Comparative analysis of the JAK/STAT signaling through erythropoietin receptor and thrombopoietin receptor using a systems approach

<p>Abstract</p> <p>Background</p> <p>The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is one of the most important targets for myeloproliferative disorder (MPD). Although several efforts toward modeling the pathway using systems biology have been successful, the pathway was not fully investigated in regard to understanding pathological context and to model receptor kinetics and mutation effects.</p> <p>Results</p> <p>We have performed modeling and simulation studies of the JAK/STAT pathway, including the kinetics of two associated receptors (the erythropoietin receptor and thrombopoietin receptor) with the wild type and a recently reported mutation (JAK2V617F) of the JAK2 protein.</p> <p>Conclusion</p> <p>We found that the different kinetics of those two receptors might be important factors that affect the sensitivity of JAK/STAT signaling to the mutation effect. In addition, our simulation results support clinically observed pathological differences between the two subtypes of MPD with respect to the JAK2V617F mutation.</p

Simultaneous Improvement in the Strength and Formability of Commercially Pure Titanium via Twinning-induced Crystallographic Texture Control

The rolling texture formed in the conventional cold rolling process of commercially pure titanium (CP-Ti) for producing a metal sheet significantly limits the potential applications of CP-Ti sheets in various industrial sectors by impairing the formability. Here, we report that by exploiting a twinning-induced crystallographic texture modification, the rolling texture can be weakened and dispersed effectively, leading to a simultaneous improvement in the formability and yield strength. A two-stage cold rolling process was designed with intermediate annealing at a late stage of the conventional cold rolling process to generate deformation twins. The intermediate annealing drove the activation of {11 (2) over bar2} twin and {11 (2) over bar2}-{10 (1) over bar2} double twin in the second stage of the rolling process by removing the internal reaction stress developed in the first stage of the rolling process through recrystallization, and the crystallographic feature of the {1122} twinned region, i.e., {11 (2) over bar2} twin texture, was effective for type slips and {10 (1) over bar2} twinning to accommodate a through-thickness strain as well as for reducing the planar anisotropy. This enhanced thinning capability and reduced planar anisotropy in the {11 (2) over bar2} twin texture led to an improvement of the formability. We demonstrated the feasibility of the suggested two-stage cold rolling process with ASTM grade 2 CP-Ti.11Ysciescopu

Analysis of import changes through shift-share, location quotient and BCG techniques: Gwangyang Port in Asia

The main aim of this article is to analyze the import changes of Gwangyang Port using shift-share, location quotient and BCG matrix techniques. We perform the standard shift-share analysis and spatial shift-share analysis for the period 2010–2018 and investigate the import performance of Gwangyang Port for coal, iron ore, natural gas and vegetable matter. The static analysis shows that the regional shift effect, which is the most important component, is negative for coal and iron ore, but positive for natural gas and vegetable matter. The spatial shift-share analysis also indicates that Gwangyang Port experiences not only the gains in regional competitiveness but the industrial advantage for iron ore, natural gas and vegetable matter owing to its higher competitiveness. Incorporating location coefficients into BCG matrix for coal imports, we also show that Gwangyang Port succeeds upgrading its position for natural gas and vegetable matter, but fails escaping from transformation category or upgrading its position for coal and iron ore

A Comparison of Perfect Table Cryptanalytic Tradeoff Algorithms

The performances of three major time memory tradeoff algorithms were compared in a recent paper. The algorithms considered there were the classical Hellman tradeoff and the non-perfect table versions of the distinguished point method and the rainbow table method. This paper adds the perfect table versions of the distinguished point method and the rainbow table method to the list, so that all the major tradeoff algorithms may now be compared against each other. Even though there are existing claims as to the superiority of one tradeoff algorithm over another algorithm, the algorithm performance comparisons provided by the current work and the recent preceding paper are of more practical value. Comparisons that take both the cost of pre-computation and the efficiency of the online phase into account, at parameters that achieve a common success rate, can now be carried out with ease. Comparisons can be based on the expected execution complexities rather than the worst case complexities, and details such as the effects of false alarms and various storage optimization techniques need no longer be ignored. A significant portion of this paper is allocated to accurately analyzing the execution behavior of the perfect table distinguished point method. In particular, we obtain a closed-form formula for the average length of chains associated with a perfect distinguished point table