Host‐Response Therapeutics for Periodontal Diseases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141161/1/jper1592.pd

Periodontal Surveillance – Prospects for the Future

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141014/1/jper1365.pd

Periodontal Surveillance – Implications in the Promotion of Public Health

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142113/1/jper1177.pd

Enhancing Periodontal Health Through Regenerative Approaches

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142301/1/jpers1.pd

Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141896/1/jper0556.pd

Gene therapy for periodontal bioengineering

Although significant advancements have been achieved in periodontal therapy over the last decade, predictable regeneration of the tooth-supporting tissues is a challenge in periodontology and oral implantology. Recently, gene therapy, a new therapeutic approach for genetic and acquired diseases, has been applied for tissue bioengineering in multiple clinical situations, including the craniofacial complex, among them defects resulting from periodontal disease. The use of gene therapy vectors has enhanced the bioavailability and targeting of multiple growth and host immune factors to repair alveolar bone defects. Early pre-clinical studies utilizing both ex vivo and in vivo gene transfer strategies demonstrate the feasibility of using gene therapy for periodontal tissue engineering. This review highlights the current progress made in the field of periodontal regenerative medicine via gene targeting approaches

When epigenetics meets bioengineering—A material characteristics and surface topography perspective

The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2065–2071, 2018.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144628/1/jbmb33953.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144628/2/jbmb33953_am.pd

Erratum: Functional apparent moduli as predictors of oral implant osseointegration dynamics

No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78226/1/31720_ftp.pd

Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and metaâ analysis

AimsTo study the effect of the recombinant human bone morphogenetic protein 2 (rhBMPâ 2) on sinus volumetric and histometric changes after sinus floor augmentation compared to a conventional approach of nonâ biologic bone grafting materials.Materials and methodsAn electronic search of 4 databases (January 1990â February 2015), including PubMed/MEDLINE, EMBASE, Web of Science and Cochrane Central, and a hand search of peerâ reviewed journals for relevant articles were performed. Human clinical trials with data on comparison of sinus volumetric and/or histometric outcomes with and without the use of rhBMPâ 2 in sinus grafting procedures, with â ¥10 augmentation sites in each study group, and with a followâ up period of at least 6 months, were included. Randomâ effects metaâ analyses were performed to analyze weighted mean difference (WMD) and confidence interval (CI) for the recorded variables according to PRISMA guidelines.ResultsSix randomized controlled trials (RCTs) were included. The results of the metaâ analyses showed that the WMD of vertical bone height gain was â 0.14 mm (95% CI = â 1.91 to 1.62 mm, P = 0.87), the WMD of bone density was â 142.42 mg/cm3 (95% CI = â 310.62â 25.78 mg/cm3, P = 0.10), the WMD of the percentage of vital bone was â 4.59% (95% CI = â 11.73â 2.56%, P = 0.21), and the WMD of the percentage of residual bone grafting materials was â 9.90% (95% CI = â 26.38â 6.58%, P = 0.21). The comparison of implant survival rate presented an overall risk ratio of 1.00 (95% CI = 0.94â 1.07). The two approaches (conventional bone grafting compared to BMPs) demonstrated comparable effectiveness for both clinical and histomorphometric measures.ConclusionsThis systematic review revealed that the use of rhBMPâ 2 in maxillary sinus floor augmentation achieved similar clinical and histometric outcomes when compared to conventional sinus grafting procedures after a healing period of 6â 9 months. However, previous studies showed the morbidity and other patientâ reported outcomes were improved in rhBMPâ 2 approaches as compared to bone autograft procedures (both intraoral and extraoral bone harvesting because no donor site is required). Longâ term studies are required to determine the costâ benefit of sinus floor augmentation procedures for patients requiring implant reconstruction.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134457/1/clr12737.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134457/2/clr12737_am.pd

Wound healing dynamics, morbidity, and complications of palatal soft-tissue harvesting

Palatal-tissue harvesting is a routinely performed procedure in periodontal and peri-implant plastic surgery. Over the years, several surgical approaches have been attempted with the aim of obtaining autogenous soft-tissue grafts while minimizing patient morbidity, which is considered the most common drawback of palatal harvesting. At the same time, treatment errors during the procedure may increase not only postoperative discomfort or pain but also the risk of developing other complications, such as injury to the greater palatine artery, prolonged bleeding, wound/flap sloughing, necrosis, infection, and inadequate graft size or quality. This chapter described treatment errors and complications of palatal harvesting techniques, together with approaches for reducing patient morbidity and accelerating donor site wound healing. The role of biologic agents, photobiomodulation therapy, local and systemic factors, and genes implicated in palatal wound healing are also discussed