Effects of Riluzole treatment after SNC on the duration and duty factor of burst for the Sol muscles.

<p>Gray and white columns show the means for the left and right muscles in intact rats, control muscles and muscles with SNC, in saline and Riluzole treated rats. The values of SEM are not presented in graphical form because they were very small (from 0.71 to 1.67%). Abbreviations: *—<i>p</i> < 0.011.</p

The relationships between the durations of I_S-E, and I_E-S intervals and burst of Sol muscle EMG activity.

<p>(A-D) Regression lines for the relationships obtained for left and right muscles in intact rats and for control muscles and muscles with SNC in rats treated with saline after SNC at 2^nd day a.b. (2S). (E, F) Regression lines for the relationships observed for control muscles and muscles with SNC in Riluzole treated rats with 8 and 23–33 MUs in Sol and EDL muscles (RG2).</p

Changes in the cycle duration induced by SNC and treatment with Riluzole.

<p>Gray and white columns show the means of cycles established based on the Sol (A) and EDL (B) muscles for the left and right muscles as well as for control muscles and muscles with SNC in intact, saline and Riluzole treated animals. The values of SEM are not presented in graphical form because they were from 1.78 to 3.20%. Abbreviations: *—<i>p</i> < 0.005.</p

Effects of Riluzole treatment after SNC on the duty factor of burst for EDL muscles.

<p>Gray and white columns show the mean for the left and right muscles in intact rats, control muscles and muscles with SNC, in saline and Riluzole treated rats. Additional horizontal bar in the RG1 group shows the mean in rat RB5 which did not develop normal activity in the control muscle. The values of SEM are not presented in graphical form because they were from 0.57 to 3.96%. Abbreviations: *—<i>p</i> < 0.001.</p

Effects of Riluzole treatment after SNC on the burst duration of EDL muscle EMG activity and co-activation with Sol muscle.

<p>(A, B) Horizontal bars show the duration of burst of Sol and EDL muscle EMG activity presented as the sum of I_S-E and I_E-S interval durations, with the duration of muscle co-activation expressed as a percentage of cycle duration, for left and right muscles in intact rats, control muscles and muscles with SNC, in saline and Riluzole treated rats. Additional horizontal bar in the RG1 group shows the mean duration in rat RB5 which did not develop normal activity in the control muscle.</p

The phase shifts of interlimb and intralimb coordination.

<p>(A) Phase shifts for interlimb (R/SNC Sol—L/Co Sol; R/SNC EDL- L/Co EDL) coordination calculated using the cycle duration obtained for the left and control Sol and EDL muscles. (B) Phase shifts for intralimb (L/Co Sol—L/Co EDL; R/SNC Sol—R/SNC EDL) coordination calculated using the cycle durations obtained for the left and right Sol muscles, control Sol muscles and with SNC. Gray and white columns show the mean values obtained in intact, saline and Riluzole treated rats. SEM are not presented in graphical form because they ranged from 0.64 to 1.99%. Abbreviations: L/Co—left/control, R/SNC—right/muscle with SNC, Sol—soleus, EDL- extensor digitorum longus, *—<i>p <</i> 0.001.</p

Motor unit numbers in the Sol and EDL muscles in rats treated either with saline or Riluzole after SNC inflicted at 1^st and 2^nd day after birth (a.b.).

<p>Motor unit numbers in the Sol and EDL muscles in rats treated either with saline or Riluzole after SNC inflicted at 1^st and 2^nd day after birth (a.b.).</p

Effects of Riluzole treatment after SNC on the relationships for the Sol muscles.

<p>(A-J) Regression lines obtained for the left and right muscles in individual intact rats, control muscles and muscles with SNC in saline and Riluzole treated rats.</p

Explanation of time intervals used for data analysis.

<p>The vertical lines in the upper part of this figure denote examples of time intervals used to calculate phase shifts of inter- and intralimb coordination in intact rat. The vertical lines at the bottom of figure denote time intervals I_S-E and I_E-S used in the analysis of relationships between the burst duration of the right EDL muscle and the burst duration of the right Sol muscle EMG activity in intact rat. Abbreviations: L—left, R—right, Sol—soleus, EDL—extensor digitorum longus, Inter-interlimb coordination, Intra-intralimb coordination, T—burst duration of muscle EMG activity.</p