Intellectual Property Rights and Innovation: Evidence from the Human Genome

Do intellectual property (IP) rights on existing technologies hinder subsequent innovation? Using newly-collected data on the sequencing of the human genome by the public Human Genome Project and the private rm Celera, this paper estimates the impact of Celera's gene-level IP on subsequent scienti c research and product development. Genes initially sequenced by Celera were held with IP for up to two years, but moved into the public domain once re-sequenced by the public e ort. Across a range of empirical speci cations, I nd evidence that Celera's IP led to reductions in subsequent scienti c research and product development on the order of 20 to 30 percent. Taken together, these results suggest that Celera's short-term IP had persistent negative e ects on subsequent innovation relative to a counterfactual of Celera genes having always been in the public domain

Intellectual Property Rights and Innovation: Evidence from the Human Genome

Do intellectual property (IP) rights on existing technologies hinder subsequent innovation? Using newly-collected data on the sequencing of the human genome by the public Human Genome Project and the private firm Celera, this paper estimates the impact of Celera's gene-level IP on subsequent scientific research and product development. Genes initially sequenced by Celera were held with IP for up to two years, but moved into the public domain once re-sequenced by the public effort. Across a range of empirical specifications, I find evidence that Celera's IP led to reductions in subsequent scientific research and product development on the order of 20 to 30 percent. Taken together, these results suggest that Celera's short-term IP had persistent negative effects on subsequent innovation relative to a counterfactual of Celera genes having always been in the public domain.

Do Firms Underinvest in Long-Term Research? Evidence from Cancer Clinical Trials

We investigate whether private research investments are distorted away from long-term projects. Our theoretical model highlights two potential sources of this distortion: short-termism and the fixed patent term. Our empirical context is cancer research, where clinical trials -- and hence, project durations -- are shorter for late-stage cancer treatments relative to early-stage treatments or cancer prevention. Using newly constructed data, we document several sources of evidence that together show private research investments are distorted away from long-term projects. The value of life-years at stake appears large. We analyze three potential policy responses: surrogate (non-mortality) clinical-trial endpoints, targeted R&D subsidies, and patent design

Sources of Geographic Variation in Health Care: Evidence From Patient Migration

We study the drivers of geographic variation in U.S. health care utilization, using an empirical strategy that exploits migration of Medicare patients to separate the role of demand and supply factors. Our approach allows us to account for demand differences driven by both observable and unobservable patient characteristics. Within our sample of over-65 Medicare beneficiaries, we find that 40–50% of geographic variation in utilization is attributable to demand-side factors, including health and preferences, with the remainder due to place-specific supply factors.National Institute on Aging (R01-AG032449)National Institute on Aging (P01-AG19783)National Science Foundation (U.S.) (Grant 1151497)National Science Foundation (U.S.) (Grant 1260411)Neubauer Family FoundationUniversity of Chicago. Booth School of Business (Initiative on Global Markets

Why Is Infant Mortality Higher in the United States than in Europe?

The United States has higher infant mortality than peer countries. In this paper, we combine microdata from the United States with similar data from four European countries to investigate this US infant mortality disadvantage. The US disadvantage persists after adjusting for potential differential reporting of births near the threshold of viability. While the importance of birth weight varies across comparison countries, relative to all comparison countries the United States has similar neonatal (<1 month) mortality but higher postneonatal (1–12 months) mortality. We document similar patterns across census divisions within the United States. The postneonatal mortality disadvantage is driven by poor birth outcomes among lower socioeconomic status individuals. (JEL I12, I14, I32, J14)National Institute on Aging (Grant Number T32-AG000186)National Science Foundation (U.S.) (Grant Number 1151497

Patents and Research Investments: Assessing the Empirical Evidence

A well-developed theoretical literature--dating back at least to Nordhaus (1969)--has analyzed optimal patent policy design. We re-present the core trade-off of the Nordhaus model and highlight an empirical question which emerges from the Nordhaus framework as a key input into optimal patent policy design: namely, what is the elasticity of R&D investment with respect to the patent term? We then review the--surprisingly small--body of empirical evidence that has been developed on this question over the nearly half century since the publication of Nordhaus's book.National Institute on AgingNational Institutes of Health (U.S.) (Common Fund, Office of the NIH Director, through grant U01-AG046708

