47 research outputs found
Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II
In this article, we describe developments in the field of clinical allergy as described by Clinical and Experimental Allergy in 2018; epidemiology, asthma and rhinitis, clinical allergy and allergens are all covered.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153257/1/cea13535.pd
Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146621/1/cea13318.pd
Galactose-α-1,3-GalactoseâSpecific IgE Is Associated with Anaphylaxis but Not Asthma
Rationale: IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract
Expansion of CD4+CD25+ and CD25- T-Bet, GATA-3, Foxp3 and RORÎłt Cells in Allergic Inflammation, Local Lung Distribution and Chemokine Gene Expression
Allergic asthma is associated with airway eosinophilia, which is regulated by
different T-effector cells. T cells express transcription factors T-bet, GATA-3,
RORÎłt and Foxp3, representing Th1, Th2, Th17 and Treg cells respectively. No
study has directly determined the relative presence of each of these T cell
subsets concomitantly in a model of allergic airway inflammation. In this study
we determined the degree of expansion of these T cell subsets, in the lungs of
allergen challenged mice. Cell proliferation was determined by incorporation of
5-bromo-2âČ-deoxyuridine (BrdU) together with 7-aminoactnomycin (7-AAD).
The immunohistochemical localisation of T cells in the lung microenvironments
was also quantified. Local expression of cytokines, chemokines and receptor
genes was measured using real-time RT-PCR array analysis in tissue sections
isolated by laser microdissection and pressure catapulting technology. Allergen
exposure increased the numbers of T-bet+,
GATA-3+, RORÎłt+ and
Foxp3+ cells in CD4+CD25+
and CD4+CD25- T cells, with the greatest expansion of
GATA-3+ cells. The majority of
CD4+CD25+ T-bet+,
GATA-3+, RORÎłt+ and
Foxp3+ cells had incorporated BrdU and underwent
proliferation during allergen exposure. Allergen exposure led to the
accumulation of T-bet+, GATA-3+ and
Foxp3+ cells in peribronchial and alveolar tissue,
GATA-3+ and Foxp3+ cells in perivascular
tissue, and RORÎłt+ cells in alveolar tissue. A total of 28
cytokines, chemokines and receptor genes were altered more than 3 fold upon
allergen exposure, with expression of half of the genes claimed in all three
microenvironments. Our study shows that allergen exposure affects all T effector
cells in lung, with a dominant of Th2 cells, but with different local cell
distribution, probably due to a distinguished local inflammatory milieu
Distinct Human T Cell Repertoires Mediate Immediate and Delayed-Type Hypersensitivity to the Trichophyton
Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy
In the second of two linked articles, we describe the development in clinical as described by Clinical & Experimental Allergy and other journals in 2019. Epidemiology, clinical allergy, asthma and rhinitis are all covered. In this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2019. Epidemiology, clinical allergy, asthma and rhinitis are all covered.</p
Developments allergy in 2019 through the eyes of clinical and experimental allergy, part I mechanisms
In the first of two linked articles, we describe the development in the mechanisms underlying allergy as described by Clinical & Experimental Allergy and other journals in 2019. Experimental models of allergic disease, basic mechanisms, clinical mechanisms and allergens are all covered.</p