Protein transport with different small pores radii.

<p>Total albumin flow across large pores (continuous line) and small pores (dashed line). Left panel) small pores radius 45 Å. Right panel) small pores radius 55 Å.</p

Median values of the simulated fluid flows between vascular and interstitial space during HD.

<p>Line with squares: net filtration through pores; line with diamonds: lymphatic flow; dot and dash line: large pores; continuous line: small pores; dashed line: ultrasmall pores.</p

Operative conditions of the HD treatment before each session.

<p>* p-value < 0.05 when compared to the other groups.</p

Diffusive and convective protein transport.

<p>Diffusive flow (continuous line) and convective flow (dashed line) through large pores (top panel), small pores with radius 45 Å, and small pores with radius 55 Å (bottom panels). Note the different scale of the vertical axes in the upper graph.</p

Comparison of the parameters of the model for sessions 1 and 3, in medians [quartiles].

<p>The first four parameters are estimated through minimization of an error function (RMSE). V_p,0 and C_p,0 are estimated in a 10% neighborhood of the measured values of plasma volume and total protein concentration shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159748#pone.0159748.t003" target="_blank">Table 3</a>. * p < 0.05 for HD1 vs. HD2 and HD3.</p

Median values of transcapillary fluid flows under different parameters.

<p>Left panel) sensitivity of lymph flow to interstitial pressure changed from 0.4 to 1.0. Right panel) initial interstitial-to-plasma protein concentration ratio (<i>R</i>_<i>0</i>) increased from 0.4 to 0.6. Line with squares: net filtration through pores; line with diamonds: lymphatic flow; dot and dash line: large pores; continuous line: small pores; dashed line: ultrasmall pores.</p

Characteristics of the patients measured before each HD session expressed as median [quartiles].

<p>Characteristics of the patients measured before each HD session expressed as median [quartiles].</p

Median values and quartiles of several parameters for different versions of the model.

<p>Parameters for the baseline model were: r_SP = 45Å, α_SP = 0.6, R₀ = 0.4, LS = 0.4. Legend: α08) α_SP = 0.8; r55) SP radius = 55 Å; R06) initial C_i/C_p ratio = 0.6; LS1) lymphatic sensitivity = 1.0. * = p < 0.05 vs. baseline. Only HD1 data are shown.</p

Information on the samples of patients.

<p>Age and vintage values are shown as median (range). No statistical differences were found in the parameters described.</p

Effects of changing R₀.

<p>Left panel) linear correlation between different values of R₀ and calculated capillary hydraulic pressure. Median values of P_c (continuous line) and quartiles (dotted lines). Right panel) values of lymphatic flow obtained with different R₀ (dashed lines), compared to the total refilling flow (line with squares).</p