A critical evaluation of the Down syndrome diagnosis for LB1, type specimen of Homo floresiensis

The Liang Bua hominins from Flores, Indonesia, have been the subject of intense scrutiny and debate since their initial description and classification in 2004. These remains have been assigned to a new species, Homo floresiensis, with the partial skeleton LB1 as the type specimen. The Liang Bua hominins are notable for their short stature, small endocranial volume, and many features that appear phylogenetically primitive relative to modern humans, despite their late Pleistocene age. Recently, some workers suggested that the remains represent members of a small-bodied island population of modern Austro-Melanesian humans, with LB1 exhibiting clinical signs of Down syndrome. Many classic Down syndrome signs are soft tissue features that could not be assessed in skeletal remains. Moreover, a definitive diagnosis of Down syndrome can only be made by genetic analysis as the phenotypes associated with Down syndrome are variable. Most features that contribute to the Down syndrome phenotype are not restricted to Down syndrome but are seen in other chromosomal disorders and in the general population. Nevertheless, we re-evaluated the presence of those phenotypic features used to support this classification by comparing LB1 to samples of modern humans diagnosed with Down syndrome and euploid modern humans using comparative morphometric analyses. We present new data regarding neurocranial, brain, and symphyseal shape in Down syndrome, additional estimates of stature for LB1, and analyses of inter- and intralimb proportions. The presence of cranial sinuses is addressed using CT images of LB1. We found minimal congruence between the LB1 phenotype and clinical descriptions of Down syndrome. We present important differences between the phenotypes of LB1 and individuals with Down syndrome, and quantitative data that characterize LB1 as an outlier compared with Down syndrome and non-Down syndrome groups. Homo floresiensis remains a phenotypically unique, valid species with its roots in Plio-Pleistocene Homo taxa

Accounting Hall of Fame induction: Charles Arthur Bowsher; Accounting Hall of Fame induction: Donald James Kirk; Accounting Hall of Fame induction: William Henry Beaver

For Charles Arthur Bowsher\u27s induction, the Citation was written by Daniel L. Jensen, Professor , The Ohio State University and read by Arhtur R. Wyatt, professor, University of Illinois and a Rseponse was made by Charles A. Bowsher. For Donald James Kirk\u27s induction, Remarks were made by Paul Kolton, the Citation written by Daniel L. Jensen, Professor, Fisher College of Business, The Ohio State University and read by Paul Kolton, Stamford, Connecticut and a Response made by Donald James Kirk. For the induction of William Henry Beaver, the Remarks were made by Charles T. Horngren, Professor, Stanford University, Hall of Fame Member and the Citation was written by Daniel L. Jensen, Professor, The Ohio State University and read by Charles T. Horngren, Professor, Stanford University, Hall of Fame member and a Response was made by William H. Beaver

Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography study

Prior efforts to image cholinergic projections in human brain in vivo had significant technical limitations. We used the vesicular acetylcholine transporter (VAChT) ligand [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) and positron emission tomography to determine the regional distribution of VAChT binding sites in normal human brain. We studied 29 subjects (mean age 47 [range 20–81] years; 18 men; 11 women). [18F]FEOBV binding was highest in striatum, intermediate in the amygdala, hippocampal formation, thalamus, rostral brainstem, some cerebellar regions, and lower in other regions. Neocortical [18F]FEOBV binding was inhomogeneous with relatively high binding in insula, BA24, BA25, BA27, BA28, BA34, BA35, pericentral cortex, and lowest in BA17–19. Thalamic [18F]FEOBV binding was inhomogeneous with greatest binding in the lateral geniculate nuclei and relatively high binding in medial and posterior thalamus. Cerebellar cortical [18F]FEOBV binding was high in vermis and flocculus, and lower in the lateral cortices. Brainstem [18F]FEOBV binding was most prominent at the mesopontine junction, likely associated with the pedunculopontine–laterodorsal tegmental complex. Significant [18F]FEOBV binding was present throughout the brainstem. Some regions, including the striatum, primary sensorimotor cortex, and anterior cingulate cortex exhibited age‐related decreases in [18F]FEOBV binding. These results are consistent with prior studies of cholinergic projections in other species and prior postmortem human studies. There is a distinctive pattern of human neocortical VChAT expression. The patterns of thalamic and cerebellar cortical cholinergic terminal distribution are likely unique to humans. Normal aging is associated with regionally specific reductions in [18F]FEOBV binding in some cortical regions and the striatum.Using [18F]FEOBV PET, we describe the distribution of cholinergic terminals in human brain. The distribution of cholinergic terminals is similar to that found in other mammals with some distinctive features in cortex, thalamus, and cerebellum. There are regionally specific age‐related changes in cholinergic terminal density.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146604/1/cne24541.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146604/2/cne24541_am.pd

