Validation of a rapid and sensitive LC-MS/ MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17-O-β-D-glucuronide: Application to human pharmacokinetics study

10.1371/journal.pone.0118553PLoS ONE103e011855

Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients

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FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway

10.3390/cancers11060836Cancers116836-83

Exemestane major metabolism pathway.

<p>Exemestane major metabolism pathway.</p

Product ion mass spectra of (a) Exe (b) 17DhExe and (c) Exe17Oglu.

<p>Product ion mass spectra of (a) Exe (b) 17DhExe and (c) Exe17Oglu.</p

Mean concentrations of a) Exe (b) 17DhExe and (c) Exe17Oglu in plasma samples of one representative breast cancer patient.

<p>Mean concentrations of a) Exe (b) 17DhExe and (c) Exe17Oglu in plasma samples of one representative breast cancer patient.</p

Accuracy and Precision of Dilution Procedure for Exe.

<p>*Expressed as mean percentage (n = 4) of the mean value measured over the nominal value</p><p>^#Expressed as percentage of the standard deviation divided by the mean</p><p>Accuracy and Precision of Dilution Procedure for Exe.</p

Representative chromatograms of (a) Exe (b) 17DhExe and (c) Exe17Oglu at LLOQ and (a) Exe-d3, (b) DhExe-d3 as well as Exe17Oglu at 100 ng/mL as internal standards.

<p>Representative chromatograms of (a) Exe (b) 17DhExe and (c) Exe17Oglu at LLOQ and (a) Exe-d3, (b) DhExe-d3 as well as Exe17Oglu at 100 ng/mL as internal standards.</p

A novel combinatorial strategy using Seliciclib (R) and Belinostat (R) for eradication of non-small cell lung cancer via apoptosis induction and BID activation

10.1016/j.canlet.2016.07.023CANCER LETTERS381149-57NETHERLAND