2,916 research outputs found

    The Actions and Feelings Questionnaire in Autism and Typically Developed Adults

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    Open access via Springer Compact Agreement We are grateful to Simon Baron-Cohen and Paula Smith of the Cambridge Autism Centre for the use of the ARC database in distributing the questionnaire, to all participants for completing it, to Eilidh Farquar for special efforts in distributing the link and to Gemma Matthews for advice on using AMOS 23. JHGW is supported by the Northwood Trust.Peer reviewedPublisher PD

    Action perception is intact in autism spectrum disorder

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    Date of Acceptance:10/11/2014. Copyright © 2015 the authors 0270-6474/15/351849-09$15.00/0. Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license.Peer reviewedPublisher PD

    What we know now : education, neuroscience and transdisciplinary autism research

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    The cerebellum plays more than one role in the dysregulation of appetite : Review of structural evidence from typical and eating disorder populations

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    ACKNOWLEDGMENTS I would like to extend my sincere gratitude to the Northwood Charitable Trust for funding my PhD studentship. Grant Number: RG15207Peer reviewedPublisher PD

    Emotional self-awareness in autism: A meta-analysis of group differences and developmental effects

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    Open Access via the Sage Open Access Agreement Acknowledgements We would like to sincerely thank all the authors who shared their data with us. Research data available upon request from first author (C.F.H.). Funding The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The authors thank the Northwood Trust for their financial support for this research.Peer reviewedPublisher PD

    Sex differences in the association of photoperiod with hippocampal subfield volumes in older adults : A crosssectional study in the UK Biobank cohort

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    © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.Peer reviewedPublisher PD

    Guided Neuronal Growth on Arrays of Biofunctionalized GaAs/InGaAs Semiconductor Microtubes

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    We demonstrate embedded growth of cortical mouse neurons in dense arrays of semiconductor microtubes. The microtubes, fabricated from a strained GaAs/InGaAs heterostructure, guide axon growth through them and enable electrical and optical probing of propagating action potentials. The coaxial nature of the microtubes -- similar to myelin -- is expected to enhance the signal transduction along the axon. We present a technique of suppressing arsenic toxicity and prove the success of this technique by overgrowing neuronal mouse cells.Comment: 3 pages, 4 figure

    DHA and EPA Interaction with Raft Domains Observed With Solid-State 2H NMR Spectroscopy

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    poster abstractResearch continues to examine the health benefits of omega-3 polyunsaturated fatty acids (n-3 PUFA) found in fish oils. The major bioactive components are eicosapentaenoic acid (EPA, 20:5), with 20 carbons and 5 double bonds, and docosahexaenoic acid (DHA, 22:6), with 22 carbons and 6 double bonds. However, their molecular modes of action remain unclear. A suggested hypothesis is that these fatty acids are incorporated into membrane phospholipids and modify the structure and organization of lipid rafts, thus affecting cell signaling. We used solid-state 2H NMR spectroscopy to compare molecular organization in mixtures of 1-palmitoyl-2-eicosapentaenoylphosphatidylcholine (PEPC) and 1-palmitoyl-2-docosahexaenoylphosphatidylcholine (PDPC) with the raft-stabilizing molecules sphingomyelin (SM) and cholesterol. Our spectra for PEPC-d31 and PDPC-d31, analogs of PEPC and PDPC with a perdeuterated palmitoyl sn-1 chain, showed that DHA has a greater tendency than EPA to incorporate into raft-like domains enriched in SM and cholesterol. By using PSM-d31, an analog of SM with a perdeuterated N-palmitoyl chain, we now directly observe one of the raft-forming molecules and analyze the molecular order within the raft. These results will add to the growing information on how EPA and DHA differentially modify lipid domain organization in bilayers
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