SAEM Response to the National Institutes of Health request for information: Future directions in violence against women research

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A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine

<p>Abstract</p> <p>Background</p> <p>In recent years, the completion of the Human Genome Project and other rapid advances in genomics have led to increasing anticipation of an era of genomic and personalized medicine, in which an individual's health is optimized through the use of all available patient data, including data on the individual's genome and its downstream products. Genomic and personalized medicine could transform healthcare systems and catalyze significant reductions in morbidity, mortality, and overall healthcare costs.</p> <p>Discussion</p> <p>Critical to the achievement of more efficient and effective healthcare enabled by genomics is the establishment of a robust, nationwide clinical decision support infrastructure that assists clinicians in their use of genomic assays to guide disease prevention, diagnosis, and therapy. Requisite components of this infrastructure include the standardized representation of genomic and non-genomic patient data across health information systems; centrally managed repositories of computer-processable medical knowledge; and standardized approaches for applying these knowledge resources against patient data to generate and deliver patient-specific care recommendations. Here, we provide recommendations for establishing a national decision support infrastructure for genomic and personalized medicine that fulfills these needs, leverages existing resources, and is aligned with the <it>Roadmap for National Action on Clinical Decision Support </it>commissioned by the U.S. Office of the National Coordinator for Health Information Technology. Critical to the establishment of this infrastructure will be strong leadership and substantial funding from the federal government.</p> <p>Summary</p> <p>A national clinical decision support infrastructure will be required for reaping the full benefits of genomic and personalized medicine. Essential components of this infrastructure include standards for data representation; centrally managed knowledge repositories; and standardized approaches for leveraging these knowledge repositories to generate patient-specific care recommendations at the point of care.</p

AMERICA\u27S SYSTEMATICS COLLECTIONS: A NATIONAL PLAN

America\u27s Systematics Collections: A National Plan\u27\u27 is a report to the nation\u27s systematics collections community, and includes a National Plan for the recognition and development of systematics coilections as an important national resource in the United States. The report states the goals of the systematics collections commnnity, and documents the importance of systematics coliections to science, society and education. The problems of the systematics collections community are identified and discussed. Recommendations are presented that, if implemented, could permit the systematics coiiections community to achieve its goals; the recommendations are reiterated within a framework of prioritiei. Eitimated new Support required by the systematics coilections community for the next five years is $63,217,920. The Association of Systematics Collections has been charged with distribution and implementation of the National Plan. This report is addressed principally to systematists concemed with the nature and quality of America\u27s systematics collections as a national resource. The report describes and recommends ways whereby systematists and others responsible for tbe care and management of systematics coiiections can develop their collections into a more effective resource responsive to the needs of science, applied science and society. As part of a national effort to this end by concerned systematists, appropriate steps should be taken to enlist the aid of the public and agencies of the public to bring about major improvements in financial support for collections. During the past several years, there has been growing concern about systematics collections, their condition, their capacities to provide an increasingly diverse spectrum of Services, and the quality of their essential partnership with systematic biology. This report is the outgrowth of a number of previous studies and reports concerning the present status of systematics collections and their prospects for the future

The new case for increased railroad rates; abstracts of testimony and arguments presented to the Interstate commerce commission,

"The presentation of the case on behalf of the carriers was in charge of a committee of railroad presidents, comprised of Daniel Willard (chairman), president, Baltimore and Ohio railroad company, Samuel Rea, president, Pennsylvania railroad company, A. H. Smith, president, New York central lines."Mode of access: Internet

Comparison of NACA 65-series compressor-blade pressure distributions and performance in a rotor and in cascade /

The comparison indicated that cascade data accurately predicted the turning angle and blade pressure distribution obtained in the compressor at design conditions. At other than design angle of attack, large differences, probably due to secondary flows, were observed near the inner casing.An investigation has been conducted to compare the performance of NACA 65-series compressor blades in two-dimensional cascade with that in an axial-flow compressor. The entering and leaving flow velocities, pressure rise, and the pressure distribution on the rotating blades were measured at three radial stations of a free-vortex rotor. The blade pressure distributions were obtained by the use of a mercury-seal pressure-transfer device. The data obtained were compared with similar data for the same blade sections obtained from a two-dimensional porous-wall cascade tunnel."November 16, 1951."Includes bibliographical references (p. 13).The comparison indicated that cascade data accurately predicted the turning angle and blade pressure distribution obtained in the compressor at design conditions. At other than design angle of attack, large differences, probably due to secondary flows, were observed near the inner casing.An investigation has been conducted to compare the performance of NACA 65-series compressor blades in two-dimensional cascade with that in an axial-flow compressor. The entering and leaving flow velocities, pressure rise, and the pressure distribution on the rotating blades were measured at three radial stations of a free-vortex rotor. The blade pressure distributions were obtained by the use of a mercury-seal pressure-transfer device. The data obtained were compared with similar data for the same blade sections obtained from a two-dimensional porous-wall cascade tunnel.Mode of access: Internet