Spatial mean interstitial fluid pressure and transvacular flux per tumour volume as a function of tumour size.

<p>Spatial mean interstitial fluid pressure and transvacular flux per tumour volume as a function of tumour size.</p

Estimation of blood vessel surface area to tissue volume ratio of tumours with various tumour sizes (experimental data extracted from [6]).

<p>For the best fitted curve using equation <i>y</i> = <i>ax</i>^<i>b</i> (a = 54.68, b = -0.2021).</p

Spatial mean doxorubicin extracellular concentration as a function of time under 2-hour continuous infusion, dose = 50 mg/m².

<p>(a) Free and (b) bound doxorubicin in tumour, (c) free and (d) bound doxorubicin in normal tissue.</p

Interstitial fluid pressure distribution in tumour and normal tissue.

<p>Interstitial fluid pressure distribution in tumour and normal tissue.</p

Reconstructed 3-D models showing tumours of varying sizes and their surrounding tissues.

<p>Reconstructed 3-D models showing tumours of varying sizes and their surrounding tissues.</p

MR image of a tumour (in orange) and its surrounding tissue (in pale blue).

<p>MR image of a tumour (in orange) and its surrounding tissue (in pale blue).</p

Schematic of drug transport model with continuous infusion of doxorubicin.

<p>Schematic of drug transport model with continuous infusion of doxorubicin.</p

Free and bound doxorubicin concentrations in blood after administration as a function of time.

<p>(infusion duration = 2 hours, total dose = 50 mg/m²).</p

Transvascular exchange of doxorubicin by convection as a function of time.

<p>(a) free and (b) bound doxorubicin exchange (2-hour infusion, total dose = 50 mg/m²).</p

Survival cell fraction of tumour as a function of time in five tumours with different sizes.

<p>(2-hour infusion, total dose = 50 mg/m²).</p