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Use of quality control methods in monitoring the purchasing behaviour of consumer panels
\u3cem\u3eDe Novo\u3c/em\u3e [PSI\u3csup\u3e+\u3c/sup\u3e] Prion Formation Involves Multiple Pathways to Form Infectious Oligomers
Prion and other neurodegenerative diseases are associated with misfolded protein assemblies called amyloid. Research has begun to uncover common mechanisms underlying transmission of amyloids, yet how amyloids form in vivo is still unclear. Here, we take advantage of the yeast prion, [PSI +], to uncover the early steps of amyloid formation in vivo. [PSI +] is the prion form of the Sup35 protein. While [PSI +] formation is quite rare, the prion can be greatly induced by overexpression of the prion domain of the Sup35 protein. This de novo induction of [PSI +] shows the appearance of fluorescent cytoplasmic rings when the prion domain is fused with GFP. Our current work shows that de novoinduction is more complex than previously thought. Using 4D live cell imaging, we observed that fluorescent structures are formed by four different pathways to yield [PSI +] cells. Biochemical analysis of de novo induced cultures indicates that newly formed SDS resistant oligomers change in size over time and lysates made from de novo induced cultures are able to convert [psi −] cells to [PSI +] cells. Taken together, our findings suggest that newly formed prion oligomers are infectious
Lateral grating DFB AlGaInN laser diodes for optical communications and atomic clocks
AlGaInN laser diode technology is of considerable interest for telecom applications and next generation atomic optical clocks based on Sr (by using 422nm & 461nm) and Rb at 420.2nm.Very narrow linewidths (<1MHz) are required for such applications. We report lateral gratings on AlGaInN ridge waveguide laser diodes to achieve a single wavelength device with a good side mode suppression ratio (SMSR) that is suitable for atomic clock and telecom applications
Degenerate Sectors of the Ashtekar Gravity
This work completes the task of solving locally the Einstein-Ashtekar
equations for degenerate data. The two remaining degenerate sectors of the
classical 3+1 dimensional theory are considered. First, with all densitized
triad vectors linearly dependent and second, with only two independent ones. It
is shown how to solve the Einstein-Ashtekar equations completely by suitable
gauge fixing and choice of coordinates. Remarkably, the Hamiltonian weakly
Poisson commutes with the conditions defining the sectors. The summary of
degenerate solutions is given in the Appendix.Comment: 19 pages, late
Near-infrared line identification in type Ia supernovae during the transitional phase
We present near-infrared synthetic spectra of a delayed-detonation
hydrodynamical model and compare them to observed spectra of four normal type
Ia supernovae ranging from day +56.5 to day +85. This is the epoch during which
supernovae are believed to be undergoing the transition from the photospheric
phase, where spectra are characterized by line scattering above an optically
thick photosphere, to the nebular phase, where spectra consist of optically
thin emission from forbidden lines. We find that most spectral features in the
near-infrared can be accounted for by permitted lines of Fe II and Co II. In
addition, we find that [Ni II] fits the emission feature near 1.98 {\mu}m,
suggesting that a substantial mass of 58Ni exists near the center of the ejecta
in these objects, arising from nuclear burning at high density. A tentative
identification of Mn II at 1.15 {\mu}m may support this conclusion as well.Comment: accepted to Ap
Influence of low-level Pr substitution on the superconducting properties of YBa2Cu3O7-delta single crystals
We report on measurements on Y1-xPrxBa2Cu3O7-delta single crystals, with x
varying from 0 to 2.4%. The upper and the lower critical fields, Hc2 and Hc1,
the Ginzburg-Landau parameter and the critical current density, Jc(B), were
determined from magnetization measurements and the effective media approach
scaling method. We present the influence of Pr substitution on the pinning
force density as well as on the trapped field profiles analyzed by Hall probe
scanning.Comment: 4 pages, 5 figures, accepted for publication in J. Phys. Conf. Se
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