18 research outputs found
Genome modeling system: A knowledge management platform for genomics
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides detailed tracking of samples and data coupled with reliable and repeatable analysis pipelines. The GMS also serves as a platform for bioinformatics development, allowing a large team to collaborate on data analysis, or an individual researcher to leverage the work of others effectively within its data management system. Rather than separating ad-hoc analysis from rigorous, reproducible pipelines, the GMS promotes systematic integration between the two. As a demonstration of the GMS, we performed an integrated analysis of whole genome, exome and transcriptome sequencing data from a breast cancer cell line (HCC1395) and matched lymphoblastoid line (HCC1395BL). These data are available for users to test the software, complete tutorials and develop novel GMS pipeline configurations. The GMS is available at https://github.com/genome/gms
Toward a Fast, Easy, and Versatile Immobilization of Biomolecules into Carbon Nanotube/Polysulfone-Based Biosensors for the Detection of hCG Hormone
Motor-Based Autonomous Microsensor for Motion and Counting Immunoassay of Cancer Biomarker
Chemical Stability of ZnO Nanostructures in Simulated Physiological Environments and Its Application in Determining Polar Directions
Radial deformation of single-walled carbon nanotubes on quartz substrates and the resultant anomalous diameter-dependent reaction selectivity
Covalent Immobilization of Proteins on Carbon Nanotubes Using the Cross-Linker 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide—a Critical Assessment
Decoration of tricarboxylic and monocarboxylic aryl diazonium functionalized multi-wall carbon nanotubes with iron nanoparticles
Carbon nanotubes: Synthesis, structure, functionalization, and characterization
Carbon nanotubes have generated great expectations in the scientific arena, mainly due to their spectacular properties, which include a high aspect ratio, high strain resistance, and high strength, along with high conductivities. Nowadays, carbon nanotubes are produced by a variety of methods, each of them with advantages and disadvantages. Once produced, carbon nanotubes can be chemically modified, using a wide range of chemical reactions. Functionalization makes these long wires much easier to manipulate and dispersible in several solvents. In addition, the properties of carbon nanotubes can be combined with those of organic appendages. Finally, carbon nanotubes need to be carefully characterized, either as pristine or modified materials