Annual growth rate and growth rate difference

*<p>Same cohort study</p>†<p>Data provided directly by the authors</p>‡<p>p value<0.05</p><p>NR Not reported</p

Figure 1

<p>Flow chart</p

Quality indicators for Cohort studies

*<p>Same results for Wilmink 2002 Beta blockers, Ca channel blockers, diuretics and ACE inhibitors studies</p

Other quality indicators for RCTs

*<p>Data provided directly by the authors</p

Description of included studies

*<p>Without precision</p>†<p>Same cohort study</p>‡<p>Data provided directly by the authors</p><p>NR Not reported</p

Figure 2

<p>Panel A–D. Forrest plot of growth rate difference in mm/year between intervention and control group</p

Time to Revascularization Curves (N = 3,448): Unadjusted (PANEL A) and Adjusted (PANEL B).

<p>Time to Revascularization Curves (N = 3,448): Unadjusted (PANEL A) and Adjusted (PANEL B).</p

Jadad's score and quality indicators for RCTs

*<p>Single blinded</p>†<p>Data provided directly by the authors</p

Hazard Ratios for CABG^* and PCI^** within one year by SUD^† (N = 3,448).

*<p><b><i>Coronary Artery Bypass Grafting.</i></b></p>**<p><b><i>Percutaneous Coronary Intervention.</i></b></p>†<p><b><i>Substance Use Disorder Defined By Consensus as In Methods.</i></b></p>‡<p><b><i>Hazard Ratio.</i></b></p>††<p><b><i>Adjusted For Age, Sex, APPROACH Comorbidities, Smoking and Severity of CAD.</i></b></p

Odds Ratios for in-hospital mortality and catheterization by SUD^* status (N = 7,876).

*<p><b><i>Substance Use Disorder Defined By Diagnostic Codes As Described In The Methods.</i></b></p>**<p><b><i>Odds Ratio for Those with SUD Compared To Those Without.</i></b></p>†<p><b><i>Adjusted For Age And Sex, Tu Comorbidities (See </i></b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066551#s2" target="_blank"><b><i>Methods</i></b></a><b><i>).</i></b></p>‡<p><b><i>Adjusted For Age, Sex, Elixhauser Comorbidities (See </i></b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066551#s2" target="_blank"><b><i>Methods</i></b></a><b><i>), Shock, Edema and Smoking.</i></b></p