645 research outputs found
Screening correlators with chiral Fermions
We study screening correlators of quark-antiquark composites at T=2T_c, where
T_c is the QCD phase transition temperature, using overlap quarks in the
quenched approximation of lattice QCD. As the lattice spacing is changed from
1/4T to a=1/6T and 1/8T, we find that screening correlators change little, in
contrast with the situation for other types of lattice fermions. All
correlators are close to the ideal gas prediction at small separations. The
long distance falloff is clearly exponential, showing that a parametrization by
a single screening length is possible at distances z > 1/T. The correlator
corresponding to the thermal vector is close to the ideal gas value at all
distances, whereas that for the thermal scalar deviates at large distances.
This is examined through the screening lengths and momentum space correlators.
There is strong evidence that the screening transfer matrix does not have
reflection positivity.Comment: 10 pages, 9 fig
Mesonic screening masses at high temperature and finite density
We compute the first perturbative correction to the static correlation
lengths of light quark bilinears in hot QCD with finite quark chemical
potentials. The correction is small and positive, with mu-dependence depending
on the relative sign of chemical potentials and the number of dynamical
flavors. The computation is carried out using a three-dimensional effective
theory for the lowest fermionic Matsubara mode. We also compute the full
correlator in free theory and find a rather complicated general mu-dependence
at shorter distances. Finally, rough comparisons with lattice simulations are
discussed.Comment: 24 pages, 5 figures, JHEP style. Minor corrections and
clarifications, version to appear in JHE
The influence of laser relative intensity noise in the Laser Interferometer Space Antenna
LISA is an upcoming ESA mission that will detect gravitational waves in spaceby interferometrically measuring the separation between free-falling testmasses at picometer precision. To reach the desired performance, LISA willemploy the noise reduction technique time-delay interferometry (TDI), in whichmultiple raw interferometric readouts are time shifted and combined into thefinal scientific observables. Evaluating the performance in terms of these TDIvariables requires careful tracking of how different noise sources propagatethrough TDI, as noise correlations might affect the performance in unexpectedways. One example of such potentially correlated noise is the relativeintensity noise (RIN) of the six lasers aboard the three LISA satellites, whichwill couple into the interferometric phase measurements. In this article, wecalculate the expected RIN levels based on the current mission architecture andthe envisaged mitigation strategies. We find that strict requirements on thetechnical design reduce the effect from approximately 8.7 pm/rtHz perinter-spacecraft interferometer to that of a much lower sub-1 pm/rtHz noise,with typical characteristics of an uncorrelated readout noise after TDI. Ourinvestigations underline the importance of sufficient balanced detection of theinterferometric measurements.<br
Pain Reduction in Adults with Limb Spasticity Following Treatment with IncobotulinumtoxinA: a Pooled Analysis
Some studies have shown that incobotulinumtoxinA reduces spasticity-associated pain, but further evidence is needed. This exploratory analysis pooled pain-relief data from six Phase 2 or 3 studies of incobotulinumtoxinA (four placebo-controlled studies) for treating upper limb spasticity in adults. Spasticity-associated pain was assessed at baseline and 4 weeks post incobotulinumtoxinA injection using the disability assessment scale (DAS) for pain. Only data for patients with pain at baseline were analysed. Overall, 544 (incobotulinumtoxinA, N = 415; placebo, N = 129) of 937 patients (58.1%) experienced pain at baseline. At Week 4, a significantly greater proportion of incobotulinumtoxinA- (52.1%) than placebo-treated patients (28.7%; Chi-square p < 0.0001) showed a response (≥1-point improvement in DAS pain score). In logistic regression analysis, incobotulinumtoxinA-treated patients were 2.6 times more likely to achieve this endpoint than placebo-treated patients. A significant difference between incobotulinumtoxinA and placebo was observed regardless of baseline pain severity. Additionally, 27.1% of incobotulinumtoxinA- versus 12.4% of placebo-treated patients reported complete pain relief at Week 4 (p = 0.0006). Pain relief increased with multiple injection cycles. To achieve patient-centred care, pain relief may be considered a treatment goal in adults with spasticity-associated pain regardless of pain severity. This study contributes to understanding the benefits of incobotulinumtoxinA in treating limb spasticity-associated pain.info:eu-repo/semantics/publishedVersio
Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.
