Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study.

OBJECTIVES:Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and survival outcomes for R/M HNSCC in the real-world setting. MATERIALS AND METHODS:A multi-site retrospective chart review was conducted in Europe (Germany, United Kingdom, Italy, Spain), Asia Pacific (Australia, South Korea, Taiwan), and Latin/North America (Brazil and Canada) to identify patients who initiated first-line systemic therapy for R/M HNSCC between January 2011 and December 2013. Patients were followed through December 2015 to collect clinical characteristics, treatment and survival data. RESULTS:Among 733 R/M HNSCC patients across 71 sites, median age was 60 years (inter-quartile range 54-67), 84% male, and 70% Eastern Cooperative Oncology Group performance status 0-1; 32% had oral cavity and 30% oropharyngeal cancers. The most common first-line regimen across all countries consisted of platinum-based combinations (73%), including platinum + 5-fluorouracil (5-FU) (26%), cetuximab + platinum ± 5-FU (22%), or taxane + platinum ± 5-FU (16%). However, use of different platinum-based combinations varied substantially; administration of cetuximab + platinum ± 5-FU was frequent in Italy (81%), Germany (46%) and Spain (38%), whereas use in other countries was limited. Median follow-up was 22.6 months (95% confidence interval [CI]: 21.5-24.6 months). Median real-world overall survival was only 8.0 months (95% CI: 7.0-8.0), with one-year survival reaching only 30.9% (95% CI: 27.5-34.3). CONCLUSION:Systemic therapies used in clinical practice for patients with R/M HNSCC vary substantially across countries. Prognosis remains poor in this patient population, highlighting the need for newer, more efficacious treatments

The Vehicle, Fall 1985

Vol. 27, No. 1 Table of Contents Satchel AssMichael D. Smithpage 3 PhotoDoug Andersonpage 7 CounselingChristy Dunphypage 8 Grave SiteJay D. Fiskpage 8 Sight-Seeing Outside PhoenixBob Zordanipage 9 PerformanceDan Von Holtenpage 10 NightmareKandy Bellpage 10 Photo (The Loft)Lawrence McGownpage 11 LaboringJanet Gracepage 12 Blood DonorDan Von Holtenpage 13 Photo (Pier)Lawrence McGownpage 14 ExamplesChristopher Albinpage 14 Three PoemsPatrick Peterspage 15 Sometimes I Dream in Cotton CandyKathy Graypage 16 One Day While BoatingF. Link Rapierpage 17 DepartureBob Zordanipage 17 140 Print That\u27s Life Peter Dowlingpage 18 Photo (Around the Bend)Mike Freckerpage 20 Light ConversationDan Hintzpage 22 She Waits For the WorldJim Harrispage 22 HoneyKathy Graypage 23 Photo AlbumPatrick Peterspage 24 Photo (Stairs)Lawrence McGownpage 25 Fallen From Grace to SaturdayF. Link Rapierpage 26 Post MortemF. Link Rapierpage 27 ConfessionJohn Kayserpage 27 Child\u27s PlayChristopher Albinpage 27 Seeking A Friend\u27s Advice on DietingKathy Graypage 28 PhotoDoug Andersonpage 28 She Came Back to MeJim Harrispage 29 Farm BoyDiana Winsonpage 30 DilemmaJanet Wilhelmpage 31 In a Rock or StoneRichard Donnellypage 32 In November He Came To MeJean Kover Chandlerpage 33 EndingChristy Dunphypage 34 The Honor GradEddie Simpsonpage 35 Photo (Thirst)Mike Freckerpage 40https://thekeep.eiu.edu/vehicle/1046/thumbnail.jp

Understanding Characteristics, Treatment Patterns, and Clinical Outcomes for Individuals with Advanced or Recurrent Endometrial Cancer in Alberta, Canada: A Retrospective, Population-Based Cohort Study

Endometrial cancer (EC) incidence has increased in recent decades. However, population-based outcomes data are limited. In this retrospective cohort study, we examined characteristics, treatment patterns, and clinical outcomes, including time to next treatment (TNNT) and overall survival (OS), among advanced/recurrent (A/R) EC patients between 2010 and 2018 in Alberta, Canada. Kaplan–Meier statistics evaluated TTNT and OS, stratified by patient (A/R) and treatment. A total of 1053 patients were included: 620 (58.9%) advanced and 433 (41.1%) recurrent. A total of 713 (67.7%) patients received first-line therapy: 466 (75.2%) advanced and 247 (57.0%) recurrent. Platinum-based chemotherapy (PBCT) was the most common first-line regimen (overall: 78.6%; advanced: 96.1%; recurrent: 45.3%). The median TTNT and OS from first-line therapy were 19.9 months (95% confidence interval [CI]: 17.5–23.5) and 35.9 months (95% CI: 31.5–53.5), respectively. Following first-line PBCT, the median OS from second-line chemotherapy (N = 187) was 10.4 months (95% CI: 8.9–13.3) and higher for those rechallenged with PBCT (N = 72; 38.5%) versus no rechallenge (N = 115; 61.5%) (13.3 months [95% CI: 11.2–20.9] vs. 6.4 months [95% CI: 4.6–10.4; p < 0.001]). The findings highlight poor outcomes in A/R EC, particularly following first-line therapy, and that additional tolerable therapeutic options are needed to improve patient outcomes

The Vehicle, Fall 1985

Vol. 27, No. 1 Table of Contents Satchel AssMichael D. Smithpage 3 PhotoDoug Andersonpage 7 CounselingChristy Dunphypage 8 Grave SiteJay D. Fiskpage 8 Sight-Seeing Outside PhoenixBob Zordanipage 9 PerformanceDan Von Holtenpage 10 NightmareKandy Bellpage 10 Photo (The Loft)Lawrence McGownpage 11 LaboringJanet Gracepage 12 Blood DonorDan Von Holtenpage 13 Photo (Pier)Lawrence McGownpage 14 ExamplesChristopher Albinpage 14 Three PoemsPatrick Peterspage 15 Sometimes I Dream in Cotton CandyKathy Graypage 16 One Day While BoatingF. Link Rapierpage 17 DepartureBob Zordanipage 17 140 Print That\u27s Life Peter Dowlingpage 18 Photo (Around the Bend)Mike Freckerpage 20 Light ConversationDan Hintzpage 22 She Waits For the WorldJim Harrispage 22 HoneyKathy Graypage 23 Photo AlbumPatrick Peterspage 24 Photo (Stairs)Lawrence McGownpage 25 Fallen From Grace to SaturdayF. Link Rapierpage 26 Post MortemF. Link Rapierpage 27 ConfessionJohn Kayserpage 27 Child\u27s PlayChristopher Albinpage 27 Seeking A Friend\u27s Advice on DietingKathy Graypage 28 PhotoDoug Andersonpage 28 She Came Back to MeJim Harrispage 29 Farm BoyDiana Winsonpage 30 DilemmaJanet Wilhelmpage 31 In a Rock or StoneRichard Donnellypage 32 In November He Came To MeJean Kover Chandlerpage 33 EndingChristy Dunphypage 34 The Honor GradEddie Simpsonpage 35 Photo (Thirst)Mike Freckerpage 40https://thekeep.eiu.edu/vehicle/1046/thumbnail.jp