Results of the ROC analysis.

<p>**AUC-ROC > 0,80.</p><p>*p < 0.005 in accordance with Bonferroni correction.</p><p>ROC = receiver-operating-characteristic, AUC = area under the curve, CI = confidence interval, MRI = magnetic resonance imaging, TLCRR = tumor-to-liver count-rate ratio, MN = metanephrine, VMA = vanillylmandelic acid, A = adrenaline, NA = noradrenaline, HVA = homovanillic acid, DP = dopamine, NSE = neuron-specific enolase.</p><p>Accuracy of several imaging parameters and tumor markers for prediction of unfavorable histopathology was tested by ROC analysis using Bonferroni correction for multiple comparisons. Corresponding AUC-ROC, p value and 95% CI are given.</p

ROC of TLCRR and serum NSE for prediction of unfavorable histopathology.

<p>Receiver-operating-characteristic (ROC) is given for TLCRR (dashed line) and serum NSE (continuous line). AUC-ROC was 0.86 for TLCRR. Optimal cut-off determined by the Youden index was 2.0 (*), resulting in a sensitivity of 68% and a specificity of 100%. AUC-ROC was 0.81 for serum NSE. Optimal cut-off was 25.8 ng/ml (**) with a sensitivity of 74% and a specificity of 85%. AUC-ROC = area under the receiver-operating-characteristic, TLCRR = tumor-to-liver count-rate ratio, NSE = neuron-specific enolase.</p

Urine catecholamine metabolite levels and serum NSE in patients with favorable histopathology (FH) and unfavorable histopathology (UH) according to the International Neuroblastoma Pathology Classification (INPC).

<p>Concentrations are given as mean ± standard deviation (SD). Difference was tested by unpaired Mann-Whitney test including Bonferroni correction for multiple comparisons (p < 0.005*). MN = metanephrine, VMA = vanillylmandelic acid, A = adrenaline, NA = noradrenaline, HVA = homovanillic acid, DP = dopamine, NSE = neuron-specific enolase.</p

Patient characteristics. INSS = International Neuroblastoma Staging System.

<p>Patient characteristics. INSS = International Neuroblastoma Staging System.</p

Performance of TLCRR, NSE and combined analysis for prediction of unfavorable histopathology.

<p>Sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and accuracy (AC) are each given in percent using optimal cut-off as determined by ROC analysis. Relative risk (RR) was calculated. TLCRR = tumor-to-liver count-rate ratio, NSE = neuron-specific enolase, ROC = receiver-operating-characteristic.</p