Natural History of HPV Infection Across the Lifespan: Role of Viral Latency.

Large-scale epidemiologic studies have been invaluable for elaboration of the causal relationship between persistent detection of genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. However, these studies provide limited data to adequately inform models of the individual-level natural history of HPV infection over the course of a lifetime, and particularly ignore the biological distinction between HPV-negative tests and lack of infection (i.e., the possibility of latent, undetectable HPV infection). Using data from more recent epidemiological studies, this review proposes an alternative model of the natural history of genital HPV across the life span. We argue that a more complete elucidation of the age-specific probabilities of the alternative transitions is highly relevant with the expanded use of HPV testing in cervical cancer screening. With routine HPV testing in cervical cancer screening, women commonly transition in and out of HPV detectability, raising concerns for the patient and the provider regarding the source of the positive test result, its prognosis, and effective strategies to prevent future recurrence. Alternative study designs and analytic frameworks are proposed to better understand the frequency and determinants of these transition pathways

Using Theory to Guide Exploratory Network Analyses

The use of exploratory network analysis has increased in psychopathology research over the past decade. A benefit of exploratory network analysis is the wealth of information it can provide; however, a single analysis may generate more inferences than what can be discussed in one manuscript (e.g., centrality indices of each node). This necessitates that authors choose which results to discuss in further detail and which to omit. Without a guide for this process, the likelihood of a biased interpretation is high. We propose that the integration of theory throughout the research process makes the interpretation of exploratory networks more manageable for the researcher and more likely to result in an interpretation that advances science. The goals of this paper are to differentiate between exploratory and confirmatory network analyses, discuss the utility of exploratory work, and provide a practical framework that uses theory as a guide to interpret exploratory network analyses

Perancangan Dan Pembuatan Sistem Penggajian Karyawan CV. Inti Daya Engineering

CV. Inti Daya Engineering adalah Perusahaan yang bergerak di bidang persewaan Generator Set, pengolahan plat dan pembuatan silent canopy untuk Generator Set. Pada saat ini, sistem penggajian karyawan di CV. Inti Daya Engineering masih dilakukan secara manual. Rekap data absensi karyawan pun masih dihitung secara manual. Pencatatan secara manual akan menyulitkan HRD karena tiap bulan harus mengumpulkan tiap form yang ada lalu disesuaikan dengan karyawan yang bersangkutan untuk dihitung besar gajinya. Jika ada dokumen yang lupa dicatat, ataupun hilang maka akan membutuhkan waktu yang lama karena harus disesuaikan dengan catatan kerja karyawan dan lain sebagainya.Berdasarkan latar belakang permasalahan tersebut, maka dirancang sebuah Sistem Penggajian Karyawan. Hasil yang diperoleh dari aplikasi yang telah dibuat antara lain dapat menyimpan segala data yang diperlukan untuk perhitungan gaji dimulai dari data absensi, komponen khusus, cuti karyawan, pinjaman ke Perusahaan, data pajak, rekap data absensi per bulan secara otomatis, perhitungan gaji karyawan secara otomatis, perhitungan pajak per bulan dan lampiran SPT 1721 – A1 untuk karyawan

A Network Approach to Understanding Narcissistic Grandiosity via the Narcissistic Admiration and Rivalry Questionnaire and the Narcissistic Personality Inventory

The narcissistic admiration and rivalry concept (NARC) model of grandiose narcissism posits that striving for uniqueness, grandiose fantasies, and charmingness define narcissistic admiration, whereas striving for supremacy, devaluation, and aggressiveness define narcissistic rivalry. Given these complex interrelationships, we explored the structure of grandiose narcissism using the Narcissistic Admiration and Rivalry Questionnaire (NARQ) and Narcissistic Personality Inventory (NPI) via network analysis in four separate samples which allowed us to assess the extent to which these networks replicated across these samples (total N = 3,868). Overall, grandiose cognitions from the NARQ emerged as a highly central node in each network, providing compound evidence for its replicability and generalizability as an important feature of grandiose narcissism within the NARC model. Charmingness from the NARQ emerged as a central node throughout Samples 1, 2, and 3, with strong connections to features of narcissistic admiration and narcissistic rivalry (e.g., grandiose fantasies and aggressiveness), but was less central in Sample 4. To our knowledge, this is the first research to examine the replicability of the network structure of grandiose narcissism across various samples. These findings add to an increasingly important dialogue regarding replicability in psychological network science

