677 research outputs found
Leveraging Uncertainties to Infer Preferences: Robust Analysis of School Choice
Inferring applicant preferences is fundamental in many analyses of
school-choice data. Application mistakes make this task challenging. We propose
a novel approach to deal with the mistakes in a deferred-acceptance matching
environment. The key insight is that the uncertainties faced by applicants,
e.g., due to tie-breaking lotteries, render some mistakes costly, allowing us
to reliably infer relevant preferences. Our approach extracts all information
on preferences robustly to payoff-insignificant mistakes. We apply it to
school-choice data from Staten Island, NYC. Counterfactual analysis suggests
that we underestimate the effects of proposed desegregation reforms when
applicants' mistakes are not accounted for in preference inference and
estimation
Clinical Characteristics and Genotypes of Rotaviruses in a Neonatal Intensive Care Unit
BackgroundThere are few reports on the symptoms of rotavirus infections in neonates. This study aims to describe clinical signs of rotavirus infections among neonates, with a particular focus on preterm infants, and to show the distribution of genotypes in a neonatal intensive care unit (NICU).MethodsA prospective observational study was conducted at a regional NICU for 1 year. Stool specimens from every infant in the NICU were collected on admission, at weekly intervals, and from infants showing symptoms. Rotavirus antigens were detected by enzyme-linked immunosorbent assay (ELISA), and genotypes were confirmed by Reverse transcription-Polymerase chain reaction (RT-PCR). The infants were divided into three groups: symptomatic preterm infants with and without rotavirus-positive stools [Preterm(rota+) and Preterm(rotaā), respectively] and symptomatic full- or near-term infants with rotavirus-positive stools [FT/NT(rota+)]. Demographic and outcome data were compared among these groups.ResultsA total of 702 infants were evaluated for rotaviruses and 131 infants were included in this study. The prevalence of rotavirus infections was 25.2%. Preterm(rota+) differed from Preterm(rotaā) and FT/NT(rota+) with respect to frequent feeding difficulty (pĀ =Ā 0.047 and 0.034, respectively) and higher percentage of neutropenia (pĀ =Ā 0.008 and 0.011, respectively). G4P[6] was the exclusive strain in both the Preterm(rota+) (97.7%) and FT/NT(rota+) (90.2%), and it was the same for nosocomial, institutional infections, and infections acquired at home.ConclusionSystemic illness signs such as feeding difficulty and neutropenia are specific for preterm infants with rotavirus infections. G4P[6] was exclusive, regardless of preterm birth or locations of infections. This study might be helpful in developing policies for management and prevention of rotavirus infections in NICUs
Citizen Engagement in Smart City Planning: The Case of Living Labs in South Korea
The smart city is recognized as a new city model for inclusive urban planning. Many local governments are making smart city plans to develop new policies that manage urban issues in South Korea. They identify issues through citizen surveys and decide which issues should be managed with priority. Some governments test developed policies based on citizen engagement. Most local governments use the living labs to encourage citizen engagement in smart city plans since these are public spaces where planners engage citizens to develop innovative and inclusive ideas. This study conducted a content analysis of smart city plans of local government. We analyzed the various approaches to the living lab and examined the stage of the planning process it is utilized in. Additionally, we identified the barrier to the living lab by interviewing people who participated in the smart city plan. According to the analysis, a barrier to citizen engagement exists in smart city plans; most citizen engagement is only used when planners develop ideas for setting visions and goals. It implies that citizen engagement occurs at a limited level in smart city plans and may cause planning to be less inclusive. We suggest that citizen engagement should be considered in the whole planning process to improve the inclusiveness of smart city plans and encourage sustainable citizen engagement
Cosmesis and feasibility of transvaginal natural orifice Specimen extraction (NOSE) for large organ specimen: a prospective pilot study
This study aimed to evaluate cosmetic outcomes and feasibility of transvaginal natural orifice specimen extraction (NOSE) in patients who underwent laparoscopic or robotic surgery for the treatment of benign or malignant diseases of the kidney, liver, stomach, adrenal gland, and bladder.
Methods
This prospective study was conducted at a tertiary hospital between March 2015 and May 2020. The main outcome was cosmetic outcomes of scars assessed using the Patient and Observer Scar Assessment Scale (POSAS) 1 and 8 weeks after surgery. The secondary outcomes were postoperative pain, operating time, and complications. Sexual function was assessed using the Female Sexual Function Index (FSFI) questionnaire 6 months after surgery in 17 patients who were sexually active at the time of surgery.
