47,912 research outputs found
Monomial Testing and Applications
In this paper, we devise two algorithms for the problem of testing
-monomials of degree in any multivariate polynomial represented by a
circuit, regardless of the primality of . One is an time
randomized algorithm. The other is an time deterministic
algorithm for the same -monomial testing problem but requiring the
polynomials to be represented by tree-like circuits. Several applications of
-monomial testing are also given, including a deterministic
upper bound for the -set -packing problem.Comment: 17 pages, 4 figures, submitted FAW-AAIM 2013. arXiv admin note:
substantial text overlap with arXiv:1302.5898; and text overlap with
arXiv:1007.2675, arXiv:1007.2678, arXiv:1007.2673 by other author
Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin.
While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known. Here, we studied the ovarian and reproductive phenotypes in an Fmr1 knockout (KO) mouse model and the role of mammalian target of rapamycin (mTOR) signaling. Breeding, histologic and mTOR signaling data were obtained at multiple time points in KO and wild type (WT) mice fed a control or rapamycin (mTOR inhibitor) diet. KO mice showed an earlier decline in ovarian reserve than WT mice with an increased proportion of activated follicles. mTOR and phosphorylated S6 kinase (p-S6K) levels, a measure of downstream mTOR signaling, were elevated in the KO ovaries. Rapamycin blocked these effects in KO mice, and increased the primordial follicle pool and age of last litter in WT mice. Our data demonstrates an early decline in reproductive capacity in Fmr1 KO mice and proposes that premature recruitment of the primordial pool via altered mTOR signaling may be the mechanism. Reversal of phenotypes and protein levels in rapamycin-treated KO mice, as well as increased reproductive lifespan of rapamycin-fed WT mice, suggest the mTOR pathway as a potential therapeutic target
Advancing Technology of Clinical Laboratory Practice
In spite of the temporary antitechnology attitude of a portion of our society, the future will be an era of automated technology. Buckminster Fuller has reviewed the progress of industrial technology and points out that continuing scientific advances are inevitable and that technical applications will provide more equitable distribution of wealth, more time, more opportunity for education and intellectual pursuits
Unique Characteristics and Implications of Individual Health Profiles
During the era of the prescientific medicine, people were divided into two categories: those who were sick and those who were not sick. Physicians found it necessary to establish criteria to differentiate the ill and separate them according to symptoms and signs characteristic of classifiable diseases. Because of preoccupation with disease, the concept of the normal versus the pathological, as two opposite and definable conditions, was inevitable in the absence of scientific knowledge of human chemistry and physiology. This concept has carried over into the present era of scientific medicine
Accounting Education: A Statistical Survey, 1982-83
https://egrove.olemiss.edu/aicpa_guides/2233/thumbnail.jp
Accounting Education: A Statistical Survey, 1992-93
https://egrove.olemiss.edu/aicpa_guides/2235/thumbnail.jp
Spatial and Temporal Modeling of Community Non-Timber Forest Extraction
This paper examines the interaction of spatial and dynamic aspects of resource extraction from forests by local people. Highly cyclical and varied across both space and time, the patterns of resource extraction resulting from the spatial-temporal model bear little resemblance to the patterns drawn from focusing either on spatial or temporal aspects of extraction, as is typical in both the modeling and empirical literature to date. Combining the spatial-temporal model with a measure of success in community forest management.the ability to avoid open-access resource degradation.characterizes the impact of incomplete property rights on patterns of resource extraction and stocks. Key words: Spatial and temporal modeling; renewable resources; non-timber forest products; common property resources
Accounting Education: A Statistical Survey, 1987-88
https://egrove.olemiss.edu/aicpa_guides/2234/thumbnail.jp
Uniform Statistical Information Questionnaire Data: A Supplementary Report
https://egrove.olemiss.edu/aicpa_exam/1223/thumbnail.jp
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