w_{\infty} Algebras, Conformal Mechanics, and Black Holes

We discuss BPS solitons in gauged ${\cal N}=2$, D=4 supergravity. The solitons represent extremal black holes interpolating between different vacua of anti-de Sitter spaces. The isometry superalgebras are determined and the motion of a superparticle in the extremal black hole background is studied and confronted with superconformal mechanics. We show that the Virasoro symmetry of conformal mechanics, which describes the dynamics of the superparticle near the horizon of the extremal black hole under consideration, extends to a symmetry under the $w_{\infty}$ algebra of area-preserving diffeomorphisms. We find that a Virasoro subalgebra of $w_{\infty}$ can be associated to the Virasoro algebra of the asymptotic symmetries of $AdS_2$. In this way spacetime diffeomorphisms of $AdS_2$ translate into diffeomorphisms in phase space: our system offers an explicit realization of the $AdS_2/CFT_1$ correspondence. Using the dimensionally reduced action, the central charge is computed. Finally, we also present generalizations of superconformal mechanics which are invariant under ${\cal N} =1$ and ${\cal N} =2$ superextensions of $w_{\infty}$.Comment: Latex, 23 pages, minor errors corrected, references added; final version to appear in Class. Quant. Gra

Fermions and noncommutative emergent gravity II: Curved branes in extra dimensions

We study fermions coupled to Yang-Mills matrix models from the point of view of emergent gravity. The matrix model Dirac operator provides an appropriate coupling for fermions to the effective gravitational metric for general branes with nontrivial embedding, albeit with a non-standard spin connection. This generalizes previous results for 4-dimensional matrix models. Integrating out the fermions in a nontrivial geometrical background induces indeed the Einstein-Hilbert action of the effective metric, as well as additional terms which couple the Poisson tensor to the Riemann tensor, and a dilaton-like term.Comment: 34 pages; minor change

Exact results in planar N=1 superconformal Yang-Mills theory

In the \beta-deformed N=4 supersymmetric SU(N) Yang-Mills theory we study the class of operators O_J = Tr(\Phi_i^J \Phi_k), i\neq k and compute their exact anomalous dimensions for N,J\to\infty. This leads to a prediction for the masses of the corresponding states in the dual string theory sector. We test the exact formula perturbatively up to two loops. The consistency of the perturbative calculation with the exact result indicates that in the planar limit the one--loop condition g^2=h\bar{h} for superconformal invariance is indeed sufficient to insure the {\em exact} superconformal invariance of the theory. We present a direct proof of this point in perturbation theory. The O_J sector of this theory shares many similarities with the BMN sector of the N=4 theory in the large R--charge limit.Comment: LaTex, 14 pages, 3 figures; v2: minor corrections and one reference adde

The Asymptotic Dynamics of two-dimensional (anti-)de Sitter Gravity

We show that the asymptotic dynamics of two-dimensional de Sitter or anti-de Sitter Jackiw-Teitelboim (JT) gravity is described by a generalized two-particle Calogero-Sutherland model. This correspondence is established by formulating the JT model of (A)dS gravity in two dimensions as a topological gauge theory, which reduces to a nonlinear 0+1-dimensional sigma model on the boundary of (A)dS space. The appearance of cyclic coordinates allows then a further reduction to the Calogero-Sutherland quantum mechanical model.Comment: 16 pages, LaTeX, no figures, uses JHEP.cls. v2: Some references and comments added. v3: Minor errors correcte

BPS equations in N=2, D=5 supergravity with hypermultiplets

With the general aim to classify BPS solutions in N=2, D=5 supergravities interacting with an arbitrary number of vector, tensor and hypermultiplets, here we begin considering the most general electrostatic, spherical-symmetric BPS solutions in the presence of hypermultiplet couplings. We discuss the properties of the BPS equations and the restrictions imposed by their integrability conditions. We exhibit explicit solutions for the case of static BPS black-holes coupled to one (the so called universal) hypermultiplet.Comment: 20 pages, v3 some corrections performed; we thank A.Van Proeyen for the pointing ou

A Recoding Method to Improve the Humoral Immune Response to an HIV DNA Vaccine

This manuscript describes a novel strategy to improve HIV DNA vaccine design. Employing a new information theory based bioinformatic algorithm, we identify a set of nucleotide motifs which are common in the coding region of HIV, but are under-represented in genes that are highly expressed in the human genome. We hypothesize that these motifs contribute to the poor protein expression of gag, pol, and env genes from the c-DNAs of HIV clinical isolates. Using this approach and beginning with a codon optimized consensus gag gene, we recode the nucleotide sequence so as to remove these motifs without modifying the amino acid sequence. Transfecting the recoded DNA sequence into a human kidney cell line results in doubling the gag protein expression level compared to the codon optimized version. We then turn both sequences into DNA vaccines and compare induced antibody response in a murine model. Our sequence, which has the motifs removed, induces a five-fold increase in gag antibody response compared to the codon optimized vaccine

On the perturbative chiral ring for marginally deformed N=4 SYM theories

For \cal{N}=1 SU(N) SYM theories obtained as marginal deformations of the \cal{N}=4 parent theory we study perturbatively some sectors of the chiral ring in the weak coupling regime and for finite N. By exploiting the relation between the definition of chiral ring and the effective superpotential we develop a procedure which allows us to easily determine protected chiral operators up to n loops once the superpotential has been computed up to (n-1) order. In particular, for the Lunin-Maldacena beta-deformed theory we determine the quantum structure of a large class of operators up to three loops. We extend our procedure to more general Leigh-Strassler deformations whose chiral ring is not fully understood yet and determine the weight-two and weight-three sectors up to two loops. We use our results to infer general properties of the chiral ring.Comment: LaTex, 40 pages, 4 figures, uses JHEP3; v2: minor correction