Influence of aggregate size and fraction on shrinkage induced micro-cracking of mortar and concrete

In this paper, the influence of aggregate size and volume fraction on shrinkage induced micro-cracking and permeability of concrete and mortar was investigated. Nonlinear finite element analyses of model concrete and mortar specimens were performed. The aggregate diameter was varied between 2 and 16 mm. Furthermore, a range of volume fractions between 0.1 and 0.5 was studied. The nonlinear analyses were based on a 2D lattice approach in which aggregates were simplified as monosized cylindrical inclusions. The analysis results were interpreted by means of crack width and change of permeability. The results show that increasing aggregate diameter (at equal volume fraction) and decreasing volume fraction (at equal aggregate diameter) greatly increases permeability.Comment: 12th International Conference on Fracture (ICF 12

Multi-pair massive MIMO relay networks: power scaling laws and user scheduling strategy

This study studies a multi-pair massive multiple-input multiple-output (MIMO) relaying network, where multiple pairs of users are served by a single relay station with a large number of antennas, and the amplify-and-forward protocol and zero-forcing (ZF) beamforming are used at the relay. The authors investigate the ergodic achievable rates for the users and obtain tight approximations in closed form for finite number of antennas. The rate performance and power efficiency are studied based on the analytical results for asymptotic scenarios, and the effect of scaling factors of transmit powers for users and relay are discussed. The closed-form expressions enable us to determine the optimal user scheduling which maximizes the ergodic sum-rate for the selected pairs. A simplified user scheduling algorithm is proposed which greatly reduces the average complexity of the optimal use pair search without any rate loss. Moreover, the complexity reduction for the proposed algorithm increases nonlinearly with the increase of the number of user pairs, which indicates that the simplified scheduling algorithm has notable advantages when the number of users is increased. The tightness for the analytical approximations and the superiority of the proposed algorithm are verified by Monte-Carlo simulation results

Synthesizing Multiple Stakeholder Perspectives on Using Virtual Reality to Improve the Periprocedural Experience in Children and Adolescents: Survey Study

Background: Virtual reality (VR) technology is a powerful tool for augmenting patient experience in pediatric settings. Incorporating the needs and values of stakeholders in the design of VR apps in health care can contribute to better outcomes and meaningful experiences for patients. Objective: We used a multiperspective approach to investigate how VR apps can be designed to improve the periprocedural experiences of children and adolescents, particularly those with severe anxiety. Methods: This study included a focus group (n=4) and a survey (n=56) of clinicians. Semistructured interviews were conducted with children and adolescents in an immunization clinic (n=3) and perioperative setting (n=65) and with parents and carers in an immunization clinic (n=3) and perioperative setting (n=35). Results: Qualitative data were examined to determine the experience and psychological needs and intervention and design strategies that may contribute to better experiences for children in three age groups (4-7, 8-11, and 12-17 years). Quantitative data were used to identify areas of priority for future VR interventions. Conclusions: We propose a set of ten design considerations for the creation of future VR experiences for pediatric patients. Enhancing patient experience may be achieved by combining multiple VR solutions through a holistic approach considering the roles of clinicians and carers and the temporality of the patient’s experience. These situations require personalized solutions to fulfill the needs of pediatric patients before and during the medical procedure. In particular, communication should be placed at the center of preprocedure solutions, while emotional goals can be embedded into a procedure-focused VR app to help patients shift their focus in a meaningful way to build skills to manage their anxiety

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.

Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respiratory infections in humans. Two glycoproteins coordinate the infection of host cells, an attachment protein (G), which binds to cell surface receptors, and a fusion (F) protein, which carries out the process of virus-cell membrane fusion. The G protein binds to ephrin B2/3 receptors, inducing G conformational changes that trigger F protein refolding. Using an optical approach based on second harmonic generation, we show that monomeric and dimeric receptors activate distinct conformational changes in G. The monomeric receptor-induced changes are not detected by conformation-sensitive monoclonal antibodies or through electron microscopy analysis of G:ephrinB2 complexes. However, hydrogen/deuterium exchange experiments confirm the second harmonic generation observations and reveal allosteric changes in the G receptor binding and F-activating stalk domains, providing insights into the pathway of receptor-activated virus entry.Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational changes in G and discuss implications for receptor-activated virus entry

Constraint structure of O(3) nonlinear sigma model revisited

We study the constraint structure of the O(3) nonlinear sigma model in the framework of the Lagrangian, symplectic, Hamilton-Jacobi as well as the Batalin-Fradkin-Tyutin embedding procedure.Comment: 17 page

Clock synchronization with dispersion cancellation

The dispersion cancellation feature of pulses which are entangled in frequency is employed to synchronize clocks of distant parties. The proposed protocol is insensitive to the pulse distortion caused by transit through a dispersive medium. Since there is cancellation to all orders, also the effects of slowly fluctuating dispersive media are compensated. The experimental setup can be realized with currently available technology, at least for a proof of principle.Comment: 4 pages, 3 figure