Appropriating the Returns from Industrial Research and Development

macroeconomics, industrial research and development, patent law

Islets of Langerhans Are Protected from Inflammatory Cell Recruitment during Reperfusion of Rat Pancreas Grafts

Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors. However, it is unclear, whether exocrine and endocrine tissue experience similar inflammatory responses during pancreas transplantation (PTx). This study evaluated inflammatory susceptibilities of islets of Langerhans (ILH) and exocrine tissue after different preservation periods during early reperfusion. Methods: PTx was performed in rats following 2 h (2h-I) or 18 h (18h-I) preservation. Leukocyte-endothelial cell interactions (LEI) were analyzed in venules of acinar tissue and ILH in vivo over 2 h reperfusion. Nontransplanted animals served as controls. Tissue samples were analyzed by histomorphometry. Results: In exocrine venules leukocyte rolling predominated in the 2h-I group. In the 18h-I group, additionally, high numbers of adherent leukocytes were found. Histology revealed significant edema formation and leukocyte extravasation in the 18h-I group. Notably, LEI in postcapillary venules of ILH were significantly lower. Leukocyte rolling was only moderately enhanced and few leukocytes were found adherent. Histology revealed minor leukocyte extravasation. Conclusion: Ischemia time contributes decisively to the extent of the I/R-injury in PTx. However, ILH have a significantly lower susceptibility towards I/R, even when inflammatory reactions in adjacent exocrine tissue are evident. Copyright (C) 2010 S. Karger AG, Base

On the fidelity of two pure states

The fidelity of two pure states (also known as transition probability) is a symmetric function of two operators, and well-founded operationally as an event probability in a certain preparation-test pair. Motivated by the idea that the fidelity is the continuous quantum extension of the combinatorial equality function, we enquire whether there exists a symmetric operational way of obtaining the fidelity. It is shown that this is impossible. Finally, we discuss the optimal universal approximation by a quantum operation.Comment: LaTeX2e, 8 pages, submitted to J. Phys. A: Math. and Ge

Flight test evaluation of an RAF high altitude partial pressure protective assembly

A partial pressure suit was evaluated during tests in an F-104 and F-15 as a protective garment for emergency descents. The garment is an pressure jerkin and modified anti-g suit combined with an oronasal mask. The garment can be donned and doffed at the aircraft to minimize thermal buildup. The oronasal mask was favored by the pilots due to its immobility on the face during high g-loading. The garment was chosen to provide optimum dexterity for the pilot, which is not available in a full pressure suit, while protecting the pilot at altitudes up to 18,288 meters, during a cabin decompression, and subsequent aircraft descent. During cabin decompressions in the F-104 and F-15, cabin pressure altitude was measured at various aircraft angles of attack, Mach numbers, and altitudes to determine the effect of the aerodynamic slipstream on the cabin altitude

On the communication cost of entanglement transformations

We study the amount of communication needed for two parties to transform some given joint pure state into another one, either exactly or with some fidelity. Specifically, we present a method to lower bound this communication cost even when the amount of entanglement does not increase. Moreover, the bound applies even if the initial state is supplemented with unlimited entanglement in the form of EPR pairs, and the communication is allowed to be quantum mechanical. We then apply the method to the determination of the communication cost of asymptotic entanglement concentration and dilution. While concentration is known to require no communication whatsoever, the best known protocol for dilution, discovered by Lo and Popescu [Phys. Rev. Lett. 83(7):1459--1462, 1999], requires a number of bits to be exchanged which is of the order of the square root of the number of EPR pairs. Here we prove a matching lower bound of the same asymptotic order, demonstrating the optimality of the Lo-Popescu protocol up to a constant factor and establishing the existence of a fundamental asymmetry between the concentration and dilution tasks. We also discuss states for which the minimal communication cost is proportional to their entanglement, such as the states recently introduced in the context of ``embezzling entanglement'' [W. van Dam and P. Hayden, quant-ph/0201041].Comment: 9 pages, 1 figure. Added a reference and some further explanations. In v3 some arguments are given in more detai

Notes on multiplicativity of maximal output purity for completely positive qubit maps

A problem in quantum information theory that has received considerable attention in recent years is the question of multiplicativity of the so-called maximal output purity (MOP) of a quantum channel. This quantity is defined as the maximum value of the purity one can get at the output of a channel by varying over all physical input states, when purity is measured by the Schatten $q$-norm, and is denoted by $\nu_q$. The multiplicativity problem is the question whether two channels used in parallel have a combined $\nu_q$ that is the product of the $\nu_q$ of the two channels. A positive answer would imply a number of other additivity results in QIT. Very recently, P. Hayden has found counterexamples for every value of $q>1$. Nevertheless, these counterexamples require that the dimension of these channels increases with $1-q$ and therefore do not rule out multiplicativity for $q$ in intervals $[1,q_0)$ with $q_0$ depending on the channel dimension. I argue that this would be enough to prove additivity of entanglement of formation and of the classical capacity of quantum channels. More importantly, no counterexamples have as yet been found in the important special case where one of the channels is a qubit-channel, i.e. its input states are 2-dimensional. In this paper I focus attention to this qubit case and I rephrase the multiplicativity conjecture in the language of block matrices and prove the conjecture in a number of special cases.Comment: Manuscript for a talk presented at the SSPCM07 conference in Myczkowce, Poland, 10/09/2007. 12 page

Phonon spectral function for an interacting electron-phonon system

Using exact diagonalzation techniques, we study a model of interacting electrons and phonons. The spectral width of the phonons is found to be reduced as the Coulomb interaction U is increased. For a system with two modes per site, we find a transfer of coupling strength from the upper to the lower mode. This transfer is reduced as U is increased. These results give a qualitative explanation of differences between Raman and photoemission estimates of the electron-phonon coupling constants for A3C60 (A= K, Rb).Comment: 4 pages, RevTeX, 2 eps figur

Elemental Abundances of Nearby Galaxies through High Signal-to-Noise XMM-Newton Observations of ULXs

(abridged) In this paper, we examined XMM Newton EPIC spectra of 14 ultra-luminous X-ray sources (ULXs)in addition to the XMM RGS spectra of two sources (Holmberg II X-1 and Holmberg IX X-1). We determined oxygen and iron abundances of the host galaxy's interstellar medium (ISM) using K-shell (O) and L-shell (Fe) X-ray photo-ionization edges towards these ULXs. We found that the oxygen abundances closely matched recent solar abundances for all of our sources, implying that ULXs live in similar local environments despite the wide range of galaxy host properties. Also, we compare the X-ray hydrogen column densities (n_H) for 8 ULX sources with column densities obtained from radio H I observations. The X-ray model n_H values are in good agreement with the H I n_H values, implying that the hydrogen absorption towards the ULXs is not local to the source (with the exception of the source M81 XMM1). In order to obtain the column density and abundance values, we fit the X-ray spectra of the ULXs with a combined power law and one of several accretion disk models. We tested the abundances obtained from the XSPEC models bbody, diskbb, grad, and diskpn along with a power law, finding that the abundances were independent of the thermal model used. We comment on the physical implications of these different model fits. We also note that very deep observations allow a breaking of the degeneracy noted by Stobbart et al. (2006) favoring a high mass solution for the absorbed grad + power law model.Comment: 18 pages, accepted to Ap