Evaluation of health applications to support the asthma treatment process, available in Poland

Introduction: Asthma is one of the most frequently diagnosed chronic diseases in the world. All elements of treatment should primarily focus on controlling the disease and activating the patient and his participation in the treatment process. With the help of e-health and telemedicine in the form of applications for smartphones, thus independent coping with chronic diseases. The aim of the study was a quantitative and qualitative assessment of applications supporting such a business process in Polish. Material and methods: The study was based on a review and checking of applications using criteria using various types of mobile devices, algorithms by various operating systems. The search for those qualified for the analysis was carried out from October 14 to November 8, 2022 on the basis of the words: asthma, application, dairy products. Results: 4 asthma apps were analyzed. The highest quality documents of the Mytherapy application - 5.5 points/12 points - do not verify this threshold of good quality applications - a minimum of 75% of use to obtain points. Conclusions have been checked: These conclusions suggest a direction, regardless of the attempt to create an application that addresses the topic holistically, as well as research in this area.

Multiparameter flow cytometry for assessment of minimal residual disease in patients with myelodysplastic syndromes treated with allogeneic stem cell transplantation

BackgroundMyelodysplastic syndromes (MDSs) are a heterogeneous group of clonal myeloid neoplasms. Allogeneic stem cell transplantation (allo-SCT) remains the curative method for MDS treatment. Little is known about the monitoring of minimal residual disease (MRD) in patients with MDS after allo-SCT. AimWe aimed to evaluate the significance of leukemia-associated immunophenotypes (LAIPs) identified in acute myeloid leukemia (AML) for MRD monitoring in patients with MDS after allo-SCT. Material and methodsSeven males and 4 females with a median age of 55 years were included. The diagnosis of MDS was established according to 2016 World Health Organization (WHO) criteria. The significance of eight LAIPs in bone marrow samples using multiparameter flow cytometry (MFC) was evaluated for MRD. ResultsEight patients were positive for several LAIPs before allo-SCT. The identified LAIPs included the presence of aberrant lymphoid antigens on myeloblasts and lack of CD33 expression on myeloblasts. All studied MDS patients were negative for LAIPs at Day +30 after the procedure. This was followed by full-donor chimerism in all cases. The Ogata score after allo-SCT decreased in all patients in whom it was indicative for MDS before allo-SCT. ConclusionsMFC could be useful in monitoring MRD in MDS patients after allo-SCT. Further studies in this field are needed