A Dark Web of Personality: Network Analyses of Dark Personality Features and Pathological Personality Traits

Network analysis offers an opportunity to gain a more nuanced view of the connections between the darker aspects of personality by examining the interrelationships between the components that make up these constructs. We examined the associations that five dark personality dispositions (i.e., narcissism, Machiavellianism, psychopathy, sadism, and spitefulness) had with pathological personality traits (i.e., antagonism, disinhibition, detachment, negative affectivity, and psychoticism) via network analysis. These dark personality networks were examined in four studies (N = 1,800), wherein the second study attempted to replicate the network from the first study, while the last two studies incorporated more specific and independent measures of dark personality features (e.g., grandiose and vulnerable narcissism). Although there were differences across network structures in these studies, the pathological personality trait of antagonism consistently evinced high expected influence centrality (i.e., it was the most strongly connected and possibly influential trait in each network). Our discussion focuses on the implications of these results for the understanding of the connections between the darker aspects of personality

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study

Immunoterapia; Pembrolizumab; neoplàsies mamàries triple-negativesInmunoterapia; Pembrolizumab; neoplasias mamarias triple-negativasImmunotherapy; Pembrolizumab; triple-negative breast neoplasmsBackground: Treatment options for previously treated metastatic triple-negative breast cancer (mTNBC) are limited. In cohort A of the phase II KEYNOTE-086 study, we evaluated pembrolizumab as second or later line of treatment for patients with mTNBC. Patients and methods: Eligible patients had centrally confirmed mTNBC, ?1 systemic therapy for metastatic disease, prior treatment with anthracycline and taxane in any disease setting, and progression on or after the most recent therapy. Patients received pembrolizumab 200mg intravenously every 3 weeks for up to 2 years. Primary end points were objective response rate in the total and PD-L1–positive populations, and safety. Secondary end points included duration of response, disease control rate (percentage of patients with complete or partial response or stable disease for ?24 weeks), progression-free survival, and overall survival. Results: All enrolled patients (N¼170) were women, 61.8% had PD-L1–positive tumors, and 43.5% had received ?3 previous lines of therapy for metastatic disease. ORR (95% CI) was 5.3% (2.7–9.9) in the total and 5.7% (2.4–12.2) in the PD-L1–positive populations. Disease control rate (95% CI) was 7.6% (4.4–12.7) and 9.5% (5.1–16.8), respectively. Median duration of response was not reached in the total (range, 1.2þ–21.5þ) and in the PD-L1–positive (range, 6.3–21.5þ) populations. Median PFS was 2.0 months (95% CI, 1.9–2.0), and the 6-month rate was 14.9%. Median OS was 9.0 months (95% CI, 7.6–11.2), and the 6-month rate was 69.1%. Treatment-related adverse events occurred in 103 (60.6%) patients, including 22 (12.9%) with grade 3 or 4 AEs. There were no deaths due to AEs. Conclusions: Pembrolizumab monotherapy demonstrated durable antitumor activity in a subset of patients with previously treated mTNBC and had a manageable safety profile.This work was supported by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA

Global Standards in Action: Insights from Anti-Money Laundering Regulation

As organizations have come under the increasing influence of global rules of all sorts, organization scholars have started studying the dynamics of global regulation. The purpose of this article is to identify and evaluate the contribution to this interdisciplinary field by the ‘Stockholm Centre for Organisational Research’. The latter’s key proposition is that while global regulation often consists of voluntary best practice rules it can nevertheless become highly influential under certain conditions. We assess how innovative this approach is using as a benchmark the state of the art in another field of relevance to the study of global regulation, i.e. ‘International Relations’. Our discussion is primarily theoretical but we draw on the case of global anti-money laundering regulation to illustrate our arguments and for inspirations of how to further elaborate the approach