Nucleosomes in gene regulation: theoretical approaches

This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from molecular-mechanistic and biological point of view. In addition to classical problems of this field, actual questions of epigenetic regulation are discussed. The authors selected for discussion what seem to be the most interesting concepts and hypotheses. Mathematical approaches are described in a simplified language to attract attention to the most important directions of this field

Evaluation of a Pyrometric-based Temperature Measuring Process for the Laser Transmission Welding

An on-axis pyrometric-based temperature measurement method suitable for different laser transmission welding techniques is presented. A temperature detection during contour and quasi-simultaneous welding is demonstrated to fit the requirements of laser transmission welding with part adapted temperature fields. For the experiments a pyrometer is connected to a scanner optic with a non-color-corrected lens. The experiments are performed with a high-speed pyrometer detecting in spectral range of 1.65 - 2.1 μm. Potential errors caused by the measurement method are evaluated and its limits depend on the welding technique performed are examined by creating different defects in the weld seam