504 research outputs found

    Chronic inflammatory neuropathies and their impact on activities and participation

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    Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are inflammatory neuropathies that can lead to considerable limitations in daily activities and in social participation. However, systematic evaluation of these self-reported limitations is lacking in the currently available studies. Understanding the impact of these diagnoses on patients' life is important to optimize management strategies.Aim: To systematically assess the self-reported limitations in activities and participation and determine associated factors.Methods: A survey study was conducted in 2021 in a cohort of patients with CIDP (n = 257) and MMN (n = 148) from a university hospital. The survey included the Rasch-built Overall Disability Scale and the Utrecht Scale for Evaluation of Rehabilitation-Participation, questions addressing personal and disease-related factors and treatment. Multivariate linear regression analysis was used to determine associations with disease-related and personal factors.Results: A total of 147 CIDP and 103 MMN patients responded. Limitations in activities were reported by 70.7% CIDP and 52.2% MMN patients with moderate to severe limitations in 22.4% and 5.9% patients, respectively. Participation restrictions were reported by 50% of CIDP and 40% of MMN patients, nevertheless satisfaction with participation was high. Fatigue, pain and resilience were independently associated with limitations in activities and satisfaction with participation in CIDP patients.Conclusions: Activity limitations and restrictions in participation are common in CIDP patients and to a lesser extent in MMN patients. Fatigue, pain and resilience independently contributed to perceived limitations in CIDP patients. Referral to a rehabilitation physician is warranted to address these limitations appropriately.</p

    ПРОУЧВАНЕ НА ХИМИЧНАТА НЕЕДНОРОДНОСТ НА КАДМИЙ И ОЛОВО В БИОСФЕРАТА - БИОАКУМУЛАЦИЯ НА КАДМИЙ И ОЛОВО В ОРГАНИЗМА НА МЛАДИ ПРЕЖИВНИ ЖИВОТНИ ОТ АНТРОПОГЕННИ ЕКОСИСТЕМИ С ПОВИШЕН ТЕХНОГЕНЕН КЛАРК

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    The technogenic Clarc of lead (Pb) and cadmium (Cd) from the upper soil layer and the forage plants in an industrially polluted region, so as the Pb and Cd input in the organism of young lambs and kid by the synthesis of secondary biological production have been investigated. For the synthesis of 1 kg secondary production in the organism of lambs, the input of Pb with the food and drinking water is 6.44 mg and 2.46 mg Cd and in the kid- organism- 21.41 mg Pb and 5.29 mg Cd. The obtained production in conditions of increased technogenic Clarc is with higher content of Pb and Cd, according the maximal admissible levels (EC- regulation 466/2001).Изследвани са технологичният кларк на олово и кадмий в горе н слой на почва и фуражи в индустриално замърсен район, както и постъпленията на олово и кадмий в организма на млади агнета и ярета при синтеза на вторична биологична продукция. За синтеза на 1 kg вторична продукция при агнета, постъпленията от фуража и питейната вода са 6,44 mg олово и 2,46 mg кадмий а в организма на яретата – съответно 21,41 mg олово и 5,29 mg кадмий. Получената в условията на повишен техногенен кларк продукция е с по високо съдържание на олово и кадмий спрямо пределнодопустимите концинтрации (EC regulation 466/2001)

    ПРОУЧВАНЕ НА ХИМИЧНАТА НЕЕДНОРОДНОСТ НА КАДМИЙ И ОЛОВО В БИОСФЕРАТА - БИОАКУМУЛАЦИЯ НА КАДМИЙ И ОЛОВО В ОРГАНИЗМА НА МЛАДИ ПРЕЖИВНИ ЖИВОТНИ ОТ АНТРОПОГЕННИ ЕКОСИСТЕМИ С ПОВИШЕН ТЕХНОГЕНЕН КЛАРК

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    The technogenic Clarc of lead (Pb) and cadmium (Cd) from the upper soil layer and the forage plants in an industrially polluted region, so as the Pb and Cd input in the organism of young lambs and kid by the synthesis of secondary biological production have been investigated. For the synthesis of 1 kg secondary production in the organism of lambs, the input of Pb with the food and drinking water is 6.44 mg and 2.46 mg Cd and in the kid- organism- 21.41 mg Pb and 5.29 mg Cd. The obtained production in conditions of increased technogenic Clarc is with higher content of Pb and Cd, according the maximal admissible levels (EC- regulation 466/2001).Изследвани са технологичният кларк на олово и кадмий в горе н слой на почва и фуражи в индустриално замърсен район, както и постъпленията на олово и кадмий в организма на млади агнета и ярета при синтеза на вторична биологична продукция. За синтеза на 1 kg вторична продукция при агнета, постъпленията от фуража и питейната вода са 6,44 mg олово и 2,46 mg кадмий а в организма на яретата – съответно 21,41 mg олово и 5,29 mg кадмий. Получената в условията на повишен техногенен кларк продукция е с по високо съдържание на олово и кадмий спрямо пределнодопустимите концинтрации (EC regulation 466/2001)

    Beam Based Alignment of Interaction Region Magnets

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    In conventional beam based alignment (BBA) procedures, the relative alignment of a quadrupole to a nearby beam position monitor is determined by finding a beam position in the quadrupole at which the closed orbit does not change when the quadrupole field is varied. The final focus magnets of the interaction regions (IR) of circular colliders often have some specialized properties that make it difficult to perform conventional beam based alignment procedures. At the HERA interaction points, for example, these properties are: (a) The quadrupoles are quite strong and long. Therefore a thin lens approximation is quite imprecise. (b) The effects of angular magnet offsets become significant. (c) The possibilities to steer the beam are limited as long as the alignment is not within specifications. (d) The beam orbit has design offsets and design angles with respect to the axis of the low-beta quadrupoles. (e) Often quadrupoles do not have a beam position monitor in their vicinity. Here we present a beam based alignment procedure that determines the relative offset of the closed orbit from a quadrupole center without requiring large orbit changes or monitors next to the quadrupole. Taking into account the alignment angle allows us to reduce the sensitivity to optical errors by one to two orders of magnitude. We also show how the BBA measurements of all IR quadrupoles can be used to determine the global position of the magnets. The sensitivity to errors of this method is evaluated and its applicability to HERA is shown

    Educational paper: Imaging child abuse: the bare bones

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    Fractures are reported to be the second most common findings in child abuse, after skin lesions such as bruises and contusions. This makes careful interpretation of childhood fractures in relation to the provided clinical history important. In this literature review, we address imaging techniques and the prevailing protocols as well as fractures, frequently seen in child abuse, and the differential diagnosis of these fractures. The use of a standardised protocol in radiological imaging is stressed, as adherence to the international guidelines has been consistently poor. As fractures are a relatively common finding in childhood and interpretation is sometimes difficult, involvement of a paediatric radiologist is important if not essential. Adherence to international guidelines necessitates review by experts and is therefore mandatory. As in all clinical differential diagnoses, liaison between paediatricians and paediatric radiologists in order to obtain additional clinical information or even better having joint review of radiological studies will improve diagnostic accuracy. It is fundamental to keep in mind that the diagnosis of child abuse can never be solely based on radiological imaging but always on a combination of clinical, investigative and social findings. The quality and interpretation, preferably by a paediatric radiologist, of radiographs is essential in reaching a correct diagnosis in cases of suspected child abuse
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