A Variational Approach to Particles in Lipid Membranes

A variety of models for the membrane-mediated interaction of particles in lipid membranes, mostly well-established in theoretical physics, is reviewed from a mathematical perspective. We provide mathematically consistent formulations in a variational framework, relate apparently different modelling approaches in terms of successive approximation, and investigate existence and uniqueness. Numerical computations illustrate that the new variational formulations are directly accessible to effective numerical methods

Urinary active transforming growth factor ß in feline chronic kidney disease

The cytokine transforming growth factor beta 1 (TGF-β1) has been widely implicated in the development and progression of renal fibrosis in chronic kidney disease (CKD) in humans and in experimental models. The aims of this study were to assess the association between urinary active TGF-β1 and (a) development of CKD in a cross-sectional study, (b) deterioration of renal function over 1 year in a longitudinal study, and (c) renal histopathological parameters in cats. A human active TGF-β1 ELISA was validated for use in feline urine. Cross-sectional analysis revealed no significant difference in urinary active TGF-β1:creatinine ratio (aTGF-β1:UCr) between groups with differing renal function. Longitudinally, non-azotaemic cats that developed CKD demonstrated a significant (P = 0.028) increase in aTGF-β1:UCr approximately 6 months before the development of azotaemia, which remained elevated (P = 0.046) at diagnosis (approximately 12 months prior, 8.4 pg/mg; approximately 6 months prior, 22.2 pg/mg; at CKD diagnosis, 24.6 pg/mg). In the histopathology study, aTGF-β1:UCr was significantly higher in cats with moderate (P = 0.02) and diffuse (P = 0.005) renal fibrosis than in cats without fibrosis. Cats with moderate renal inflammation had significantly higher urinary active aTGF-β1 concentrations than cats with mild (P = 0.035) or no inflammatory change (P = 0.004). The parameter aTGF-β1:UCr was independently associated with Log urine protein:creatinine ratio in a multivariable analysis of clinicopathological parameters and interstitial fibrosis score in a multivariable analysis of histopathological features. These results suggest that urinary aTGF-β1 reflects the severity of renal pathology. Increases in urinary aTGF-β1 followed longitudinally in individual cats may indicate the development of CKD

Chemical equilibration of quarks and gluons at RHIC and LHC energies

We study chemical equilibration of quarks and gluons in central nuclear collisions at RHIC and LHC energies. The initial quark and gluon densities are taken from earlier studies as well as from recent perturbative QCD estimates and are then evolved via rate equations coupled to longitudinally boost-invariant fluid dynamics. We find that, for RHIC initial conditions, the lifetime of quark-gluon matter is too short in order for the quark and gluon number densities to chemically equilibrate prior to hadronization. In contrast, at LHC energies chemical equilibration is complete before the system hadronizes. Entropy production due to chemical equilibration can be as large as 30%.Comment: 30 pages (latex2e), 13 postscript figures, corrected one figure, further analysis performed, to be published in NP

Advancing projections of phytoplankton responses to climate change through ensemble modelling

A global trend of increasing health hazards associated with proliferation of toxin-producing cyanobacteria makes the ability to project phytoplankton dynamics of paramount importance. Whilst ensemble (multi-)modelling approaches have been used for a number of years to improve the robustness of weather forecasts this approach has until now never been adopted for ecosystem modelling. We show that the average simulated phytoplankton biomass derived from three different aquatic ecosystem models is generally superior to any of the three individual models in describing observed phytoplankton biomass in a typical temperate lake ecosystem, and we simulate a series of climate change projections. While this is the first multi-model ensemble approach applied for some of the most complex aquatic ecosystem models available, we consider it sets a precedent for what will become commonplace methodology in the future, as it enables increased robustness of model projections, and scenario uncertainty estimation due to differences in model structures