Three mitochondria-encoded subunits form the catalytic core of cytochrome c oxidase, the terminal enzyme of the respiratory chain. COX1 and COX2 contain heme and copper redox centers, which are integrated during assembly of the enzyme. Defects in this process lead to an enzyme deficiency and manifest as mitochondrial disorders in humans. Here we demonstrate that COA6 is specifically required for COX2 biogenesis. Absence of COA6 leads to fast turnover of newly synthesized COX2 and a concomitant reduction in cytochrome c oxidase levels. COA6 interacts transiently with the copper-containing catalytic domain of newly synthesized COX2. Interestingly, similar to the copper metallochaperone SCO2, loss of COA6 causes cardiomyopathy in humans. We show that COA6 and SCO2 interact and that corresponding pathogenic mutations in each protein affect complex formation. Our analyses define COA6 as a constituent of the mitochondrial copper relay system, linking defects in COX2 metallation to cardiac cytochrome c oxidase deficiency
Development Toward a Ground-Based Interferometric Phased Array for Radio Detection of High Energy Neutrinos
The in-ice radio interferometric phased array technique for detection of high
energy neutrinos looks for Askaryan emission from neutrinos interacting in
large volumes of glacial ice, and is being developed as a way to achieve a low
energy threshold and a large effective volume at high energies. The technique
is based on coherently summing the impulsive Askaryan signal from multiple
antennas, which increases the signal-to-noise ratio for weak signals. We report
here on measurements and a simulation of thermal noise correlations between
nearby antennas, beamforming of impulsive signals, and a measurement of the
expected improvement in trigger efficiency through the phased array technique.
We also discuss the noise environment observed with an analog phased array at
Summit Station, Greenland, a possible site for an interferometric phased array
for radio detection of high energy neutrinos.Comment: 13 Pages, 14 Figure
The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitor.
Topoisomerase I inhibitors are new compounds of interest for cancer chemotherapy. We performed a study with GI147211, a new semisynthetic camptothecin analogue, to determine the absolute bioavailability of the drug given orally. Patients with a histologically confirmed diagnosis of a solid tumour refractory to standard forms of therapy were eligible for the study. GI147211 was given orally on day 1 and as a 30-min infusion daily on days 2-5. The treatment course was repeated every 3 weeks. In subsequent patient cohorts, the dose of the oral formulation was escalated from 1.5 mg m(-2) to 6.0 mg m(-2); the dose for i.v. administration was fixed at 1.2 mg m(-2). Plasma pharmacokinetics was performed on day 1 and 2 of the first course and on day 1 of the second course using a validated high-performance liquid chromatographic assay. Nineteen patients were entered into the study; one patient was not evaluable because the treatment course was stopped prematurely. Eighteen patients received a total of 47 treatment courses. The absolute bioavailability of GI147211 averaged 1.3 +/- 5.2%. Drug appeared quickly in plasma with a median Tmax at 0.5 h. Fasting or fed state had no significant influence on the bioavailability of GI147211. The terminal half-life after administration of oral GI147211 was 6.85 +/- 3.13 h, similar to the half-life after intravenous administration. The major toxicities were neutropenia and thrombocytopenia. Nadirs for neutropenia and thrombocytopenia occurred on day 8 and day 15 respectively. Other toxicities predominantly consisted of mild and infrequent nausea and vomiting, and fatigue. The oral administration of the drug is well tolerated. Oral administration of topoisomerase I inhibitor GI147211 results in a low bioavailability with relatively wide interpatient variation. The intravenous route of administration is advised for further development of this promising topoisomerase I inhibitor
Efficient Dynamic Importance Sampling of Rare Events in One Dimension
Exploiting stochastic path integral theory, we obtain \emph{by simulation}
substantial gains in efficiency for the computation of reaction rates in
one-dimensional, bistable, overdamped stochastic systems. Using a well-defined
measure of efficiency, we compare implementations of ``Dynamic Importance
Sampling'' (DIMS) methods to unbiased simulation. The best DIMS algorithms are
shown to increase efficiency by factors of approximately 20 for a
barrier height and 300 for , compared to unbiased simulation. The
gains result from close emulation of natural (unbiased), instanton-like
crossing events with artificially decreased waiting times between events that
are corrected for in rate calculations. The artificial crossing events are
generated using the closed-form solution to the most probable crossing event
described by the Onsager-Machlup action. While the best biasing methods require
the second derivative of the potential (resulting from the ``Jacobian'' term in
the action, which is discussed at length), algorithms employing solely the
first derivative do nearly as well. We discuss the importance of
one-dimensional models to larger systems, and suggest extensions to
higher-dimensional systems.Comment: version to be published in Phys. Rev.
Simulation study of the inhomogeneous Olami-Feder-Christensen model of earthquakes
Statistical properties of the inhomogeneous version of the
Olami-Feder-Christensen (OFC) model of earthquakes is investigated by numerical
simulations. The spatial inhomogeneity is assumed to be dynamical. Critical
features found in the original homogeneous OFC model, e.g., the
Gutenberg-Richter law and the Omori law are often weakened or suppressed in the
presence of inhomogeneity, whereas the characteristic features found in the
original homogeneous OFC model, e.g., the near-periodic recurrence of large
events and the asperity-like phenomena persist.Comment: Shortened from the first version. To appear in European Physical
Journal
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