Optimal designs for multivariable spline models

In this paper, we investigate optimal designs for multivariate additive spline regressionmodels. We assume that the knot locations are unknown, so must be estimated from thedata. In this situation, the Fisher information for the full parameter vector depends on theunknown knot locations, resulting in a non-linear design problem. We show that locally,Bayesian and maximin D-optimal designs can be found as the products of the optimaldesigns in one dimension. A similar result is proven for Q-optimality in the class of allproduct design

Large volume continuous counterflow dialyzer has high efficiency

Dialyzer separates macromolecules from small molecules in large volumes of solution. It takes advantage of the high area/volume ratio in commercially available 1/4-inch dialysis tubing and maintains a high concentration gradient at the dialyzing surface by counterflow

Experimental Issues for Precision Electroweak Physics at a High-Luminosity Z Factory

We discuss the ultimate precision for ALR, and therefore for the weak mixing angle, at a high-luminosity Linear Collider. Drawing on our experience at the SLC, and considering various machine parameter sets for the NLC and for TESLA, it emerges that a compromise between peak luminosity and precision will be a likely outcome. This arises due to the severe requirements on the uncertainty in the luminosity weighted collision energy (Ecm). We consider the cases with and without a polarized positron beam.Comment: Submitted to LCWS2000 (Linear Collider Workshop 20000), Fermilab, 10-24-200

Evidence-Based Psychosocial Treatments for Pediatric Body-Focused Repetitive Behavior Disorders

Habits, such as hair pulling and thumb sucking, have recently been grouped into a category of clinical conditions called body-focused repetitive behavior disorders (BFRBDs). These behaviors are common in children and, at extreme levels, can cause physical and psychological damage. This article reviews the evidence base for psychosocial treatment of pediatric BFRBDs. A review of academic databases and published reviews revealed 60 studies on psychosocial treatments for pediatric BFRBDs, 23 of which were deemed suitable for review. Based on stringent methodological and evidence base criteria, we provided recommendations for each specific BFRBD. Individual behavior therapy proved probably efficacious for thumb sucking, possibly efficacious for several conditions, and experimental for nail biting. Individual and multicomponent cognitive-behavioral therapy was named experimental for trichotillomania and nail biting, respectively. No treatment met criteria for well-established status in the treatment of any BFRBD. Recommendations for clinicians are discussed. Reasons for the limitations of existing research in children and adolescents are explored. Several recommendations are presented for future pediatric treatment research on BFRBDs

Continuous countercurrent dialysis of large volumes

Dialyzer for continuous countercurrent dialysis of large volume

Technological learning: towards an integrated model

The acquisition and growth of technological knowledge is fundamental to competitive advantage in the emerging knowledge economy. This article explores the notion of technological learning as a means of developing the capabilities that underpin long term sustainable innovation. The research project was designed to identify new ways of understanding learning in the context of technology-driven SMEs, so the methods employed were essentially inductive in nature. This has resulted in the development of a comprehensive framework comprising four inter-related knowledge categories (Identity, Direction, Capability, and Relationship), each of which has an associated learning process (learning by reflecting, learning by strategising, learning by doing, and learning by interacting). We argue that it is the interaction between these knowledge categories that generates the new insights that are essential to technological learning