Reducing the linewidth of an atom laser by feedback

A continuous atom laser will almost certainly have a linewidth dominated by the effect of the atomic interaction energy, which turns fluctuations in the condensate atom number into fluctuations in the condensate frequency. These correlated fluctuations mean that information about the atom number could be used to reduce the frequency fluctuations, by controlling a spatially uniform potential. We show that feedback based on a physically reasonable quantum non-demolition measurement of the atom number of the condensate in situ can reduce the linewidth enormously.Comment: 5 pages, 1 figur

Effects of twin-beam squashed light on a three-level atom

An electro-optical feedback loop can make in-loop light (squashed light) which produces a photocurrent with noise below the standard quantum limit (such as squeezed light). We investigate the effect of squashed light interacting with a three-level atom in the cascade configuration and compare it to the effects produced by squeezed light and classical noise. It turns out that one master equation can be formulated for all three types of light and that this unified formalism can also be applied to the evolution of a two-level atom. We show that squashed light does not mimic all aspects of squeezed light, and in particular, it does not produce the characteristic linear intensity dependence of the population of the upper-most level of the cascade three-level atom. Nevertheless, it has nonclassical transient effects in the de-excitation.Comment: 12 pages, 6 figure

Rapid purification of quantum systems by measuring in a feedback-controlled unbiased basis

Rapid-purification by feedback --- specifically, reducing the mean impurity faster than by measurement alone --- can be achieved by making the eigenbasis of the density matrix to be unbiased relative to the measurement basis. Here we further examine the protocol introduced by Combes and Jacobs [Phys.Rev.Lett. {\bf 96}, 010504 (2006)] involving continuous measurement of the observable $J_z$ for a $D$-dimensional system. We rigorously re-derive the lower bound $(2/3)(D+1)$ on the achievable speed-up factor, and also an upper bound, namely $D^2/2$, for all feedback protocols that use measurements in unbiased bases. Finally we extend our results to $n$ independent measurements on a register of $n$ qubits, and derive an upper bound on the achievable speed-up factor that scales linearly with $n$.Comment: v2: published versio

Classical Robustness of Quantum Unravellings

We introduce three measures which quantify the degree to which quantum systems possess the robustness exhibited by classical systems when subjected to continuous observation. Using these we show that for a fixed environmental interaction the level of robustness depends on the measurement strategy, or unravelling, and that no single strategy is maximally robust in all ways.Comment: 8 Pages, 2 figures, Version 2. Minor changes to wording for clarification and some references added. Accepted for publication in Europhysics Letter

Determination of maximal Gaussian entanglement achievable by feedback-controlled dynamics

We determine a general upper bound for the steady-state entanglement achievable by continuous feedback for systems of any number of bosonic degrees of freedom. We apply such a bound to the specific case of parametric interactions - the most common practical way to generate entanglement in quantum optics - and single out optimal feedback strategies that achieve the maximal entanglement. We also consider the case of feedback schemes entirely restricted to local operations and compare their performance to the optimal, generally nonlocal, schemes.Comment: 4 pages. Published versio

Rapid Measurement of Quantum Systems using Feedback Control

We introduce a feedback control algorithm that increases the speed at which a measurement extracts information about a $d$-dimensional system by a factor that scales as $d^2$. Generalizing this algorithm, we apply it to a register of $n$ qubits and show an improvement O(n). We derive analytical bounds on the benefit provided by the feedback and perform simulations that confirm that this speedup is achieved.Comment: 4 pages, 4 figures. V2: Minor correction

A personalised medicine approach for ponatinib-resistant chronic myeloid leukaemia.

BACKGROUND: Chronic myeloid leukaemia (CML) is characterised by the presence of a fusion driver oncogene, BCR-ABL1, which is a constitutive tyrosine kinase. Tyrosine kinase inhibitors (TKIs) are the central treatment strategy for CML patients and have significantly improved survival rates, but the T315I mutation in the kinase domain of BCR-ABL1 confers resistance to all clinically approved TKIs, except ponatinib. However, compound mutations can mediate resistance even to ponatinib and remain a clinical challenge in CML therapy. Here, we investigated a ponatinib-resistant CML patient through whole-genome sequencing (WGS) to identify the cause of resistance and to find alternative therapeutic targets. PATIENTS AND METHODS: We carried out WGS on a ponatinib-resistant CML patient and demonstrated an effective combination therapy against the primary CML cells derived from this patient in vitro. RESULTS: Our findings demonstrate the emergence of compound mutations in the BCR-ABL1 kinase domain following ponatinib treatment, and chromosomal structural variation data predicted amplification of BCL2. The primary CD34(+) CML cells from this patient showed increased sensitivity to the combination of ponatinib and ABT-263, a BCL2 inhibitor with a negligible effect against the normal CD34(+) cells. CONCLUSION: Our results show the potential of personalised medicine approaches in TKI-resistant CML patients and provide a strategy that could improve clinical outcomes for these patients

State and dynamical parameter estimation for open quantum systems

Following the evolution of an open quantum system requires full knowledge of its dynamics. In this paper we consider open quantum systems for which the Hamiltonian is ``uncertain''. In particular, we treat in detail a simple system similar to that considered by Mabuchi [Quant. Semiclass. Opt. 8, 1103 (1996)]: a radiatively damped atom driven by an unknown Rabi frequency $\Omega$ (as would occur for an atom at an unknown point in a standing light wave). By measuring the environment of the system, knowledge about the system state, and about the uncertain dynamical parameter, can be acquired. We find that these two sorts of knowledge acquisition (quantified by the posterior distribution for $\Omega$, and the conditional purity of the system, respectively) are quite distinct processes, which are not strongly correlated. Also, the quality and quantity of knowledge gain depend strongly on the type of monitoring scheme. We compare five different detection schemes (direct, adaptive, homodyne of the $x$ quadrature, homodyne of the $y$ quadrature, and heterodyne) using four different measures of the knowledge gain (Shannon information about $\Omega$, variance in $\Omega$, long-time system purity, and short-time system purity).Comment: 14 pages, 18 figure