1 research outputs found
Synthesis and Evaluation of <i>N</i>‑Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV)
Small
molecule induced hepatitis B virus (HBV) capsid assembly
modulation is considered an attractive approach for new antiviral
therapies against HBV. Here we describe efforts toward the discovery
of a HBV capsid assembly modulator in a hit-to-lead optimization,
resulting in JNJ-632, a tool compound used to further profile the
mode of action. Administration of JNJ-632 (<b>54</b>) in HBV
genotype D infected chimeric mice resulted in a 2.77 log reduction
of the HBV DNA viral load