Tamoxifen and related compounds decrease membrane fluidity in liposomes Mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?

AbstractTamoxifen and related compounds decrease membrane fluidity in ox-brain phospholipid liposomes: their order of effectiveness is, 4-hydroxytamoxifen > 17β-oestradiol > tamoxifen >cis-tamoxifen >N-desmethyltamoxifen > cholesterol. A good positive correlation was demonstrated between the decrease in membrane fluidity by these compounds and their antioxidant ability as inhibitors of liposomal and microsomal lipid peroxidation (correlation coefficient, r = 0.99, P < 0.001, in both cases). The ability of tamoxifen to decrease membrane fluidity is suggested to be the mechanism of its antioxidant action and is discussed in relation to its anticancer and cardioprotective actions

Completion of markets by variation processes

Paper presented at Strathmore International Math Research Conference on July 23 - 27, 2012Paper presented at Strathmore International Mathematics Research Conference on July 23 - 27, 201

Tamoxifen and related compounds decrease membrane fluidity in liposomes Mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?

AbstractTamoxifen and related compounds decrease membrane fluidity in ox-brain phospholipid liposomes: their order of effectiveness is, 4-hydroxytamoxifen > 17β-oestradiol > tamoxifen >cis-tamoxifen >N-desmethyltamoxifen > cholesterol. A good positive correlation was demonstrated between the decrease in membrane fluidity by these compounds and their antioxidant ability as inhibitors of liposomal and microsomal lipid peroxidation (correlation coefficient, r = 0.99, P < 0.001, in both cases). The ability of tamoxifen to decrease membrane fluidity is suggested to be the mechanism of its antioxidant action and is discussed in relation to its anticancer and cardioprotective actions

I see you as recognizing me; therefore, I trust you: Operationalizing epistemic trust in psychotherapy

Epistemic trust (ET) is one’s ability to trust others and relies on the information they convey as being relevant and generalizable. This concept has received considerable theoretical and clinical attention, suggesting it is a promising factor in effective psychotherapy, possibly consisting of three elements: sharing, we-mode, and learning. However, for it to be used in clinical practice and research, it is imperative to (a) enhance our clinical understanding of how ET may manifest in the context of treatment and (b) understand how the process of change may occur in the course of treatment. The present study aims to identify patients’ trait-like ET characteristics upon initiating treatment and explore the possible state-like changes in ET characteristics throughout treatment. Taking a discovery-oriented approach, we examined how therapists can identify a patient’s level of ET at the beginning of treatment. We also examined how, within a treatment for individuals with poor pretreatment ET, the therapist and patient work interactively to bring about a positive change in ET. Identifying the process in which the therapist implements techniques in response to the patient’s reactions may enable the active mechanism to be isolated and promote the first formulation of the way changes in ET occur in sequence. (PsycInfo Database Record (c) 2023 APA, all rights reserved

Australia's coastal waters are rich in Indigenous cultural heritage, but it remains hidden and under threat

[Extract] In two new studies published in Australian Archaeology, we outline approaches to help us better understand and manage Indigenous underwater cultural heritage. Through a two-pronged approach at both the local and regional level, we review big data to predict the location of sites. We also put boots on the ground and divers in the water to find and record them

Feedback cooling of a single trapped ion

Based on a real-time measurement of the motion of a single ion in a Paul trap, we demonstrate its electro-mechanical cooling below the Doppler limit by homodyne feedback control (cold damping). The feedback cooling results are well described by a model based on a quantum mechanical Master Equation.Comment: 4 pages, 3 figure

Symbiotic modeling: Linguistic Anthropology and the promise of chiasmus

Reflexive observations and observations of reflexivity: such agendas are by now standard practice in anthropology. Dynamic feedback loops between self and other, cause and effect, represented and representamen may no longer seem surprising; but, in spite of our enhanced awareness, little deliberate attention is devoted to modeling or grounding such phenomena. Attending to both linguistic and extra-linguistic modalities of chiasmus (the X figure), a group of anthropologists has recently embraced this challenge. Applied to contemporary problems in linguistic anthropology, chiasmus functions to highlight and enhance relationships of interdependence or symbiosis between contraries, including anthropology’s four fields, the nature of human being and facets of being human

Cyclic networks of quantum gates

In this article initial steps in an analysis of cyclic networks of quantum logic gates is given. Cyclic networks are those in which the qubit lines are loops. Here we have studied one and two qubit systems plus two qubit cyclic systems connected to another qubit on an acyclic line. The analysis includes the group classification of networks and studies of the dynamics of the qubits in the cyclic network and of the perturbation effects of an acyclic qubit acting on a cyclic network. This is followed by a discussion of quantum algorithms and quantum information processing with cyclic networks of quantum gates, and a novel implementation of a cyclic network quantum memory. Quantum sensors via cyclic networks are also discussed.Comment: 14 pages including 11 figures, References adde