In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues-1

<p><b>Copyright information:</b></p><p>Taken from "In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues"</p><p>BMC Genomics 2006;7():86-86.</p><p>Published online 21 Apr 2006</p><p>PMCID:PMC1462998.</p><p>Copyright © 2006 Pao et al; licensee BioMed Central Ltd.</p>croarray from GNF SymAtlas [32] are indicated by the lines and the number (#) of genes by the bars

In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues-3

<p><b>Copyright information:</b></p><p>Taken from "In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues"</p><p>BMC Genomics 2006;7():86-86.</p><p>Published online 21 Apr 2006</p><p>PMCID:PMC1462998.</p><p>Copyright © 2006 Pao et al; licensee BioMed Central Ltd.</p>as a consequence of their divergent level of expression in the thymus). (B) and (C) microarray data for mouse (B) and human (C) [32], which also showed this discrepancy. In mouse, the expression of this gene in the thymus was more than 10 times the median value, while, in humans, it was around the median, much lower than the value of 3 times the median, the level generally used as the threshold for preferential expression. (B) and (C) were exported from GNF SymAtlas [32]

In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues-0

<p><b>Copyright information:</b></p><p>Taken from "In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues"</p><p>BMC Genomics 2006;7():86-86.</p><p>Published online 21 Apr 2006</p><p>PMCID:PMC1462998.</p><p>Copyright © 2006 Pao et al; licensee BioMed Central Ltd.</p

In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues-5

<p><b>Copyright information:</b></p><p>Taken from "In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues"</p><p>BMC Genomics 2006;7():86-86.</p><p>Published online 21 Apr 2006</p><p>PMCID:PMC1462998.</p><p>Copyright © 2006 Pao et al; licensee BioMed Central Ltd.</p> extracted. For triplets with records containing the same description under both tissue and organ or no record for one, but not both, the library can be automatically classified into the category described in the tissue/organ field. This automatic assignment was then checked with title to avoid omission of useful information, such as disease state, that could be hidden in the title fields. In some cases (case 2 and 4), the tissue and organ fields were different or both were empty. If different, the library was temporarily classified according to tissue, then modified manually if the other two fields contained more information that could be used for the modification. If both were null, the classification relied on the title

In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues-2

<p><b>Copyright information:</b></p><p>Taken from "In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues"</p><p>BMC Genomics 2006;7():86-86.</p><p>Published online 21 Apr 2006</p><p>PMCID:PMC1462998.</p><p>Copyright © 2006 Pao et al; licensee BioMed Central Ltd.</p

In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues-4

<p><b>Copyright information:</b></p><p>Taken from "In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues"</p><p>BMC Genomics 2006;7():86-86.</p><p>Published online 21 Apr 2006</p><p>PMCID:PMC1462998.</p><p>Copyright © 2006 Pao et al; licensee BioMed Central Ltd.</p>ood vessel (r = -0.96), and (B) human and its mouse ortholog , showing that the main discrepancy is in three brain tissues (r = -0.87)

Spatial distributions of AUC and <i>S</i>_<i>F</i> for dextrans and doxorubicin in a subcutaneous tumor.

<p>A: The spatial distribution of 10-kDa, 70-kDa, 2-MDa dextrans and doxorubicin. B: The corresponding spatial distribution of the cell survival rates. The 2-cm (<i>R</i> = 1 cm) tumor with a 0.8-cm (<i>R</i>_<i>n</i> = 0.4<i>R</i>) necrotic region was immersed in a 1 cm thick normal tissues.</p

Hydrodynamic distributions based on the <i>S</i>/<i>V</i> and <i>S</i>_<i>L</i>/<i>V</i> distributions in Fig 2A and parameters listed in Table 1.

<p>Distributions of A: <i>P</i>_<i>i</i>, B: <i>u</i>_<i>i</i> and C: <i>ϕ</i>_<i>B</i> (according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189802#pone.0189802.e003" target="_blank">Eq (2)</a>), <i>ϕ</i>_<i>L</i> (according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189802#pone.0189802.e004" target="_blank">Eq (3)</a>), and their sum in a 2-cm subcutaneous (<i>R</i>_<i>n</i> = 0.4<i>R</i>) tumor.</p

The concentration contours showing time evolution of dextrans and doxorubicin distributions in a subcutaneous tumor.

<p>A: 10 kDa dextran, B: 70 kDa dextran, C: 2 MDa dextran and D: doxorubicin. The smallest contour value <i>C</i>/<i>C</i>_max = 0.005 is marked.</p

Hydrodynamic parameter values for tumor tissues of isolated and subcutaneous tumors as well as for normal tissues surrounding a subcutaneous tumor [22, 32].

<p>Hydrodynamic parameter values for tumor tissues of isolated and subcutaneous tumors as well as for normal tissues surrounding a subcutaneous tumor [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189802#pone.0189802.ref022" target="_blank">22</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189802#pone.0189802.ref032" target="_blank">32</a>].</p