One Hundred Voices: Harrisburg’s Historic African American Community, 1850-1920

In 2020, a coalition of citizens, organizers, legislators, and educators came together to commemorate the Fifteenth and Nineteenth Amendments by establishing a new monument in Harrisburg, Pennsylvania. This would be a memorial dedicated to the capital city’s significant African American community and its historic struggle for the vote. The Commonwealth Monument, located on the Irvis Equality Circle on the South Lawn of Pennsylvania’s State Capitol Grounds, features a bronze pedestal inscribed with one hundred names of change agents who pursued the power of suffrage and citizenship between 1850 and 1920. This book is a companion to this monument and tells the stories of those one hundred freedom seekers, abolitionists, activists, suffragists, moralists, policemen, masons, doctors, lawyers, musicians, poets, publishers, teachers, preachers, housekeepers, janitors, and business leaders, among many others. In their committed advocacy for freedom, equality, and justice, these inspiring men and women made unique and lasting contributions to the standing and life of African Americans—and, indeed, the political power of all Americans—within their local communities and across the country. Calobe Jackson, Jr., is an historian of Harrisburg African American studies, Katie Wingert McArdle is a writer and researcher currently serving as the head swim coach at Dickinson College, and David Pettegrew is a professor of history at Messiah University. ~ This book emerged at the intersection of the Commonwealth Monument Project (for more on that go here) and the Digital Harrisburg project (for more on that go here). This work is continuing. For example, check out the work of the Digital Harrisburg team discussing the region’s difficult history of racial injustice here.https://commons.und.edu/press-books/1016/thumbnail.jp

Mass and Angular Momentum Transfer in the Massive Algol Binary RY Persei

We present an investigation of H-alpha emission line variations observed in the massive Algol binary, RY Per. We give new radial velocity data for the secondary based upon our optical spectra and for the primary based upon high dispersion UV spectra. We present revised orbital elements and an estimate of the primary's projected rotational velocity (which indicates that the primary is rotating 7 times faster than synchronous). We use a Doppler tomography algorithm to reconstruct the individual primary and secondary spectra in the region of H-alpha, and we subtract the latter from each of our observations to obtain profiles of the primary and its disk alone. Our H-alpha observations of RY Per show that the mass gaining primary is surrounded by a persistent but time variable accretion disk. The profile that is observed outside-of-eclipse has weak, double-peaked emission flanking a deep central absorption, and we find that these properties can be reproduced by a disk model that includes the absorption of photospheric light by the band of the disk seen in projection against the face of the star. We developed a new method to reconstruct the disk surface density distribution from the ensemble of H-alpha profiles observed around the orbit, and this method accounts for the effects of disk occultation by the stellar components, the obscuration of the primary by the disk, and flux contributions from optically thick disk elements. The resulting surface density distribution is elongated along the axis joining the stars, in the same way as seen in hydrodynamical simulations of gas flows that strike the mass gainer near trailing edge of the star. This type of gas stream configuration is optimal for the transfer of angular momentum, and we show that rapid rotation is found in other Algols that have passed through a similar stage.Comment: 39 pages, 12 figures, ApJ in press, 2004 June 20 issu

Binary and Multiple O-Type Stars in the Cas OB6 Association

We present the results of time-resolved spectroscopy of 13 O-type stars in the Cas OB6 stellar association. We conducted a survey for radial velocity variability in search of binary systems, which are expected to be plentiful in young OB associations. Here we report the discovery of two new single-lined binaries, and we present new orbital elements for three double-lined binaries (including one in the multiple star system HD 17505). One of the double-lined systems is the eclipsing binary system DN Cas, and we present a preliminary light curve analysis that yields the system inclination, masses, and radii. We compare the spectra of the single stars and the individual components of the binary stars with model synthetic spectra to estimate the stellar effective temperatures, gravities, and projected rotational velocities. We also make fits of the spectral energy distributions to derive E(B-V), R=A_V/E(B-V), and angular diameter. A distance of 1.9 kpc yields radii that are consistent with evolutionary models. We find that 7 of 14 systems with spectroscopic data are probable binaries, consistent with the high binary frequency found for other massive stars in clusters and associations.Comment: 40 pages, ApJ, in pres