Magnetic-field dependence of electron spin relaxation in n-type semiconductors

We present a theoretical investigation of the magnetic field dependence of the longitudinal ($T_1$) and transverse ($T_2$) spin relaxation times of conduction band electrons in n-type III-V semiconductors. In particular, we find that the interplay between the Dyakonov-Perel process and an additional spin relaxation channel, which originates from the electron wave vector dependence of the electron $g$-factor, yields a maximal $T_2$ at a finite magnetic field. We compare our results with existing experimental data on n-type GaAs and make specific additional predictions for the magnetic field dependence of electron spin lifetimes.Comment: accepted for publication in PRB, minor changes to previous manuscrip

2023 Community Based Care: Resident and Community Characteristics Report on Assisted Living, Residential Care, and Memory Care Communities

The Institute on Aging at Portland State University (IOA/PSU) presents findings from the ninth annual study of Oregon community-based care: assisted living and residential care facilities (AL/RC) with and without memory care endorsement (MC). In this year’s study, we included information about various resident, community, and staff characteristics, including: 1) Residents: sociodemographic characteristics (e.g., age, sex, race, ethnicity), length of stay, personal assistance, health conditions, status, service use, medications, and advanced care planning/legal documentation; 2) Communities: capacity, occupancy rates, resident move-in and move-out locations, private pay charges, Medicaid reimbursement to facilities, staffing, resident transportation use, COVID-19 impacts; and 3) Staff: type (e.g., RN, LPN, CNA, CMA, non-licensed or certified personal care staff), contract or agency staff, number of staff employed, benefits offered, ability to hire new staff, challenges to hiring new staff. The study was funded by the Oregon Department of Human Services

Simulating Dynamical Features of Escape Panic

One of the most disastrous forms of collective human behaviour is the kind of crowd stampede induced by panic, often leading to fatalities as people are crushed or trampled. Sometimes this behaviour is triggered in life-threatening situations such as fires in crowded buildings; at other times, stampedes can arise from the rush for seats or seemingly without causes. Tragic examples within recent months include the panics in Harare, Zimbabwe, and at the Roskilde rock concert in Denmark. Although engineers are finding ways to alleviate the scale of such disasters, their frequency seems to be increasing with the number and size of mass events. Yet, systematic studies of panic behaviour, and quantitative theories capable of predicting such crowd dynamics, are rare. Here we show that simulations based on a model of pedestrian behaviour can provide valuable insights into the mechanisms of and preconditions for panic and jamming by incoordination. Our results suggest practical ways of minimising the harmful consequences of such events and the existence of an optimal escape strategy, corresponding to a suitable mixture of individualistic and collective behaviour.Comment: For related information see http://angel.elte.hu/~panic, http://www.helbing.org, http://angel.elte.hu/~fij, and http://angel.elte.hu/~vicse

Electron Spin Relaxation in a Semiconductor Quantum Well

A fully microscopic theory of electron spin relaxation by the D'yakonov-Perel' type spin-orbit coupling is developed for a semiconductor quantum well with a magnetic field applied in the growth direction of the well. We derive the Bloch equations for an electron spin in the well and define microscopic expressions for the spin relaxation times. The dependencies of the electron spin relaxation rate on the lowest quantum well subband energy, magnetic field and temperature are analyzed.Comment: Revised version as will appear in Physical Review

A Fred Friendly Roundtable

Taking a different approach from the other panels in the Court of Public Opinion Conference, participants in the roundtable role-played their way through a hypothetical (though familiar-sounding) legal issue involving alleged sexual assault by a student athlete, sensitive issues of race and class, and high profile media attention. Moderator Jack Ford, a TV news veteran, assigns roles including defense attorney, District Attorney, reporter, and Chancellor to a large panel, and asks them to examine their various obligations and choices when faced with the unfolding controversy. Questions/themes/discussion topics When and how should university officials publicly address criminal investigations involving students? Do in-house investigations by universities of alleged criminal acts by students affect those students\u27 constitutional rights? How should university officials balance the rights of accused students with the safety of the rest of the student body? Television news\u27s reliance on personality over expertise Public statements by prosecutors and defense counse