The Injectable rhBMP-2-containing Collagen Gel for Tendon Healing in a Rabbit Extra-Articular Bone Tunnel Model

This rabbit animal study has a hypothesis that the collagen gel, which is injectable easily, can be an effective carrier for recombinant human bone morphogenetic protein 2 (rhBMP-2) for the tendon healing in a bone tunnel. The cut upper long digital extensor tendon of each rabbit was inserted into the proximal tibia bone tunnel, and rhBMP-2 conjugated collagen gel was injected into the tendon-bone tunnel interface using a syringe. Biomechanical and histological performances were analyzed at 3 and 6 weeks after surgery. The collagen sol at room temperature was transformed to a gel at 37°C. The rhBMP-2 was slowly released from the collagen gel for more than 4 weeks. The in vivo experiment showed the enhanced new fibrocartilage and bone tissue formation at 6 weeks after injecting the rhBMP-2-containing collagen gel. The calcification and enthesis-like tissue were detected radiologically in the repaired tendon-bone junction. The viscous collagen gel-containing rhBMP-2 increased the fusion rate of the repaired tendon in the bone tunnel. This study showed that viscous collagen gel can be an effective carrier for rhBMP-2 for tendon healing in the bone tunnel. The rhBMP-2-containing collagen gel will be promising for tendon-bone interface healing in the future

rhBMP-2-Coated Acellular Dermal Graft for Chronic Rotator Cuff Healing: Translational Tendon Repair Research

A rotator cuff tear is a common shoulder injury in sports medicine. However, a rotator cuff repair still has the high failure rate (57%) in large torn (>8 cm2) rotator cuff cases. One of the main reasons is failing at suture-tendon cause of continuous tensional and torsional stresses even after surgery, and thus, an ideal biologic augmentation to overcome large tears is an essential challenge. The ECM graft, the biological material can be useful for augment repair of large torn rotator cuff. Recombinant human bone morphogenetic protein 2 (rhBMP-2), which belongs to transforming growth factor-β superfamily, is well known as an osteoinductive growth factor. It plays an important role in the development of bone and cartilage. rhBMP-2 also facilitates chemotaxis in the host tissue. In this study, rhBMP-2-coated acellular dermal graft, which is isolated from human cadaveric donor, was transplanted in the rabbit with the chronic rotator cuff injury. The radiologic image, histomorphometric, histologic image analyses, and tensile test were performed to evaluate the effectiveness. The results showed the enhancement of increased host cell infiltration, new bone formation, and tensile mechanical property. The rhBMP-2-coated acellular dermal graft will be promising for chronic rotator cuff healing

Very short-term forecasting of precipitation based on hybrid surface rainfall technique in Korea

Póster presentado en: 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

Early Recurring Hepatocellular Carcinoma after Partial Hepatic Resection: Preoperative CT Findings

OBJECTIVE: The purpose of this study was to determine the utility of preoperative CT in predicting early recurrence of hepatocellular carcinoma after partial hepatic resection. MATERIALS AND METHODS: Preoperative three-phase helical CT scans in 53 patients with hepatocellular carcinoma were retrospectively reviewed by two radiologists. In 27 patients (group I), HCC had recurred within six months, while 26 (group II) had remained disease free for at least two years. In each group, preoperative CT findings were evaluated in each group for the tumor size and number, the presence or absence of capsule, distinctness of tumor margin, perinodular extension, and the presence or absence of portal vein thrombosis. RESULTS: In group I, a tumor capsule of tumor was seen in five of 27 patients (19%), and in group II, in 16 of 26 (62%) (p =.001). The tumor margin was distinct in eight patients (30%) in group I and in 20 (77%) in group II (p =.001). Multiple tumors, perinodular extension, and portal vein thrombosis were more frequently seen in group I but the differences were not statistically significant (p >.05). Tumor size was similar in each group (p >.05). CONCLUSION: Preoperative CT findings that may help predict the early recurrence of hepatocellular carcinoma after surgical resection are an absence of capsule of tumors and an indistinct margin. Reference to these findings during preoperative CT can guide clinicians in their choice of treatment.ope