859 research outputs found
Association of Cystic Medial Necrosis of the Aorta and Undiagnosed Thyroiditis [Scripta Medica]
We have recently seen two patients with cystic medial necrosis of the aorta. The first patient died of a dissecting aneurysm of the thoracic aorta. At autopsy, classical Hashimoto’s thyroiditis was discovered. The second patient died of a rupture of the ascending aorta. At autopsy, chronic thyroiditis was seen with multiple large germinal center and diffuse fibrosis. Neither patient was clinically suspected of thyroid dysfunction although the second patient had had a partial thyroidectomy in the remote past
Exotic Statistics for Strings in 4d BF Theory
After a review of exotic statistics for point particles in 3d BF theory, and
especially 3d quantum gravity, we show that string-like defects in 4d BF theory
obey exotic statistics governed by the 'loop braid group'. This group has a set
of generators that switch two strings just as one would normally switch point
particles, but also a set of generators that switch two strings by passing one
through the other. The first set generates a copy of the symmetric group, while
the second generates a copy of the braid group. Thanks to recent work of
Xiao-Song Lin, we can give a presentation of the whole loop braid group, which
turns out to be isomorphic to the 'braid permutation group' of Fenn, Rimanyi
and Rourke. In the context 4d BF theory this group naturally acts on the moduli
space of flat G-bundles on the complement of a collection of unlinked unknotted
circles in R^3. When G is unimodular, this gives a unitary representation of
the loop braid group. We also discuss 'quandle field theory', in which the
gauge group G is replaced by a quandle.Comment: 41 pages, many figures. New version has minor corrections and
clarifications, and some added reference
Carcinogenicity of hexavalent chromium
Hexavalent chromium (Cr(VI)), a commonly used industrial metal, is a well known human lung carcinogen. Epidemiology and animal studies suggest that the particulate Cr(VI) compounds, specifically the water insoluble compounds, are the more potent carcinogens, however, the carcinogenic mechanism remains unknown. Here we summarize recent Cr(VI)-induced human tumour, in vivo, cell culture and in vitro studies and put the data into context with three major paradigms of carcinogenesis: multistage carcinogenesis, genomic instability, and epigenetic modifications. Based on these studies, we propose a mechanism for chromate carcinogenesis that is primarily driven by the genomic instability paradigm
Resolving the Formation of Protogalaxies. III. Feedback from the First Stars
The first stars form in dark matter halos of masses ~10^6 M_sun as suggested
by an increasing number of numerical simulations. Radiation feedback from these
stars expels most of the gas from their shallow potential well of their
surrounding dark matter halos. We use cosmological adaptive mesh refinement
simulations that include self-consistent Population III star formation and
feedback to examine the properties of assembling early dwarf galaxies. Accurate
radiative transport is modeled with adaptive ray tracing. We include supernova
explosions and follow the metal enrichment of the intergalactic medium. The
calculations focus on the formation of several dwarf galaxies and their
progenitors. In these halos, baryon fractions in 10^8 solar mass halos decrease
by a factor of 2 with stellar feedback and by a factor of 3 with supernova
explosions. We find that radiation feedback and supernova explosions increase
gaseous spin parameters up to a factor of 4 and vary with time. Stellar
feedback, supernova explosions, and H_2 cooling create a complex, multi-phase
interstellar medium whose densities and temperatures can span up to 6 orders of
magnitude at a given radius. The pair-instability supernovae of Population III
stars alone enrich the halos with virial temperatures of 10^4 K to
approximately 10^{-3} of solar metallicity. We find that 40% of the heavy
elements resides in the intergalactic medium (IGM) at the end of our
calculations. The highest metallicity gas exists in supernova remnants and very
dilute regions of the IGM.Comment: 15 pages, 16 figures, accepted to ApJ. Many changes, including
estimates of metal line cooling. High resolution images and movies available
at http://www.slac.stanford.edu/~jwise/research/PGalaxies3
A Global Assessment of Gold, Titanium, Strontium and Barium Pollution Using Sperm Whales (Physeter Macrocephalus) As an Indicator Species
This study provides a global baseline for barium, gold, titanium and strontium as marine pollutants using the sperm whale (Physeter macrocephalus) as an indicator species. Barium, gold, titanium and strontium are metals that are little studied in marine environments. However, their recent emergence as nanomaterials will likely increase their presence in the marine environment. Moreover, nanosized particles are likely to exhibit toxic outcomes not seen in macrosized particles. Biopsies from free ranging sperm whales were collected from around the globe. Total barium levels were measured in 275 of 298 sperm whales tested for barium and collected from 16 regions around the globe. The global mean for barium was 0.93 +/- 0.2ug/g with a detectable range from 0.1 to 27.9ug. Total strontium levels were measurable in all 298 sperm whales producing a global mean level of 2.2 +/- 0.1ug/g and a range from 0.2 to 11.5ug/g. Total titanium levels were also measured in all 298 sperm whales producing a global mean level of 4.5 +/- 0.25ug/g with a range from 0.1 to 29.8ug/g. Total gold levels were detected in 50 of the 194 sperm whales collected from 16 regions around the globe. Detectable levels ranged from 0.1 to 2.3ug/g tissue with a global mean level equal to 0.2 +/- 0.02ug/g. Previous reports of these metals were much lower than the mean levels reported here. The likely explanation is location differences and consistent with this explanation, we found statistically significant variation among regions. These data provide an important global baseline for barium, gold, titanium and strontium pollution and will allow for important comparisons to be made over time to assess the impact of nanomaterials on whales and the marine environment
Inferred galaxy properties during Cosmic Dawn from early JWST photometry results
Early photometric results from JWST have revealed a number of galaxy
candidates above redshift 10. The initial estimates of inferred stellar masses
and the associated cosmic star formation rates are above most theoretical model
predictions up to a factor of 20 in the most extreme cases, while this has been
moderated after the recalibration of NIRCam and subsequent spectroscopic
detections. Using these recent JWST observations, we use galaxy scaling
relations from cosmological simulations to model the star formation history to
very high redshifts, back to a starting halo mass of 10^7 solar masses, to
infer the intrinsic properties of the JWST galaxies. Here we explore the
contribution of supermassive black holes, stellar binaries, and an excess of
massive stars to the overall luminosity of high-redshift galaxies. Despite the
addition of alternative components to the spectral energy distribution, we find
stellar masses equal to or slightly higher than previous stellar mass
estimates. Most galaxy spectra are dominated by the stellar component, and the
exact choice for the stellar population model does not appear to make a major
difference. We find that four of the 12 high-redshift galaxy candidates are
best fit with a non-negligible active galactic nuclei component, but the
evidence from the continuum alone is insufficient to confirm their existence.
Upcoming spectroscopic observations of z > 10 galaxies will confirm the
presence and nature of high-energy sources in the early universe and will
constrain their exact redshifts.Comment: 20 pages, 13 figures, 5 tables. Accepted by MNRAS. 12 figures, 13
tables in appendice
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