Results
A total of 38 transvaginal NOSE procedures were performed for the extraction of 33 kidneys, 2 livers, 1 stomach, 1 adrenal gland, and 1 bladder. Observers rated pigmentation and relief scores as most deviant from normal skin (2.9āĀ±ā1.7, 3.0āĀ±ā2.1 at postoperative 1 week; 3.6āĀ±ā1.9, 3.5āĀ±ā2.2 at postoperative 8 weeks, respectively), but the overall scores of each item were low. The patients overall satisfaction with postoperative scars was high, and the mean scores for pain and itching were low, with significant improvement from the first week to the eighth week (Pā=ā0.014 and Pā=ā0.006, respectively). Patients also reported low scores on vaginal assessment items, indicating better symptoms, and bleeding improved significantly between the two time points (Pā=ā0.001). Postoperative pain was reduced from moderate during the first 24h after surgery to mild after 24h. The mean operative time of the transvaginal NOSE procedure was 28.3āĀ±ā13.3min. No postoperative complications were associated with the procedure. The mean FSFI total score was 21.2āĀ±ā8.7 (cutoff score for dysfunction is 21), with higher scores indicating better sexual functioning.
Conclusion
Transvaginal NOSE seems to be a feasible procedure with promising cosmetic benefits, for patients who undergo minimally invasive surgery for large organs including the kidney, liver, stomach, adrenal gland, and bladder. A prospective randomized clinical trial is needed to provide solid evidence to support transvaginal NOSE.
Trial registration:
This trial is registered at ClinicalTrials.gov (NCT05113134).This study was supported by a grant (no. 02-2014-0055) from the Seoul National University Bundang Hospital Research Fund. The funding source played no role in the study design, collection, analysis, or interpretation of the data, writing of the report, or decision to submit the article
Orthogonal Stability of an Additive-quartic Functional Equation in Non-Archimedean Spaces
Using fixed point method, we prove the Hyers-Ulam stability of the orthogonally additive-quartic functional equation f(2x+y)+ f(2x-y)=4 f(x+y)+ 4 f(x-y) + 10 f(x) + 14f(-x) - 3 f(y)-3f(-y) for all with , in non-Archimedean Banach spaces. Here is the orthogonality in the sense of RƤtz
Cell density-dependent differential proliferation of neural stem cells on omnidirectional nanopore-arrayed surface
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In vitro activity of gemifloxacin against recent clinical isolates of bacteria in Korea.
Gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. In Korea, resistant bacteria are relatively more prevalent than in other industrialized countries. In this study, we studied the in vitro activities of gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ciprofloxacin, and other commonly used antimicrobial agents against 1,689 bacterial strains isolated at four Korean university hospitals during 1999-2000. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method of National Committee for Clinical Laboratory Standards. Gemifloxacin had the lowest MICs for the respiratory pathogens: 90% of Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were inhibited by 0.06, 0.03, and 0.03 mg/L, respectively. Gemifloxacin was more active than the other fluoroquinolones against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci, streptococci, and Enterococcus faecalis. The MIC90s of gemifloxacin for Klebsiella oxytoca, Proteus vulgaris, and non-typhoidal Salmonella spp. were 0.25, 1.0, and 0.12 mg/L, respectively, while those for other Gram-negative bacilli were 4-64 mg/L. In conclusion, gemifloxacin was the most active among the comparative agents against Gram-positive species, including respiratory pathogens isolated in Korea
Extradigit Glomus Tumor Causing Abdominal Pain -A Case Report-
Glomus tumors are small vascular tumors that are usually benign and rarely occur. They originate from glomus bodies and present in the reticular dermis. They are clinically distinguished by their small size and their ability to cause extreme pain. Most of these tumors are subungually located. However, atypical locations of the tumors sometimes cause misdiagnosis, particularly when the lesion is rarely reported. Therefore, we report a case of glomus tumor which presented with chronic abdominal pain, found in the abdominal wall that has never been reported before
Combined Effects of Surface Morphology and Mechanical Straining Magnitudes on the Differentiation of Mesenchymal Stem Cells without Using Biochemical Reagents
Existing studies examining the control of mesenchymal stem cell (MSC) differentiation into desired cell types have used a variety of biochemical reagents such as growth factors despite possible side effects. Recently, the roles of biomimetic microphysical environments have drawn much attention in this field. We studied MSC differentiation and changes in gene expression in relation to osteoblast-like cell and smooth muscle-like cell type resulting from various microphysical environments, including differing magnitudes of tensile strain and substrate geometries for 8 days. In addition, we also investigated the residual effects of those selected microphysical environment factors on the differentiation by ceasing those factors for 3 days. The results of this study showed the effects of the strain magnitudes and surface geometries. However, the genes which are related to the same cell type showed different responses depending on the changes in strain magnitude and surface geometry. Also, different responses were observed three days after the straining was stopped. These data confirm that controlling microenvironments so that they mimic those in vivo contributes to the differentiation of MSCs into specific cell types. And duration of straining engagement was also found to play important roles along with surface geometry
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