FIBER SEPARATION USING INNOVATIVE CIRCULAR GRAVITY FLOTATION AND FIBER DETECTOR

Wang, LK, Wang, MHS, and Wong, JM (2019). Fiber separation using innovative circular gravity flotation and fiber detector. In: "Evolutionary Progress in Science, Technology, Engineering, Arts, and Mathematics (STEAM)", Wang, Lawrence K. and Tsao, Hung-ping (editors). Volume 1, Number 11, November 2019; 68 pages. Lenox Institute Press, Newtonville, NY, 12128-0405, USA. No. STEAM-VOL1-NUM11-NOV 2019; ISBN 978-0-9890870-3-2. ---------------ABSTRACT: The authors introduce the theories, principles, innovative engineering design, potential applications, and practical applications of circular gravity flotation process, a floated fiber detector , and many new inventions in this book in memory of Dr. Milos Krofta, who was the founder and the President of both the Lenox Institute of Water Technology (LIWT) and Krofta Engineering Corporation (KEC). Although specific LIWT/KEC process equipment are mentioned as typical examples or case histories, the authors are introducing the circular gravity flotation process, the circular gravity sedimentation process (using zero horizontal velocity concept), enclosed biological flotation, the fiber detector, etc. all in general terms forming a progress report in STEAM (science, technologies, engineering, arts, and mathematics) for benefiting both academic and engineering communities. Any researchers and equipment manufacturers are encouraged to follow the authors’ foot-steps, and develop or build their own similar process equipment, for similar applications

Paramaterizations of inclusive cross sections for pion production in proton-proton collisions. II. Comparison to new data

A set of new, precise data have recently been made available by the NA49 collaboration for charged pion production in proton-proton and proton-Carbon reactions at 158 GeV. The current paper compares this new data to five currently available arithmetic parameterizations. Although a precise fit is not expected, two of the parameterizations do not work very well but the other three are able to provide a moderately good, but not precise fit to the proton-proton data. The best two of these three parameterizations are scaled to the proton-Carbon data and again provide a moderately good, but not precise fit.Comment: 11 pages, 13 figures, Accepted for publication in Physical Review

Developing a feedback-rich culture in academic medicine: the effect of coaching and 360-feedback on physician leadership

Background: This is a time of unprecedented change in healthcare. More physicians are being tasked with stepping into a variety of leadership roles without having received the training needed to be an effective leader. Previous data have demonstrated the effectiveness of both leadership coaching and 360-feedback tools to foster physician well-being and leadership growth. In this proof of concept study, we explore the combined effect of these two tools. The objective of this study was to examine the effect of a brief physician 360 leadership coaching intervention on perception of professional dynamics and acquired leadership skills. Methods: Participants completed a tailored 360-feedback tool to gather input on their leadership skills, then engaged in five bi-weekly leadership coaching sessions. We conducted a post-intervention semi-structured qualitative interview. Qualitative data were coded using an inductive thematic analysis approach. Results: Twenty-three primary care physicians at an academic medical center engaged in the 360 leadership coaching study. Participants reported that the intervention yielded valuable benefits in five coaching sessions. Two overarching themes emerged: a Shift in leadership awareness and Navigating their environment. Leadership awareness included increased clarity of purpose and role, and recognition that routine feedback is critical to leadership development. Navigating their environment included gaining relationship-building communication, organizational awareness and navigation strategies. Conclusions: Combining a tailored 360-feedback tool with a five-session leadership coaching intervention provided physicians with valued support infrastructure for becoming more effective leaders. Physicians described a nuanced understanding of the leadership challenges physicians face, and identified the leadership tools needed to navigate the evolving healthcare delivery landscape. Curricula for physician leadership learning could consider this combination of a customized 360 plus targeted leadership coaching for training physician leaders

