Brief Sketches of the Early History of Lawrence University

William Harkness Sampson (1808-1902) was Principal and the primary financial agent of Lawrence University from the beginning of classes in 1849 until1853, during the time that the institution operated only as a preparatory school. He came to the Wisconsin Territory in 1842, where he worked as a Methodist minister. He was named Presiding Elder of the Green Bay Mission District in 1844. While serving in this position, he was approached by Amos Lawrence’s agents and became involved in the founding of Lawrence Institute. Following his resignation as principal and agent in 1853, he was a faculty member for several years longer and served on the Board of Trustees until 1884. The date of his written account of the early history of Lawrence is unknown.https://lux.lawrence.edu/archives_selections/1003/thumbnail.jp

Increasing doses of fiber do not influence short-term satiety or food intake and are inconsistently linked to gut hormone levels

Background: People who eat more fiber often have a lower body weight than people who eat less fiber. The mechanism for this relationship has been explained, in part, by increased satiety, which may occur as a result of changes in appetite-suppressing gut hormone levels, and decreases in food intake at subsequent meals. Objective: We hypothesized that increasing doses of mixed fiber, consumed in muffins for breakfast, would proportionally influence satiety, gut hormone levels, and subsequent food intake. Design: This was a randomized, double-blind, crossover study. Healthy men (n=10) and women (n=10) with a BMI of 24±2 (mean±SEM) participated in this study. Fasting subjects consumed a muffin with 0, 4, 8, or 12 g of mixed fibers and approximately 500 kcal. Visual analog scales rated hunger and satiety for 3 h; blood was drawn to measure ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY3–36 (PYY3–36) at various intervals; and food intake was measured at an ad libitum lunch. Results: Responses to satiety-related questions did not differ among treatments. However, despite lack of differences in satiety, gut hormone levels differed among treatments. Ghrelin was higher after the 12 g fiber dose than after the 4 and 8 g fiber doses. GLP-1 was higher after the 0 g fiber dose than after the 12 and 4 g fiber doses, and PYY3–36 did not differ among fiber doses. Food intake was also indistinguishable among doses. Conclusion: Satiety, gut hormone response, and food intake did not change in a dose-dependent manner after subjects consumed 0, 4, 8, and 12 g of mixed fiber in muffins for breakfast

A COST-EFFECTIVE MODEL FOR TEACHING ELEMENTARY STATISTICS WITH IMPROVED STUDENT PERFORMANCE

Dissatisfaction with teaching a high enrollment introductory statistics course led to efforts to restructure the course to remedy the perceived problems, including lack of student participation, an excessive drain on departmental resources, failure to take into account wide differences in student learning styles, an inability of students to apply statistics after the course, and negative attitudes of students. A cost-effective redesign of the course was implemented that incorporates a learning environment that is student-oriented, involves active student participation and hands-on experience with data analysis, uses technology to reduce costs through labor-saving techniques including low-stakes computerized testing, and sharing of resources enabled by a web site for course management and delivery of course materials. Responsibility for learning basic concepts was transferred to students and motivated by readiness assessment quizzes. The redesign led to about $125,000 in cost savings to the department

'Magic coins' and 'magic squares': the discovery of astrological sigils in the Oldenburg Letters

Enclosed in a 1673 letter to Henry Oldenburg were two drawings of a series of astrological sigils, coins and amulets from the collection of Strasbourg mathematician Julius Reichelt (1637–1719). As portrayals of particular medieval and early modern sigils are relatively rare, this paper will analyse the role of these medals in medieval and early modern medicine, the logic behind their perceived efficacy, and their significance in early modern astrological and cabalistic practice. I shall also demonstrate their change in status in the late seventeenth century from potent magical healing amulets tied to the mysteries of the heavens to objects kept in a cabinet for curiosos. The evolving perception of the purpose of sigils mirrored changing early modern beliefs in the occult influences of the heavens upon the body and the natural world, as well as the growing interests among virtuosi in collecting, numismatics and antiquities

Relationship between myocardial perfusion and function following coronary reflow in the canine heart using single photon emission computed tomography and two-dimensional echocardiography

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25660/1/0000212.pd

Gene Panel Testing for Breast Cancer Reveals Differential Effect of Prior BRCA1/2 Probability

From MDPI via Jisc Publications RouterHistory: accepted 2021-08-16, pub-electronic 2021-08-18Publication status: PublishedFunder: Manchester Biomedical Research Centre; Grant(s): IS-BRC-1215-20007Funder: Prevent breast cancer; Grant(s): GA19-002Whilst panel testing of an extended group of genes including BRCA1/2 is commonplace, these studies have not been subdivided by histiotype or by a priori BRCA1/2 probability. Patients with a breast cancer diagnosis undergoing extended panel testing were assessed for frequency of actionable variants in breast cancer genes other than BRCA1/2 by histiotype and Manchester score (MS) to reflect a priori BRCA1/2 likelihood. Rates were adjusted by prior testing for BRCA1/2 in an extended series. 95/1398 (6.3%) who underwent panel testing were found to be positive for actionable non-BRCA1/2 breast/ovarian cancer genes (ATM, BARD1, CDH1, CHEK2, PALB2, PTEN, RAD51C, RAD51D, TP53). As expected, PALB2, CHEK2 and ATM were predominant with 80-(5.3%). The highest rate occurred in Grade-3 ER+/HER2− breast cancers-(9.6%). Rates of non-BRCA actionable genes was fairly constant over all likelihoods of BRCA1/2 but adjusted rates were three times higher with MS 9 (BRCA1/2 = 1.5%, other = 4.7%), but was only 1.6% compared to 79.3% with MS ≥ 40. Although rates of detection of non-BRCA actionable genes are relatively constant across BRCA1/2 likelihoods this disguises an overall adjusted low frequency in high-likelihood families which have been heavily pre-tested for BRCA1/2. Any loss of detection sensitivity for BRCA1/2 actionable variants in breast cancer panels should lead to bespoke BRCA1/2 testing being conducted first