Equilibrium ion distribution in the presence of clearing electrodes and its influence on electron dynamics

Here we compute the ion distribution produced by an electron beam when ion-clearing electrodes are installed. This ion density is established as an equilibrium between gas ionization and ion clearing. The transverse ion distributions are shown to strongly peak in the beam's center, producing very nonlinear forces on the electron beam. We will analyze perturbations to the beam properties by these nonlinear fields. To obtain reasonable simulation speeds, we develop fast algorithms that take advantage of adiabatic invariants and scaling properties of Maxwell's equations and the Lorentz force. Our results are very relevant for high current Energy Recovery Linacs, where ions are produced relatively quickly, and where clearing gaps in the electron beam cannot easily be used for ion elimination. The examples in this paper therefore use parameters of the Cornell Energy Recovery Linac project. For simplicity we only consider the case of a circular electron beam of changing diameter. However, we parameterize this model to approximate non-round beams well. We find suitable places for clearing electrodes and compute the equilibrium ion density and its effect on electron-emittance growth and halo development. We find that it is not sufficient to place clearing electrodes only at the minimum of the electron beam potential where ions are accumulated

Dynamical analysis of S&P500 momentum

The dynamics of the S&P500 price signal is studied using a moving average technique. Particular attention is paid to intersections of two moving averages with different time horizons. The distributions of the slopes and angle between two moving averages at intersections is analyzed, as well as that of the waiting times between intersections. In addition, the distribution of maxima and minima in the moving average signal is investigated. In all cases, persistent patterns are observed in these probability measures and it is suggested that such variables be considered for better analysis and possible prediction of the trends of the signal.Comment: 17 pages, 9 figures; to be published in Physica

Localization of bosonic atoms by fermionic impurities in a 3d optical lattice

We observe a localized phase of ultracold bosonic quantum gases in a 3-dimensional optical lattice induced by a small contribution of fermionic atoms acting as impurities in a Fermi-Bose quantum gas mixture. In particular we study the dependence of this transition on the fermionic 40K impurity concentration by a comparison to the corresponding superfluid to Mott insulator transition in a pure bosonic 87Rb gas and find a significant shift in the transition parameter. The observed shift is larger than expected based on a mean-field argument, which is a strong indication that disorder-related effects play a significant role.Comment: 4 pages, 4 figure

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation

The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of them reported here for the first time) provide detailed atomic resolution snapshots along the activation coordinate. The prime event is the covalent binding of the substrate pyruvate to the side chain of cysteine 221, thus forming a thiohemiketal. This reaction causes the shift of a neighbouring amino acid, which eventually leads to the rigidification of two otherwise flexible loops, where one of the loops provides two histidine residues necessary to complete the enzymatically competent active site architecture. The structural data are complemented and supported by kinetic investigations and binding studies and provide a consistent picture of the structural changes, which occur upon enzyme activation

["In der Jungfernheide hinterm Pulvermagazin frequens"].

Journal ArticleWe provide a detailed description of an interleaved and heavily annotated copy of Florae Berolinensis Prodromus, a flora of Berlin published by the German apothecary and botanist Karl Ludwig Willdenow in 1787, which today is preserved at the Staatsbibliothek zu Berlin – Preußischer Kulturbesitz. We demonstrate that this is the copy that the author himself used and carried with him during his botanical excursions in and around Berlin to prepare a second edition of the work. By analyzing this document as paper technology, we reveal that even seemingly trifling aspects of its material organization enabled far-reaching biological research agendas that were not originally intended. The hybrid form of manuscript and printed book, used in field excursions, enabled a kind of natural-historical observation that was at once detailed and bound by strict (Linnaean) convention, a combination that inadvertently opened new research questions and suggested new objects of research. We thereby contribute to an understanding of the history of natural history that goes beyond the history of ideas and the intended uses of techniques, giving an example of how routine work on paper within a scientific tradition could generate innovation

Cultural Competency in USU Extension: Impact of Professional Development for Latino Outreach Programs

In response to the growing Latino population in Utah, USU Extension faculty participated in trainings to build their cultural competency and engage with Latino audiences. The professional development series were attended by 186 Extension professionals. A 2021 follow-up study reported that 52% of respondents who participated in the training are currently engaging in Latino outreach programs

Leydig cells express neural cell adhesion molecules in vivo and in vitro

The neural cell adhesion molecule (NCAM) polypeptides are expressed by numerous tissues during embryonic development, where they are involved in cell-cell interactions. In the adult, NCAM expression is confined to a few cell types, including neurons and peptide-hormone-producing cells. Here we demonstrate that the Leydig cells of the adult rat, mouse, and hamster testes express NCAM as well. Western blotting showed that an NCAM of approximately 120 kDa was present in the adult testes of all three species investigated. This form was also found in freshly isolated mouse Leydig cells and in Leydig cells after 2 days in culture. After 4 days in culture, mouse Leydig cells expressed additional NCAM isoforms of approximately 140 and 180 kDa, indicating changes in alternative splicing of NCAM primary transcripts. Also, NCAM mRNA of all isoforms, as detected by S1-nuclease protection assays, increased with time in culture. The expression of the cell adhesion molecule NCAM by adult Leydig cells may explain the aggregation of Leydig cells in clusters in rodent testes, which could be a prerequisite for functional coordination of groups of Leydig cells. Furthermore, the presence of this neural and endocrine marker may indicate a closer relationship between Leydig cells and neural and peptide-hormone-producing cells than is considered to exist at the present time