Pilot-testing a Cancer 101 Education Curriculum with the Fairbanks Native Association’s Women & Children’s Center for Inner Healing

Cancer is the leading cause of death among Alaska Native people Nevertheless, due to improved detection awareness about cancer prevention, early screening and advances in treatment survival rates are rising

Petrology and geochemistry of nakhlite MIL 03346: A new Martian meteorite from Antarctica

MIL 03346 is the first nakhlite in the US Antarctic collection. We have performed detailed mineralogical and bulk-geochemical investigations to compare petrogenesis of this Martian meteorite with other nakhlites

Carrier-controlled ferromagnetism in SrTiO3

Magnetotransport and superconducting properties are investigated for uniformly La-doped SrTiO3 films and GdTiO3/SrTiO3 heterostructures, respectively. GdTiO3/SrTiO3 interfaces exhibit a high-density two-dimensional electron gas on the SrTiO3-side of the interface, while for the SrTiO3 films carriers are provided by the dopant atoms. Both types of samples exhibit ferromagnetism at low temperatures, as evidenced by a hysteresis in the magnetoresistance. For the uniformly doped SrTiO3 films, the Curie temperature is found to increase with doping and to coexist with superconductivity for carrier concentrations on the high-density side of the superconducting dome. The Curie temperature of the GdTiO3/SrTiO3 heterostructures scales with the thickness of the SrTiO3 quantum well. The results are used to construct a stability diagram for the ferromagnetic and superconducting phases of SrTiO3.Comment: Revised version that is closer to the published version; Fig. 2 correcte

Class Numbers and Biquadratic Reciprocity

The research of the first author was supported by Natural Sciences and Engineering Research Council Canada Grant No. A-7233, while that of the second was supported by a Natural Sciences and Engineering Research Council Canada Undergraduate Summer Research Award.https://www.cambridge.org/core/journals/canadian-journal-of-mathematics/article/class-numbers-and-biquadratic-reciprocity/00FECEE10C8CB10943F2ED8E7AAE2B8

Improving the retention rate for residential treatment of substance abuse by sequential intervention for social anxiety

BACKGROUND Residential drug rehabilitation is often seen as a treatment of last resort for people with severe substance abuse issues. These clients present with more severe symptoms, and frequent psychiatric comorbidities relative to outpatients. Given the complex nature of this client group, a high proportion of clients seeking treatment often do not enter treatment, and of those who do, many exit prematurely. Given the highly social nature of residential drug rehabilitation services, it has been argued that social anxieties might decrease the likelihood of an individual entering treatment, or increase the likelihood of them prematurely exiting treatment. The current paper reports on the protocol of a Randomised Control Trial which examined whether treatment of social anxiety prior to entry to treatment improves entry rates and retention in residential drug rehabilitation. METHOD/DESIGN A Randomised Control Trial comparing a social skills treatment with a treatment as usual control group was employed. The social skills training program was based on the principles of Cognitive Behaviour Therapy, and was adapted from Ron Rapee's social skills training program. A permutated block randomisation procedure was utilised. Participants are followed up at the completion of the program (or baseline plus six weeks for controls) and at three months following entry into residential rehabilitation (or six months post-baseline for participants who do not enter treatment). DISCUSSION The current study could potentially have implications for addressing social anxiety within residential drug treatment services in order to improve entry and retention in treatment. The results might suggest that the use of additional screening tools in intake assessments, a focus on coping with social anxieties in support groups for clients waiting to enter treatment, and greater awareness of social anxiety issues is warranted. AUSTRALIAN NEW ZEALAND CLINICAL TRIALS REGISTRY Australian New Zealand Clinical Trials Registry (ACTRN) registration number: ACTRN12611000579998.This research was supported under Australian Research Council's Linkage Projects funding scheme (project number: LP0990162)

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease.

While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated. We used targeted adeno-associated viral vector (AAV) overexpression of human mutant α-synuclein (A53T) in the rat substantia nigra (SN) to produce degeneration of SN dopamine neurons, loss of striatal dopamine levels, and behavioral impairment. Some animals received daily GM1 ganglioside administration for 6 weeks, beginning 24 hours after AAV-A53T administration or delayed start GM1 administration for 5 weeks beginning 3 weeks after AAV-A53T administration. Both types of GM1 administration protected against loss of SN dopamine neurons and striatal dopamine levels, reduced α-synuclein aggregation, and delayed start administration of GM1 reversed early appearing behavioral deficits. These results extend prior positive results in MPTP models, are consistent with the results of a small clinical study of GM1 in PD patients that showed slowing of symptom progression with chronic use, and argue for the continued refinement and development of GM1 as a potential disease modifying therapy for PD

Annealing kinetics of nanoindentation-induced polycrystalline high pressure phases in crystalline silicon

Transformation kinetics of nanoindented zones in silicon containing high pressure crystalline phases (Si III and Si XII) during annealing (100 °C<T<450 °C) have been studied using Raman microspectroscopy and cross-sectional transmission electron microscopy. Signature peaks associated with Si III/XII in the Raman spectra were monitored to track the annealing of these phases to polycrystalline Si I as a function of annealing time and temperature. An overall activation energy for this transformation was found to be 0.67 eV. During annealing, Si XII disappeared faster than Si III, suggesting either that Si XII first converts to Si III or that Si XII transforms to polycrystalline Si I faster than Si III

Geographical location and stage of breast cancer diagnosis: A systematic review of the literature

Objective: To examine systematically the literature on the effect of geographical location variation on breast cancer stage at diagnosis, race/ethnicity, and socioeconomic status. Methods. Eight electronic databases were searched using combination of key words. Of the 312 articles retrieved from the search, 36 studies from 12 countries were considered eligible for inclusion. Results. This review identified 17 (47%) of 36 studies in which breast cancer patients residing in geographically remote/rural areas had more late-stage diagnosis than urban women. Ten (28%) studies reported higher proportions of women diagnosed with breast cancer resided in urban than rural counties. Nine (25%) studies reported no statistically significant association between place of residence and stage at diagnosis for breast cancer patients residing in rural and urban areas. Conclusions. Cancer patients residing in rural and disadvantaged areas were more likely to be diagnosed with distant breast metastasis. Efforts to reduce these inequalities and subsequent mortality are needed