5 research outputs found
Determination of forensically relevant SNPs in the MC1R gene
Abstract. Genetic prediction of physical appearance is a very attractive prospect for forensic investigations. The association between some genetic variants of the MC1R gene and red hair colour has been already proved. Our study focuses on the potential forensic applicability of variation within this pigmentary gene. The obtained results indicate that a major role in determination of red hair colour in our region is played by the diminished-function MC1R variants-R151C, R160W. The relatively high frequency of these variants and their significant association with red hair makes analysis of these particular positions very interesting from the perspective of phenotype prediction. D 2005 Published by Elsevier B.V
Association of polymorphic sites in the OCA2 gene with eye colour using the tree scanning method
Extracellular Matrix Collagen Alters Cell Proliferation and Cell Cycle Progression of Human Uterine Leiomyoma Smooth Muscle Cells
A global analysis of Y-chromosomal haplotype diversity for 23 STR loci
In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent