Plasma concentrations of (a) glucose, (b) insulin and (c) leptin, in intermittent air with standard diet (IA-SD), intermittent hypoxia with standard diet (IH-SD), intermittent air and high fat diet (IA-HFD) and intermittent hypoxia and high fat diet (IH-HFD) mice.

<p>Results are expressed as mean ± standard deviation and represent n = 6–8 mice, *<i>p</i> < 0.05</p

Nitric oxide (NO) production in aortas from intermittent air with standard diet (IA-SD), intermittent hypoxia with standard diet (IH-SD), intermittent air and high fat diet (IA-HFD) and intermittent hypoxia and high fat diet (IH-HFD) mice.

<p>Values are expressed in arbitrary units of amplitude per weight (mg) of dried tissue. Data are presented as mean ± standard deviation. And represent n = 5–7 mice *<i>p</i><0.05.</p

Effects of short-term intermittent hypoxia (IH) and high-fat diet (HFD) on body weight, food intake, liver mass, epididymal fat pad, lipid metabolism, and liver triglyceride content in mice.

<p>Values are expressed as mean ± standard deviation;</p><p>*<i>p</i><0.05 vs IA-SD.</p><p>^#<i>p</i><0.05 vs IA-HFD mice.</p><p>^§ p<0.05 vs IH-SD. IA intermittent air, IH intermittent hypoxia, SD standard diet, HFD high fat diet</p><p>Effects of short-term intermittent hypoxia (IH) and high-fat diet (HFD) on body weight, food intake, liver mass, epididymal fat pad, lipid metabolism, and liver triglyceride content in mice.</p

Western blotting performed in aortas from intermittent air with standard diet (IA-SD), intermittent hypoxia with standard diet (IH-SD), intermittent air and high fat diet (IA-HFD) and intermittent hypoxia and high fat diet (IH-HFD) mice using antibodies raised against (a) eNOS, (b) phospho-eNOS Ser 1177, (c) phospho-eNOS Thr 495.

<p>Immunoblots were quantified by densitometric analysis. Data are representative of 3–4 separate blots representing aorta lysates from 3–4 different mice. Densitometry values are expressed in arbitrary units (A.U.) as mean ± standard deviation. (d) The ratio of phosphorylation of eNOS at the inhibitor site (Thr 495) and activation site (Ser 1177) is expressed in arbitrary units (A.U.) as mean ± standard deviation and represent n = 3–4 mice *<i>p</i>< 0.05, **<i>p</i> <0.01.</p

Study population at baseline.

<p>Values expressed as mean (SD) or n (%). BMI = body mass index, LTOT = long-term oxygen therapy, OHS = obesity hypoventilation syndrome, ICU = intensive care unit, FEV₁ = forced expiratory volume in 1 s, FVC = forced vital capacity, IPAP = inspiratory partial airway pressure, EPAP = expiratory partial airway pressure, Min RR = minimal respiratory rate</p><p>Study population at baseline.</p

Comparison of NIV efficacy at 6 months in patients aged < 75 years or ≥ 75 years.

<p>Δ: variation between baseline and 6 months</p><p>*p value < 0.05</p><p>^†percentage of patients with initial Epworth scale score over 10</p><p>^§ percentage of patients with initial Pittsburgh sleep quality index over 7</p><p>^‡p value for comparison of Δ between ≥ 75 and < 75</p><p>ESS: Epworth scale score, PSQI: Pittsburgh sleep quality index</p><p>Comparison of NIV efficacy at 6 months in patients aged < 75 years or ≥ 75 years.</p

Predictive factors for adherence in patients aged ≥ 75.

<p>OHS: obesity hypoventilation syndrome, MMSE: mini mental state examination</p><p>Predictive factors for adherence in patients aged ≥ 75.</p

Comparison of the impact of NIV on HRQL evaluated by SF-36 in patients aged < 75 years or ≥ 75 years.

<p>Values expressed as mean (SD).</p><p>Δ: variation between baseline and 6 months</p><p>*p value < 0.05</p><p>^‡p value for comparison of Δ between ≥ 75 and < 75</p><p>PCS: physical component summary, MCS: mental component summary</p><p>Comparison of the impact of NIV on HRQL evaluated by SF-36 in patients aged < 75 years or ≥ 75 years.</p