Hypersensitivity Pneumonitis Associated with Environmental Mycobacteria-1

<p><b>Copyright information:</b></p><p>Taken from "Hypersensitivity Pneumonitis Associated with Environmental Mycobacteria"</p><p>Environmental Health Perspectives 2005;113(6):767-770.</p><p>Published online 10 Feb 2005</p><p>PMCID:PMC1257604.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Hypersensitivity Pneumonitis Associated with Environmental Mycobacteria-2

<p><b>Copyright information:</b></p><p>Taken from "Hypersensitivity Pneumonitis Associated with Environmental Mycobacteria"</p><p>Environmental Health Perspectives 2005;113(6):767-770.</p><p>Published online 10 Feb 2005</p><p>PMCID:PMC1257604.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Hypersensitivity Pneumonitis Associated with Environmental Mycobacteria-0

<p><b>Copyright information:</b></p><p>Taken from "Hypersensitivity Pneumonitis Associated with Environmental Mycobacteria"</p><p>Environmental Health Perspectives 2005;113(6):767-770.</p><p>Published online 10 Feb 2005</p><p>PMCID:PMC1257604.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

Cognitive similarities and differences between WBS patient cohorts and atypical partial deletion cases.

<p>Graphs showing the performance of WBS patients in Groups 1 or 2 (∼1.5/1.6 Mb or 1.8 Mb deletion respectively), patients with atypical deletions, and MA matched and CA matched controls. Differences occur between WBS patient subgroups on spatial perception. Atypical patients show impairments on emotion recognition and spatial perception relative to controls. Error bars represent standard error; * = significant difference at p<.01, ^○ = marginal difference at p<.05.</p

Cognitive similarities and differences between WBS patient cohorts and atypical partial deletion cases.

<p>Performance of WBS patients in Groups 1 or 2 (∼1.5/1.6 Mb or 1.8 Mb deletion respectively), patients with atypical deletions, and MA matched and CA matched controls. Differences are seen between WBS patient subgroups on cognitive flexibility. Atypical patients also show impairments on cognitive flexibility relative to controls. Error bars represent standard error; * = significant difference at p<.01, ^○ = marginal difference at p<.05.</p

Descriptive statistics for the WBS patient cohorts and for the atypical partial deletion cases (WBS425 and WBS023I).

<p><i>Note</i>: Mean (standard deviation) and range are reported for chronological age, IQ, and Socio-Economic Status. Chronological age and mental age are in years. Mean (standard deviation) are provided for WJ-R COG Factor Scores. Standard scores are represented. Standard scores have a mean of 100 and a standard deviation of 15. Scores below 80 are impaired compared to typically developing chronological age matched controls.</p

Williams-Beuren syndrome region on chromosome 7q11.23.

<p>Black lines represent the regions deleted in WBS patients. A: common ∼1.5/1.6 Mb deletion; B: ∼1.8 Mb deletion; C: patient WBS245; D: patient WBS023I; E: partial deletion patients with only isolated SVAS and associated cardiac pathologies<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047457#pone.0047457-Tassabehji1" target="_blank">[22]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047457#pone.0047457-Tassabehji2" target="_blank">[23]</a>. Shaded boxes represent the B-block flanking duplicons containing the deletion breakpoints (Bc = centromeric; Bm = medial; Bt = telomeric). Not to scale.</p

Clinical and genetic profile of WBS patient cohorts.

<p><b><i>Key:</i></b> +ve = deleted for ELN/LIMK1 FISH probe; −ve = not deleted for ELN/LIMK1 FISH probe. Bc refers to the centromeric breakpoint and Bm to the medial breakpoint.</p>#<p>approximate size due to the breakpoints residing in LCR duplicon regions. FD = facial dysmorphology; C = cardiac abnormality; SS = short stature; Hca = hypercalcaemia; HA = Hyperacusis; HS = hypersociability; Anx = Anxiety; Fear = Fears or Phobias; DD = developmental delay.</p