3D printing of twisting and rotational bistable structures with tuning elements

Three-dimensional (3D) printing is ideal for the fabrication of various customized 3D components with fine details and material-design complexities. However, most components fabricated so far have been static structures with fixed shapes and functions. Here we introduce bistability to 3D printing to realize highly-controlled, reconfigurable structures. Particularly, we demonstrate 3D printing of twisting and rotational bistable structures. To this end, we have introduced special joints to construct twisting and rotational structures without post-assembly. Bistability produces a well-defined energy diagram, which is important for precise motion control and reconfigurable structures. Therefore, these bistable structures can be useful for simplified motion control in actuators or for mechanical switches. Moreover, we demonstrate tunable bistable components exploiting shape memory polymers. We can readjust the bistability-energy diagram (barrier height, slope, displacement, symmetry) after printing and achieve tunable bistability. This tunability can significantly increase the use of bistable structures in various 3D-printed components

BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin

Hemojuvelin (Hjv), a member of the repulsive-guidance molecule (RGM) family, upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Mammalian models have identified furin, neogenin, and matriptase-2 as modifiers of Hjv's function. Using the zebrafish model, we evaluated the effects of hjv and its interacting proteins on hepcidin expression during embryonic development. We found that hjv is strongly expressed in the notochord and somites of the zebrafish embryo and that morpholino knockdown of hjv impaired the development of these structures. Knockdown of hjv or other hjv-related genes, including zebrafish orthologs of furin or neogenin, however, failed to decrease hepcidin expression relative to liver size. In contrast, overexpression of bmp2b or knockdown of matriptase-2 enhanced the intensity and extent of hepcidin expression in zebrafish embryos, but this occurred in an hjv-independent manner. Furthermore, we demonstrated that zebrafish hjv can activate the human hepcidin promoter and enhance BMP responsive gene expression in vitro, but is expressed at low levels in the zebrafish embryonic liver. Taken together, these data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hjv

CHARA Array K'-band Measurements of the Angular Dimensions of Be Star Disks

We present the first K'-band, long-baseline interferometric observations of the northern Be stars gamma Cas, phi Per, zeta Tau, and kappa Dra. The measurements were made with multiple telescope pairs of the CHARA Array interferometer, and in every case the observations indicate that the circumstellar disks of the targets are resolved. We fit the interferometric visibilities with predictions from a simple disk model that assumes an isothermal gas in Keplerian rotation. We derive fits of the four model parameters (disk base density, radial density exponent, disk normal inclination, and position angle) for each of the targets. The resulting densities are in broad agreement with prior studies of the IR excess flux and the resulting orientations generally agree with those from interferometric H-alpha and continuum polarimetric observations. We find that the angular size of the K' disk emission is smaller than that determined for the H-alpha emission, and we argue that the difference is the result of a larger H-alpha opacity and the relatively larger neutral hydrogen fraction with increasing disk radius. All the targets are known binaries with faint companions, and we find that companions appear to influence the interferometric visibilities in the cases of phi Per and kappa Dra. We also present contemporaneous observations of the H-alpha, H-gamma, and Br-gamma emission lines. Synthetic model profiles of these lines that are based on the same disk inclination and radial density exponent as derived from the CHARA Array observations match the observed emission line strength if the disk base density is reduced by approximately 1.7 dex.Comment: ApJ in press (2007 Jan 1), 55 pages, 14 figure

Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function

Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m2), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10−7) and FNDC1 (p-value = 3.0×10−7) for UACR, and KCNQ1 with eGFR (p = 3.6×10−6). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish

Somatosensory processing in neurodevelopmental disorders

The purpose of this article is to review the role of somatosensory perception in typical development, its aberration in a range of neurodevelopmental disorders, and the potential relations between tactile processing abnormalities and central features of each disorder such as motor, communication, and social development. Neurodevelopmental disorders that represent a range of symptoms and etiologies, and for which multiple peer-reviewed articles on somatosensory differences have been published, were chosen to include in the review. Relevant studies in animal models, as well as conditions of early sensory deprivation, are also included. Somatosensory processing plays an important, yet often overlooked, role in typical development and is aberrant in various neurodevelopmental disorders. This is demonstrated in studies of behavior, sensory thresholds, neuroanatomy, and neurophysiology in samples of children with Fragile X syndrome, autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and cerebral palsy (CP). Impaired somatosensory processing is found in a range of neurodevelopmental disorders and is associated with deficits in communication, motor ability, and social skills in these disorders. Given the central role of touch in early development, both experimental and clinical approaches should take into consideration the role of somatosensory processing in the etiology and treatment of neurodevelopmental disorders