Using planar laser-induced fluorescence to study the phase transformations of two-component liquid and suspension droplets

Using the planar laser-induced fluorescence (PLIF), we performed experiments to determine evaporation dynamics of homogeneous and heterogeneous droplets of liquids, conditions of their boiling, and explosive breakup. For the 1–2 mm water droplets, the distribution of highly non-homogeneous and non-steady temperature field was detected by highspeed cross-correlation video recording and the Tema Automotive software.We identified highly nonlinear dependences of evaporation rate on heating temperature and time as well as water droplet size. For the two-component liquids and water-based suspensions of graphite, we revealed unsteady temperature fields and established mechanisms and regimes of the explosive breakup of the heterogeneous droplets when heated. The regimes differ in the number and dimensions of the emerging gas–liquid fragments as well as the durations of the main stages. The three regimes of warming-up and evaporation of the heterogeneous droplets have been obtained. The explosive breakup of droplets enables provision for the secondary atomization of the liquid with the emergence of an aerosol cloud. The surface area of the liquid increases several-fold. The temperature variations at the water/solid or water/flammable component interfaces were determined corresponding to each boiling and breakup regime. Using the PLIF, we studied reasons and mechanism of the explosive breakup of water droplets with single large carbonaceous inclusions when heated

Математическая модель прогнозирования продаж товаров с высокой эластичностью спроса

В работе автор проводит обзор методов прогнозирования, приводит особенности прогнозирования, связанные с прогнозированием в сети продуктового ретейла. На основе предоставленных от компании данных разрабатывает математическую модель товаров, имеющих высокую ценовую эластичность спроса, и внедряет в процесс управления товарными запасами компании.In the work, the author reviews the forecasting methods, gives the forecasting features associated with forecasting in the network of food retail. Based on the data provided by the company, he develops a mathematical model of goods with high price elasticity of demand and implements the company’s inventory management process

Оптимизация многостадийного гидравлического разрыва пласта на горизонтальных скважинах нефтяного месторождения "Х" (Томская область)

В работе представлен анализ опыта применения горизонтальных скважин с МГРП на месторождении "Х" (Томская область). В ходе работы предложены методики, на основании которых были подобраны 65 скважин-кандидатов, на которых можно эффективно провести операцию ГРП. Помимо этого, на основе анализа проведения ГРП на месторождениях аналогов, предложены мероприятия по повышению эффективности операции.The paper presents an analysis of the experience of using horizontal wells with multistage fracturing at the "X" field (Tomsk region). In the course of the work, methods were proposed, on the basis of which 65 candidate wells were selected, on which it is possible to effectively carry out hydraulic fracturing. In addition, based on the analysis of hydraulic fracturing in analogous fields, measures were proposed to improve the efficiency of the operation

Совершенствование технологического процесса изготовления детали «Корпус»

Совершенствование технологического процесса изготовления детали «Корпус». Технологический раздел, Конструкторский раздел, Технико-экономическое обоснование ,Социальная ответственность.Perfection of technological process of manufacturing parts "Housing". Technological section, design section, Feasibility Study, Social Responsibility

Comment on "Periodic Phase Synchronization in Coupled Chaotic Oscillators"

2 pages.-- PACS numbers: 05.45.Xt, 05.45.Pq.-- Final full-text version of the paper available at: http://dx.doi.org/10.1103/PhysRevE.73.038201.Kye et al. [Phys. Rev. E 68, 025201(R) (2003)] have recently claimed that, before the onset of Chaotic Phase Synchronization in coupled phase coherent oscillators, there exists a temporally coherent state called Periodic Phase Synchronization (PPS). Here we give evidence that some of their numerical calculations are flawed, while we provide theoretical arguments that indicate that PPS is not to be expected generically in this type of systems.This work was supported by MEC (Spain) and FEDER under Grant Nos. BFM2001-0341-C02-02, FIS2004-00953 (CONOCE2), and FIS2004-05073-C04-03.http://dx.doi.org/10.1103/PhysRevE.73.03820

Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma

Targeted inhibition of the c-Jun N-terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)-related tumorigenesis. However, the cell-type-specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate the relevance of JNK1 and JNK2 function in hepatocytes in two different models of experimental carcinogenesis, the dethylnitrosamine (DEN) model and in nuclear factor kappa B essential modulator (NEMO)(hepatocyte-specific knockout (Deltahepa)) mice, focusing on liver damage, cell death, compensatory proliferation, fibrogenesis, and tumor development. Moreover, regulation of essential genes was assessed by reverse transcription polymerase chain reaction, immunoblottings, and immunostainings. Additionally, specific Jnk2 inhibition in hepatocytes of NEMO(Deltahepa)/JNK1(Deltahepa) mice was performed using small interfering (si) RNA (siJnk2) nanodelivery. Finally, active signaling pathways were blocked using specific inhibitors. Compound deletion of Jnk1 and Jnk2 in hepatocytes diminished hepatocellular carcinoma (HCC) in both the DEN model and in NEMO(Deltahepa) mice but in contrast caused massive proliferation of the biliary ducts. Indeed, Jnk1/2 deficiency in hepatocytes of NEMO(Deltahepa) (NEMO(Deltahepa)/JNK(Deltahepa)) animals caused elevated fibrosis, increased apoptosis, increased compensatory proliferation, and elevated inflammatory cytokines expression but reduced HCC. Furthermore, siJnk2 treatment in NEMO(Deltahepa)/JNK1(Deltahepa) mice recapitulated the phenotype of NEMO(Deltahepa)/JNK(Deltahepa) mice. Next, we sought to investigate the impact of molecular pathways in response to compound JNK deficiency in NEMO(Deltahepa) mice. We found that NEMO(Deltahepa)/JNK(Deltahepa) livers exhibited overexpression of the interleukin-6/signal transducer and activator of transcription 3 pathway in addition to epidermal growth factor receptor (EGFR)-rapidly accelerated fibrosarcoma (Raf)-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) cascade. The functional relevance was tested by administering lapatinib, which is a dual tyrosine kinase inhibitor of erythroblastic oncogene B-2 (ErbB2) and EGFR signaling, to NEMO(Deltahepa)/JNK(Deltahepa) mice. Lapatinib effectively inhibited cystogenesis, improved transaminases, and effectively blocked EGFR-Raf-MEK-ERK signaling. Conclusion: We define a novel function of JNK1/2 in cholangiocyte hyperproliferation. This opens new therapeutic avenues devised to inhibit pathways of cholangiocarcinogenesis