Quokka: An Open-source Large Language Model ChatBot for Material Science

This paper presents the development of a specialized chatbot for materials science, leveraging the Llama-2 language model, and continuing pre-training on the expansive research articles in the materials science domain from the S2ORC dataset. The methodology involves an initial pretraining phase on over one million domain-specific papers, followed by an instruction-tuning process to refine the chatbot's capabilities. The chatbot is designed to assist researchers, educators, and students by providing instant, context-aware responses to queries in the field of materials science. We make the four trained checkpoints (7B, 13B, with or without chat ability) freely available to the research community at https://github.com/Xianjun-Yang/Quokka.Comment: Work in progres

Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema.

Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema. We show a single dose of a monoclonal antibody against beta1 integrin induced both functional and structural reversal of elastase-induced lung injury in vivo, and we found that similar matrix remodelling changes occurred in human lung tissue. We also identified a potential mechanism of action as this allosteric modulation of beta1 integrin inhibited elastase-induced caspase activation, F-actin aggregate formation and changes in cellular ATP levels. This was accompanied by maintenance of beta1?integrin levels and inhibition of caveolin-1 phosphorylation. We propose that allosteric modulation of beta1 integrin-mediated mechanosensing prevents cell death associated with lung injury and progressive emphysema, thus allowing cells to survive and for repair and regeneration to ensue

Optimal control for halo orbit missions

This paper addresses the computation of the required trajectory correction maneuvers (TCM) for a halo orbit space mission to compensate for the launch velocity errors introduced by inaccuracies of the launch vehicle. By combiningdynamical systems theory with optimal control techniques, we produce a portrait of the complex landscape of the trajectory design space. This approach enables parametric studies not available to mission designers a few years ago, such as how the magnitude of the errors and the timingof the first TCM affect the correction ΔV. The impetus for combiningdynamical systems theory and optimal control in this problem arises from design issues for the Genesis Discovery mission being developed for NASA by the Jet Propulsion Laboratory

Chronicles of Oklahoma

Notes and Document section from Volume 84, Number 2, Summer 2006. It includes an article honoring the individuals who were inducted into the annual Oklahoma Historians Hall of Fame in 2006. The honorees in April 2006 were Joe C. Jackson, Denzil D. Garrison, Alice Tyner Timmons, and Robert "Bob" F. Read, Sr

Chronicles of Oklahoma

Notes and Documents section from Volume 85, Number 1, Spring 2007. It includes an article honoring the individuals who were inducted into the annual Oklahoma Historians Hall of Fame in 2007. The Oklahoma Historical Society selects recipients based on their contributions to the preservation, collection, interpretation, and dissemination of Oklahoma history. The honorees in 2007 were W. David Baird and Guy W. Logsdon

Chronicles of Oklahoma

Notes and Document section from Volume 86, Number 1, Spring 2008. It includes an article honoring the individuals who were inducted into the annual Oklahoma Historians Hall of Fame in 2008. The honorees included in this issue are Danney G. Goble and Odie B. Faulk. The other two honorees, Lawrence Hart and Bob Klemme, appear in the Summer 2008 issue

Chronicles of Oklahoma

Notes and Document section from Volume 86, Number 2, Summer 2008. It includes an article honoring the individuals who were inducted into the annual Oklahoma Historians Hall of Fame in 2008. The honorees included in this issue are Lawrence Hart and Bob Klemme. The other two honorees, Danney G. Goble and Odie B. Faulk, appeared in the Spring 2008 issue

Elementary Administrators\u27 Exploring the Factors that Promote or Inhibit Reading Achievement

The purpose of this study was to explore the factors that promote or inhibit the reading achievement of elementary children. The participants for this study were administrators who were employed at eleven Title I schools in North Carolina. The study used a qualitative design and collected data by phone interviews with elementary administrators. Several recurring themes and patterns surfaced from the data gathered from the eleven participants. However, the overarching themes that promoted reading achievement were (a) family support, (b) early literacy exposure, and (c) teacher effectiveness and expectations. The reoccurring themes that inhibited reading achievement were (a) lack of early literacy exposure, (b) lack of family support, and (c) lack of teacher and parental expectations

Chronicles of Oklahoma

Notes and Document section from Volume 85, Number 2, Summer 2007. It includes the "Oklahoma Historians Hall of Fame: Pendleton Woods and Martin A. Hagerstrand" which honors Pendleton Woods and Martin A. Hagerstrand's inductions into the Oklahoma Historian Hall of Fame in April 2007. It also includes Dianna Everett's "1950s Oklahoma in the Hillerman Photographs" which details the Barney Hillerman Collection of photographs that is held by the Oklahoma Historical Society and includes a selection of the digitized photographs that capture the essence of the 1950s era in Oklahoma history

Inclusive teaching circles : mechanisms for creating welcoming classrooms.

This essay examines the Inclusive Teaching Circle (ITC) as a mechanism for faculty development in creating instructional tools that embrace an inclusive pedagogy reflecting diversity, cultural competence and social justice. We describe one group’s year-long participation in an ITC at a large, metropolitan research university in the south. Next, we share several members’ strategies for promoting more inclusive and equitable learning for students in our classrooms. Finally, we consider the implications of ITCs for its group participants and the professorate at large