SCIENTIFIC STUDIES OF GLOBAL WARMING, CLIMATE CHANGE, GLACIER MELTING AND SALMON PROTECTION

Wong, Josephine O., Wang, Nai-Yi, Wang, Lawrence K. and Wang, Mu-Hao Sung (2019). Scientific studies of global warming, climate change, glacier melting and salmon protection. In: "Evolutionary Progress in Science, Technology, Engineering, Arts, and Mathematics (STEAM)", Wang, Lawrence K. and Tsao, Hung-ping (editors). Volume 1, Number 9, September 2019; 110 pages. Lenox Institute Press, Newtonville, NY, 12128-0405, USA. No. STEAM-VOL1-NUM9-SEP2019; ISBN 978-0-9890870-3-2. ------------ ABSTRACT: Scientific studies of global warming, climate change, glaciers melting and salmon protection conducted by international researchers are reviewed, presented and discussed. The topics covered in this book chapter include: technical terminologies, climate change, global warming, main contributors to greenhouse gases, global warming potential and its limitations, absorption of heat by carbon dioxide, rising temperature trend in the environment, land temperature rise, ocean temperature and its water level rise, glacier melting, glacier protection, tidewater glaciers, Glacier Bay National Park and Reserve, Mendenhall Glacier, Mendenhall Lake, salmon protection, salmon life cycle, fire frequency, carbon dioxide stabilization, actions for environmental protection, and Macaulay Salmon Hatchery, Alaska, USA

SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression

© 2015 Sin, Yung, Yip, Chan, Wong, Tam and Siu. Our current understanding on the molecular mechanisms by which sustained compression induces skeletal muscle injury is very limited. This study aimed to test the hypothesis that activation of SIRT1 by the natural antioxidant resveratrol could deactivate apoptotic and catabolic signaling in skeletal muscle exposed to moderate compression. Two cycles of 6-h constant pressure at 100 mmHg was applied to the tibialis region of right, but not left hindlimbs of Sprague Dawley rats pre-treated with DMSO (vehicle control) or resveratrol with/without sirtinol. Skeletal muscle tissues lying underneath and spatially corresponding to the compressed sites were collected for analyses. Resveratrol prevented the compression-induced manifestations of pathohistological damages including elevations of the number of interstitial nuclei and area of interstitial space and ameliorated oxidative damages measured as 4-hydroxy-2-nonenal (4HNE) and nitrotyrosine in skeletal muscle. In parallel, resveratrol augmented the expression level and activity of SIRT1 and phosphorylation levels of Foxo3a and Akt while suppressed the increases in protein abundances of p53, Bax, MAFbx, and ubiquitin, enzymatic activities of caspase 3 and 20S proteasome, and apoptotic DNA fragmentation in the compressed muscle. These favorable myoprotective effects of resveratrol were diminished upon pharmacological blockade of SIRT1 by using sirtinol. These novel data support the hypothesis that the anti-apoptotic and anti-catabolic effects of resveratrol on compression injury in skeletal muscle required the action of SIRT1.Link_to_subscribed_fulltex

The value of patient selection in demonstrating treatment effect in stroke recovery trials: Lessons from the CHIMES study of MLC601 (NeuroAiD)

© 2015 Chinese Cochrane Center, West China Hospital of Sichuan University and Wiley Publishing Asia Pty Ltd. Objective: The CHIMES Study compared MLC601 to placebo in patients with ischemic stroke of intermediate severity in the preceding 72 hours. We aimed to verify if patient selection based on two prognostic factors (ie, stroke severity and time to treatment) improves detection of a treatment effect with MLC601. Methods: Analyses were performed using data from the CHIMES Study, an international, randomized, placebo-controlled, double-blind trial comparing MLC601 to placebo in patients with ischemic stroke of intermediate severity in the preceding 72 hours. Three subgroups, that is, onset to treatment time (OTT) ≥48 hours; baseline National Institute of Health Stroke Scale (NIHSS) ≥10; both OTT ≥48 hours and baseline NIHSS ≥10, were analyzed using modified Rankin Scale (mRS) ≤1 and a composite endpoint of mRS ≤1, Barthel Index ≥95, and NIHSS ≤1 at month 3. Results: Placebo response rates were lower (ie, worse natural outcome) among subgroups with prognostic factors. Conversely, MLC601 treatment effects were significantly higher in the subgroups with prognostic factors than for the entire cohort, being highest among patients with both OTT ≥48 hours and baseline NIHSS of 10 to 14: odds ratios of 2.18 (95% CI 1.02 to 4.65) for month 3 mRS ≤1 and 3.88 (95% CI 1.03 to 14.71) for the composite endpoint. Conclusions: : Patients who have moderately severe strokes and longer OTT demonstrate better treatment effects with MLC601. These factors can guide patient selection in future trials.Link_to_subscribed_fulltex

Implications of MicroRNAs in the treatment of gefitinib-resistant non-small cell lung cancer

2015-2016 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The SAMI Galaxy Survey: Towards a unified dynamical scaling relation for galaxies of all types