Mexican American and European American Adolescents\u27 Dating Experiences across the Ecosystem: Implications for Healthy Relationships within an Ecodevelopmental Framework

Dating health interventions that target the complex, multi-systemic spheres in which adolescents experience their first romantic relationships are required. This study utilizes an ecodevelopmental approach to better understand Mexican American and European American youths\u27 perceptions of how peers, parents, school, and the media act both independently and collectively to affect their dating lives, also elucidating how such systems are at times in conflict. Seventy-five middle adolescents participated in focus groups divided by gender and ethnicity to uncover differences and similarities within and across groups. Findings underscore the importance and widespread effects of romantic relationships for adolescents\u27 social development and the need for intervention programs that target multiple points of intervention while attending to mesosystemic conflicts across systems

Trust, Cheating, and Dating Violence in Mexican American Adolescent Romantic Relationships

Many adolescents experience some aspect of cheating in their romantic relationships, yet developmental and cultural influences on this experience are not well understood. A grounded theory approach was used to uncover the processes through which cheating resulted in dating violence among 64 Mexican American adolescents (15 to 17 years old). Focus groups, separated by level of acculturation and gender (N = 20), revealed paradoxical expectations for trust and cheating in romantic relationships. Low acculturated youth, particularly males, held broader definitions of cheating behaviors, used peers to monitor cheating behaviors, and took breaches of cheating more seriously. Males were perceived as more likely to cheat, to cheat because of their diminished desire for commitment, and to use violence in reaction to cheating behavior. It is recommended that teen dating violence prevention programs use culturally attuned curricula that incorporate the integral role of peers and gendered norms and expectations within adolescents’ dating relationships

Help-seeking and help-offering for teen dating violence among acculturating Mexican American adolescents

Help-seeking sources, motivations, and barriers concerning teen dating violence are rarely co-examined alongside help-offering processes and messages, and both are understudied among minority youth populations. This study sought the perspectives of Mexican American adolescents (ages 15 to 17) concerning their preferences and experiences with both help-seeking and help-offering. Twenty focus groups (N = 64 adolescents) were divided by gender and by acculturation level to allow for group comparisons. Friends and supportive family members were primary sources of help, although adolescents voiced a number of barriers to help-seeking. The most prominent barrier was fear they would be told to leave the relationship, an anticipated message that aligned with their tendency to tell others to do so. Help-seeking was viewed as a weakness, and help-offering was reserved for friends that asked for it. Recommendations for programs and practice with youth include promoting culturally and gender attuned teen dating violence services that emphasize confidentiality, and working at the family, peer, and school levels to foster healthy relationships

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of synthetic drugs. An increasingly investigated approach is the use of bioactive forages with antiparasitic properties as part of the animal’s diet (nutraceuticals) or as potential sources of novel, natural parasiticides. Chicory (Cichorium intybus) is a multi-purpose crop and one of the most promising bioactive forages in temperate regions, and numerous in vivo trials have explored its potential against parasitic nematodes in livestock. However, it is unclear whether chicory can induce a direct and broad activity against various GI parasites in different livestock species, and the levels of chicory in the diet that are required to exert an efficient antiparasitic effect. Moreover, the mechanisms leading to the reported parasiticidal activity of chicory are still largely unknown, and its bioactive phytochemicals have only recently been investigated. In this review, we summarise the progress in the study of the antiparasitic activity of chicory and its natural bioactive compounds against GI parasites in livestock, through examination of the published literature. The available evidence indicates that feeding chicory can reduce faecal egg counts and/or worm burdens of abomasal nematodes, but not infections with intestinal worms, in ruminants. Highly chicory-rich diets (≥ 70% of chicory dry matter in the diet) may be necessary to directly affect abomasal parasitism. Chicory is known to synthesise several bioactive compounds with potential antiparasitic activity, but most research has been devoted to the role of sesquiterpene lactones (SL). Recent in vitro studies have confirmed direct and potent activity of SL-rich extracts from chicory against different GI helminths of livestock. Chicory SL have also been reported to exhibit antimalarial properties and its potential antiprotozoal activity in livestock remains to be evaluated. Furthermore, the detailed identification of the main antiparasitic metabolites of chicory and their pharmacokinetics need further confirmation. Research gaps and perspectives on the potential use of chicory as a nutraceutical forage and a source of bioactive compounds for parasite control in livestock are discussed