anticipatory Self-Defense and Other Stories

We argue that the specious justification for the invasion of Iraq -- a war based on a pretext of anticipatory self-defense -- necessarily exacerbates the inherent tendency of war to dehumanize and humiliate the enemy. This tendency is particularly evident in the variant of anticipatory self-defense that we have denominated as capacity preemption, a type of claim that by definition depends upon characterizations of the opponent as utterly inhuman. The Bush Doctrine tells a timeless story of self-defense. This story is shaped by an identifiable and predictable narrative structure, one that is able to transform the morally outrageous -- an unprovoked aggressive war -- into the legally reasonable. Utilizing the theoretical tools of anthropological structuralism, our analysis examines the rhetorical use of the anticipatory self-defense narrative to veil hidden agendas of domination and conquest

The Role of Cold Flows and Reservoirs in Galaxy Formation With Strong Feedback

We examine gas accretion and subsequent star formation in representative galaxies from the McMaster Unbiased Galaxy Simulations (Stinson et al. 2010). Accreted gas is bimodal with a natural temperature division at $10^5$ K, near the peak of the cooling curve. Cold-mode accretion dominates inflows at early times, creating a peak in total accretion at redshift z=2-4 and declining exponentially below z$\sim$2. Hot-mode accretion peaks near z=1-2 and declines gradually. Hot-mode exceeds cold-mode accretion at z$\sim$1.8 for all four galaxies rather than when the galaxy reaches a characteristic mass. Cold-mode accretion can fuel immediate star formation, while hot-mode accretion preferentially builds a large, hot gas reservoir in the halo. Late-time star formation relies on reservoir gas accreted 2-8 Gyr prior. Thus, the reservoir allows the star formation rate to surpass the current overall gas accretion rate. Stellar feedback cycles gas from the interstellar medium back into the hot reservoir. Stronger feedback results in more gas cycling, gas removal in a galactic outflow and less star formation overall, enabling simulations to match the observed star formation history. For lower mass galaxies in particular, strong feedback can delay the star formation peak to z=1-2 from the accretion peak at z=2-4.Comment: 10 pages, 7 figures. Accepted for publication in MNRA

How states make their own air pollution somebody else’s problem

For now, one of the unfortunate byproducts of an industrial economy is air pollution, but states can often reap the benefits of industry and production while forcing other states to bear the costs. In a new study of tens of thousands of air polluters in the US, James E. Monogan III, David M. Konisky, and Neal D. Woods find that air polluters are more likely to be located near a downwind border compared to solid waste polluters; in effect, making air pollution another state’s problem

Differential Responsivity of the Hypothalamic-Pituitary-Adrenal Axis to Glucocorticoid Negative-Feedback and Corticotropin Releasing Hormone in Rats Undergoing Morphine Withdrawal: Possible Mechanisms Involved in Facilitated and Attenuated Stress Responses

Chronic morphine treatment produces profound and long-lasting changes in the pituitary-adrenal responses to stressful stimuli. The purpose of the present study was to explore the mechanisms involved in these altered stress responses. Chronic morphine administration increased basal plasma concentrations of corticosterone and adrenocorticotropic hormone (ACTH), which peaked at 36 h after the final morphine injection and returned to normal levels within 84-h. Whole brain glucocorticoid receptor protein expression was reduced (approximately 70%) in morphine-treated rats 4-h after the final morphine injection and these levels recovered within 16-h. Twelve hours following morphine withdrawal, rats displayed normal ACTH, but potentiated and prolonged corticosterone responses to restraint stress. Both the ACTH and corticosterone responses to restraint in acutely withdrawn rats were insensitive to dexamethasone. Furthermore, acutely withdrawn rats displayed reduced ACTH but prolonged corticosterone responses to peripheral corticotropin releasing hormone (CRH) administration. These findings suggest that the normal ACTH and enhanced corticosterone responses to stress in acutely withdrawn rats involved decreased sensitivity of negative-feedback systems to glucocorticoids, reduced pituitary responsivity to CRH, and enhanced sensitivity of the adrenals to ACTH. Eight days following morphine withdrawal, rats displayed dramatically reduced ACTH, but normal corticosterone responses to restraint stress. These rats displayed enhanced sensitivity to dexamethasone and normal pituitary-adrenal responses to CRH. These data suggest that the reduced ACTH responses to stress in 8-day withdrawal rats involved increased sensitivity of negative-feedback systems to glucocorticoids as well as reduced CRH and/or AVP function in response to stress. Taken together, the results of this study illustrate some of the mechanisms mediating altered stress responsivity in rats that have received chronic morphine treatment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73727/1/j.1365-2826.2001.00714.x.pd

Assessing Unit‐Price Related Remifentanil Choice In Rhesus Monkeys

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96725/1/jeab.2006.108.05.pd