Exercise epigenetics and the foetal origins of disease

Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age). Evidence is accumulating [1] that exercise can acutely modify the epigenome (e.g., via DNA methylation) for short-term regulatory purposes (e.g., mRNA expression). More speculatively perhaps, maternal exercise during the pre and post–partum period could cause epigenetic changes in offspring. It is generally believed that there are benefits of regular moderate exercise during pregnancy [2]. The phenotypic benefits of maternal exercise notwithstanding, exercise can be viewed as a type of organismal stressor [1]. There are a myriad of ways in which environmental perturbations can affect foetal development. For example gestational stress could alter the epigenome and subsequent physical development. We suggest that maternal exercise -- like most gestational stressors -- will have a dose-response relationship on an offspring’s epigenome (i.e., negative effects at high doses), akin to the phenomenon of hormesis. Interestingly there is no research investigating the epigenetic effects of maternal exercise in humans. This editorial is a call for research on the subject

Siphonaptera Records and Host Associations From the Central and Eastern Upper Peninsula of Michigan

Fleas were collected from birds and mammals over a five year period in four upper peninsula counties. Identified specimens were compared to published records of distribution for the parasite species and its host species, and only those records which are new county distributions for host or parasite are listed. Four new host records for Michigan, four new flea distribution records for the upper peninsula, and 26 new county records are listed

An 8-DPSK TCM modem for MSAT-X

This paper describes the real-time digital implementation of an 8-differentiated phase-shift keying (DPSK) trellis-coded modulation (TCM) modem for operation on an L-band, 5 kHz wide, land mobile satellite (LMS) channel. The modem architecture as well as some of the signal processing techniques employed in the modem to combat the LMS channel impairments are described, and the modem performance over the fading channel is presented

Bar-holding prosthetic limb

A prosthetic device for below-the-elbow amputees is disclosed. The device has a removable effector, which is attached to the end of an arm cuff. The effector is comprised of a pair of C-shaped members that are oriented so as to face each other. Working in concert, the C-shaped members are able to hold a bar such as a chainsaw handle. A flat spring is fitted around the C-shaped members to hold them together

Rotationally actuated prosthetic helping hand

A prosthetic device has been developed for below-the-elbow amputees. The device consists of a cuff, a stem, a housing, two hook-like fingers, an elastic band for holding the fingers together, and a brace. The fingers are pivotally mounted on a housing that is secured to the amputee's upper arm with the brace. The stem, which also contains a cam, is rotationally mounted within the housing and is secured to the cuff, which fits over the amputee's stump. By rotating the cammed stem between the fingers with the lower arm, the amputee can open and close the fingers

Rival bishops, rival cathedrals : the election of Cormac, archdeacon of Sodor, as bishop in 1331

Peer reviewedPublisher PD

Rebalancing Bracker Forty Years Later

This Article examines forty years of federal and state courts’ application of the Bracker balancing test, which considers whether a state tax is preempted when assessed against a non-Indian on tribal land. First, this Article chronicles the history and progression of the Bracker balancing test in the Supreme Court. Second, this Article cross-tabulates judicial findings of no preemption with key characteristics of all lower court state taxation decisions that cite Bracker. Third, this Article reports the results of regression analyses that reveal lower courts were less likely to find preemption of cigarette taxes, more likely to find state fuel taxes were preempted, and that other key case characteristics were not significantly associated with preemption. Fourth, this Article identifies the inconsistent outcomes generated by lower courts in their application of the Bracker balancing test. Fifth, this Article presents ways in which the judiciary can revise and clarify the Bracker balancing test, in the hope of providing greater predictability and producing uniformity in the lower courts