Which long-baseline neutrino experiments are preferable?

We discuss the physics of superbeam upgrades, where we focus on T2KK, a NuMI beam line based experiment NOvA*, and a wide band beam (WBB) experiment independent of the NuMI beam line. For T2KK, we find that the Japan-Korea baseline helps resolve parameter degeneracies, but the improvement due to correlated systematics between the two detectors (using identical detectors) is only moderate. For an upgrade of NOvA with a liquid argon detector, we demonstrate that the Ash River site is preferred compared to alternatives, such as at the second oscillation maximum, and is the optimal site within the U.S. For a WBB experiment, we find that high proton energies and long decay tunnels are preferable. We compare water Cherenkov and liquid argon technologies, and find the break-even point in detector cost at about 4:1. In order to compare the physics potential of the different experimental configurations, we use the concept of exposure to normalize the performance. We find that experiments with WBBs are the best experimental concept. NOvA* could be competitive with sufficient luminosity. If $\sin^2 2\theta_{13}$ > 0.01, a WBB experiment can perform better than a neutrino factory.Comment: 31 pages, 13 figures, 5 tables. Version to appear in PR

Rokhlin Dimension for Flows

This research was supported by GIF Grant 1137/2011, SFB 878 Groups, Geometry and Actions and ERC Grant No. 267079. Part of the research was conducted at the Fields institute during the 2014 thematic program on abstract harmonic analysis, Banach and operator algebras, and at the Mittag–Leffler institute during the 2016 program on Classification of Operator Algebras: Complexity, Rigidity, and Dynamics.Peer reviewedPostprin

Open Source Dataset and Machine Learning Techniques for Automatic Recognition of Historical Graffiti

Machine learning techniques are presented for automatic recognition of the historical letters (XI-XVIII centuries) carved on the stoned walls of St.Sophia cathedral in Kyiv (Ukraine). A new image dataset of these carved Glagolitic and Cyrillic letters (CGCL) was assembled and pre-processed for recognition and prediction by machine learning methods. The dataset consists of more than 4000 images for 34 types of letters. The explanatory data analysis of CGCL and notMNIST datasets shown that the carved letters can hardly be differentiated by dimensionality reduction methods, for example, by t-distributed stochastic neighbor embedding (tSNE) due to the worse letter representation by stone carving in comparison to hand writing. The multinomial logistic regression (MLR) and a 2D convolutional neural network (CNN) models were applied. The MLR model demonstrated the area under curve (AUC) values for receiver operating characteristic (ROC) are not lower than 0.92 and 0.60 for notMNIST and CGCL, respectively. The CNN model gave AUC values close to 0.99 for both notMNIST and CGCL (despite the much smaller size and quality of CGCL in comparison to notMNIST) under condition of the high lossy data augmentation. CGCL dataset was published to be available for the data science community as an open source resource.Comment: 11 pages, 9 figures, accepted for 25th International Conference on Neural Information Processing (ICONIP 2018), 14-16 December, 2018 (Siem Reap, Cambodia

Results from Super-Kamiokande

The recent results from Super-Kamiokande (SK) are reported. On atmospheric neutrino analysis, we have performed a full 3-flavor oscillation analysis with SK-I+II+III data. A CPT violation study on atmospheric neutrino is also done with SK-I+II+III data. On solar neutrino analysis, a 3-flavor oscillation analysis with SK-III data is performed.Comment: 6 pages, 8 figures, proceedings of The XXIV International Conference on Neutrino Physics and Astrophysics (Neutrino 2010

Telavancin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA)

Telavancin is a bactericidal lipoglycopeptide antibiotic that is structurally related to vancomycin. It demonstrates in vitro activity against a variety of Gram-positive pathogens including, but not limited to, methicillin-resistant Staphylococcus aureus (MRSA). Telavancin is currently FDA-approved for the treatment of complicated skin and skin-structure infections. Recently, two randomized clinical trials demonstrated the efficacy and safety of telavancin compared to vancomycin for the treatment of nosocomial pneumonia. Overall, telavancin has a favorable safety profile. However, mild gastrointestinal disturbances and reversible increases in serum creatinine were observed in clinical studies. Additional clinical studies are needed to evaluate telavancin’s efficacy and safety in comparison to other antistaphylococcal agents for the treatment of infections such as bacteremia and endocarditis

Conservation of a microRNA cluster in parasitic nematodes and profiling of miRNAs in excretory-secretory products and microvesicles of Haemonchus contortus

microRNAs are small non-coding RNAs that are important regulators of gene expression in a range of animals, including nematodes. We have analysed a cluster of four miRNAs from the pathogenic nematode species Haemonchus contortus that are closely linked in the genome. We find that the cluster is conserved only in clade V parasitic nematodes and in some ascarids, but not in other clade III species nor in clade V free-living nematodes. Members of the cluster are present in parasite excretory-secretory products and can be detected in the abomasum and draining lymph nodes of infected sheep, indicating their release in vitro and in vivo. As observed for other parasitic nematodes, H. contortus adult worms release extracellular vesicles (EV). Small RNA libraries were prepared from vesicle-enriched and vesicle-depleted supernatants from both adult worms and L4 stage larvae. Comparison of the miRNA species in the different fractions indicated that specific miRNAs are packaged within vesicles, while others are more abundant in vesicle-depleted supernatant. Hierarchical clustering analysis indicated that the gut is the likely source of vesicle-associated miRNAs in the L4 stage, but not in the adult worm. These findings add to the growing body of work demonstrating that miRNAs released from parasitic helminths may play an important role in host-parasite interactions

How a plantar pressure-based, tongue-placed tactile biofeedback modifies postural control mechanisms during quiet standing

The purpose of the present study was to determine the effects of a plantar pressure-based, tongue-placed tactile biofeedback on postural control mechanisms during quiet standing. To this aim, sixteen young healthy adults were asked to stand as immobile as possible with their eyes closed in two conditions of No-biofeedback and Biofeedback. Centre of foot pressure (CoP) displacements, recorded using a force platform, were used to compute the horizontal displacements of the vertical projection the centre of gravity (CoGh) and those of the difference between the CoP and the vertical projection of the CoG (CoP-CoGv). Altogether, the present findings suggest that the main way the plantar pressure-based, tongue-placed tactile biofeedback improves postural control during quiet standing is via both a reduction of the correction thresholds and an increased efficiency of the corrective mechanism involving the CoGh displacements

Hyperon Form Factors from N_f=2+1 QCD

We present results from the QCDSF/UKQCD collaboration for the electromagnetic and semi-leptonic form factors for the hyperons. The simulations are performed on our new ensembles generated with 2+1 flavours of dynamical O(a)-improved Wilson fermions. A unique feature of these configurations is that the quark masses are tuned so that the singlet quark mass is held fixed at its physical value. We use 5 such choices of the individual quark masses on 24^3x48 lattices with a lattice spacing of about 0.078 fm.Comment: 7 pages, 6 figures, 1 table. Talk presented at The XXVIII International Symposium on Lattice Field Theory, Villasimius, Italy, 14-19 June 201