We take advantage of the first data from the Sydney-AAO Multi-object Integral field (SAMI) Galaxy Survey to investigate the relation between the kinematics of gas and stars, and stellar mass in a comprehensive sample of nearby galaxies. We find that all 235 objects in our sample, regardless of their morphology, lie on a tight relation linking stellar mass ($M_{*}$) to internal velocity quantified by the $S_{0.5}$ parameter, which combines the contribution of both dispersion ($\sigma$) and rotational velocity ($V_{rot}$) to the dynamical support of a galaxy ($S_{0.5}=\sqrt{0.5V_{rot}^{2}+\sigma^{2}}$). Our results are independent of the baryonic component from which $\sigma$ and $V_{rot}$ are estimated, as the $S_{0.5}$ of stars and gas agree remarkably well. This represents a significant improvement compared to the canonical $M_{*}$ vs. $V_{rot}$ and $M_{*}$ vs. $\sigma$ relations. Not only is no sample pruning necessary, but also stellar and gas kinematics can be used simultaneously, as the effect of asymmetric drift is taken into account once $V_{rot}$ and $\sigma$ are combined. Our findings illustrate how the combination of dispersion and rotational velocities for both gas and stars can provide us with a single dynamical scaling relation valid for galaxies of all morphologies across at least the stellar mass range 8.5$<log(M_{*}/M_{\odot})<$11. Such relation appears to be more general and at least as tight as any other dynamical scaling relation, representing a unique tool for investigating the link between galaxy kinematics and baryonic content, and a less biased comparison with theoretical models.Comment: 6 pages, 4 figures. Accepted for publication in ApJ Letter

S100A8 and S100A9 Are Associated with Doxorubicin-Induced Cardiotoxicity in the Heart of Diabetic Mice

© 2016 Pei, Tam, Sin, Wang, Yung, Chan, Wong, Ying, Lai and Siu. Cardiomyopathy is a clinical problem that occurs in the hearts of type 2 diabetic patients as well as cancer patients undergoing doxorubicin chemotherapy. The number of diabetic cancer patients is increasing but surprisingly the cardiac damaging effects of doxorubicin, a commonly used chemotherapeutic drug, on diabetic hearts have not been well-examined. As the signaling mechanisms of the doxorubicin-induced cardiomyopathy in type 2 diabetic heart are largely unknown, this study examined the molecular signaling pathways that are responsible for the doxorubicin-induced cardiotoxicity in type 2 diabetic hearts. Male 14- to 18-week-old db/db mice were used as the type 2 diabetic model, and age-matched non-diabetic db/+ mice served as controls. The db/+ non-diabetic and db/db diabetic mice were randomly assigned to the following groups: db/+CON, db/+DOX-5d, db/+DOX-7d, db/dbCON, db/dbDOX-5d, and db/dbDOX-7d. Mice assigned to doxorubicin (DOX) group were exposed to an intraperitoneal (i.p.) injection of DOX at a dose of 15 mg/kg to induce cardiomyopathy. Mice in control (CON) groups were i.p. injected with the same volume of saline instead of DOX. Mice were euthanized by overdose of ketamine and xylazine 5 or 7 days after the DOX injection. Microarray analysis was adopted to examine the changes of the whole transcriptional profile in response to doxorubicin exposure in diabetic hearts. Ventricular fractional shortening was examined as an indicator of cardiac function by transthoracic echocardiography. The presence of diabetic cardiomyopathy in db/db mice was evident by the reduction of fractional shortening. There was a further impairment of cardiac contractile function 7 days after the DOX administration in db/db diabetic mice. According to our microarray analysis, we identified a panel of regulatory genes associated with cardiac remodeling, inflammatory response, oxidative stress, and metabolism in the DOX-induced cardiac injury in diabetic heart. The microarray results of selected genes were confirmed by real time PCR. Notably, S100A8 and S100A9 were found to have a unique specific expression pattern that was coincident with the DOX-induced cardiomyopathy in diabetic hearts. Correspondingly, NF-κB expression in diabetic hearts was increased together with the elevation of S100A8/9 and activation of p38 MAPK signaling after DOX administration, which induced cardiac inflammation as demonstrated by the elevation of cardiac IL-6 level. These findings provide novel pre-clinical information for revealing the S100A8/A9-associated molecular signaling pathways that mediate the doxorubicin-induced cardiotoxicity in diabetic hearts.Link_to_subscribed_fulltex