Quantitative T2 relaxation times in lower leg of Duchenne and Becker muscular dystrophy patients

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Increase in T2 relaxation times in skeletal muscle of Duchenne but not Becker muscular dystrophy patients

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

BMD patients show relative sparing of hip flexion on muscle testing and MRI

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Muscle MRS detects elevated PDE/ATP ratios prior to fatty infiltration in Becker muscular dystrophy

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

T2 RELAXATION TIMES ARE INCREASED IN SKELETAL MUSCLE OF DMD BUT NOT BMD PATIENTS

Neurological Motor Disorder

Comparison of dixon and T1-weighted MR methods to assess the degree of fat infiltration in duchenne muscular dystrophy patients

PURPOSE: To compare different lipid multipeak spectral models to the single-peak model in Dixon-based fat-water separation and to evaluate differences between visually scored magnetic resonance (MR) images and quantitatively assessed fat fractions in muscle of Duchenne muscular dystrophy patients. MATERIALS AND METHODS: T1-weighted and 3-point Dixon imaging of the upper and lower leg was performed in 13 Duchenne patients and six healthy controls. Three-, four-, and five-peak lipid spectrum models were compared to a single-peak model and to each other. T1-weighted images were visually scored by two radiologists and quantitative fat fractions were obtained from Dixon images. RESULTS: Differences between the multipeak spectral models were minimal. The three-peak model was used for subsequent comparisons. Although there was high correlation between quantitative and visual scores, visual scores were consistently higher than quantitative values of the same muscles. CONCLUSION: There are minor differences between the various lipid spectral models in terms of quantifying fat fraction in a large number of skeletal muscles in the legs of Duchenne patients and healthy controls. Quantitative 3-point Dixon MRI is more precise and reliable than visual radiological methods for evaluation of fat fractions for potential longitudinal follow-up or therapy evaluation of Duchenne patients. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Quantitative MRI and strength measurements in the assessment of muscle quality in Duchenne muscular dystrophy

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Dystrophin levels and clinical severity in Becker muscular dystrophy patients

Genetics of disease, diagnosis and treatmen

MRI detects Dp140 dystrophin isoform dependent brain changes in boys with DMD

Neuro Imaging Researc

Reduced Cerebral Gray Matter and Altered White Matter in Boys with Duchenne Muscular Dystrophy

Genetics of disease, diagnosis and treatmen