Measuring M2 values for on-wafer vertical cavity surface emitting lasers

We report on M2 measurements taken for on-wafer vertical cavity surface emitting lasers (VCSELs). We measured M2 for oxide-confined VCSELs and photonic crystal (PhC) VCSELs of similar lasing aperture sizes

Earthquake science in resilient societies

Earthquake science is critical in reducing vulnerability to a broad range of seismic hazards. Evidenceâ based studies drawing from several branches of the Earth sciences and engineering can effectively mitigate losses experienced in earthquakes. Societies that invest in this research have lower fatality rates in earthquakes and can recover more rapidly. This commentary explores the scientific pathways through which earthquakeâ resilient societies are developed. We highlight recent case studies of evidenceâ based decision making and how modern research is improving the way societies respond to earthquakes.Key PointsThe level of seismic risk depends in part on societal investment in earthquake scienceMultidisciplinary investigations involving earthquake scientists and engineers greatly reduce casualties in earthquakesRecent examples highlight the utility of earthquake science in building resilient societies and the need for further research to reduce seismic riskPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137197/1/tect20552_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137197/2/tect20552.pd

Cholinergic system changes of falls and freezing of gait in Parkinson’s disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149240/1/ana25430_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149240/2/ana25430.pd

Characterization of Single-Mode Vertical Cavity Surface-Emitting Lasers

A high-quality single-mode beam is desirable for the efficient use of lasers as light sources for optical data communications and interconnects, however there is little data which characterizes operating ranges and near-field beam qualities of Vertical Cavity Surface Emitting Lasers (VCSELs), which has resulted in a lack of analysis of these devices. Measures of beam quality include beam-quality factor (M2 ), Side-Mode-Suppression-Ratio (SMSR) and RMS linewidth. M2 is a measurement of how closely the beam is to an ideal Gaussian. SMSR is the difference, in dB, between the amplitude of the primary peak and the amplitude of the next highest peak of the output spectrum, with single-mode operation defined by a SMSR \u3e 30 dB. RMS linewidth is a second moment calculation involving the power spectral density, where smaller RMS linewidth indicates higher beam quality. Utilizing a novel vertical M2 setup in which on-wafer VCSEL M2 can be measured, a study was conducted on the relation between M2 , SMSR and RMS linewidth, for various oxide-confined VCSELs of varying aperture sizes and Photonic Crystal (PhC) VCSELs of varying aperture sizes and photonic crystal configurations. First, the operating range of the VCSEL was determined utilizing a Semiconductor Parameter Analyzer to obtain the LIV characteristics. Along with this measurement, spectral data was collected using an Optical Spectrum Analyzer at several key operating points, which allowed the RMS linewidths and SMSRs of the devices to be calculated at these points. The novel beam-profiler setup was used to measure the device’s M2 . Initial results show a strong correlation between the measures of beam quality, with increasing SMSR, corresponding to M2 values closer to 1, and single-mode operation characterized by a M2 of less than 1.5. A strong correlation between RMS linewidth and M2 was also seen, with increasing RMS linewidths corresponding to an increase in M2

Characterization of Single-Mode Vertical Cavity Surface-Emitting Lasers

A high-quality single-mode beam is desirable for the efficient use of lasers as light sources for optical data communications and interconnects, however there is little data which characterizes operating ranges and near-field beam qualities of Vertical Cavity Surface Emitting Lasers (VCSELs), which has resulted in a lack of analysis of these devices. Measures of beam quality include beam-quality factor (M2 ), Side-Mode-Suppression-Ratio (SMSR) and RMS linewidth. M2 is a measurement of how closely the beam is to an ideal Gaussian. SMSR is the difference, in dB, between the amplitude of the primary peak and the amplitude of the next highest peak of the output spectrum, with single-mode operation defined by a SMSR \u3e 30 dB. RMS linewidth is a second moment calculation involving the power spectral density, where smaller RMS linewidth indicates higher beam quality. Utilizing a novel vertical M2 setup in which on-wafer VCSEL M2 can be measured, a study was conducted on the relation between M2 , SMSR and RMS linewidth, for various oxide-confined VCSELs of varying aperture sizes and Photonic Crystal (PhC) VCSELs of varying aperture sizes and photonic crystal configurations. First, the operating range of the VCSEL was determined utilizing a Semiconductor Parameter Analyzer to obtain the LIV characteristics. Along with this measurement, spectral data was collected using an Optical Spectrum Analyzer at several key operating points, which allowed the RMS linewidths and SMSRs of the devices to be calculated at these points. The novel beam-profiler setup was used to measure the device’s M2 . Initial results show a strong correlation between the measures of beam quality, with increasing SMSR, corresponding to M2 values closer to 1, and single-mode operation characterized by a M2 of less than 1.5. A strong correlation between RMS linewidth and M2 was also seen, with increasing RMS linewidths corresponding to an increase in M2