2,290 research outputs found
Decoherent Histories Quantum Mechanics with One 'Real' Fine-Grained History
Decoherent histories quantum theory is reformulated with the assumption that
there is one "real" fine-grained history, specified in a preferred complete set
of sum-over-histories variables. This real history is described by embedding it
in an ensemble of comparable imagined fine-grained histories, not unlike the
familiar ensemble of statistical mechanics. These histories are assigned
extended probabilities, which can sometimes be negative or greater than one. As
we will show, this construction implies that the real history is not completely
accessible to experimental or other observational discovery. However,
sufficiently and appropriately coarse-grained sets of alternative histories
have standard probabilities providing information about the real fine-grained
history that can be compared with observation. We recover the probabilities of
decoherent histories quantum mechanics for sets of histories that are recorded
and therefore decohere. Quantum mechanics can be viewed as a classical
stochastic theory of histories with extended probabilities and a well-defined
notion of reality common to all decoherent sets of alternative coarse-grained
histories.Comment: 11 pages, one figure, expanded discussion and acknowledgment
Beyond the Hoax: A Response to Emily A. Schultz
I am grateful to the editors of Reviews in Anthropology for giving me the opportunity
to respond to Emily Schultz’s review (2010) of my book Beyond the Hoax: Science,
Philosophy and Culture (2008). I shall begin by briefly correcting several of Schultz’s
misrepresentations of my ideas. I shall then endeavor to address the intellectually
interesting issues that she raises
Effect of Intensive Versus Standard Blood Pressure Control on Stroke Subtypes
In the SPRINT (Systolic Blood Pressure Intervention Trial), the number of strokes did not differ significantly by treatment group. However, stroke subtypes have heterogeneous causes that could respond differently to intensive blood pressure control. SPRINT participants (N=9361) were randomized to target systolic blood pressures of \u3c120 mm Hg (intensive treatment) compared with \u3c140 mm Hg (standard treatment). We compared incident hemorrhage, cardiac embolism, large- and small-vessel infarctions across treatment arms. Participants randomized to the intensive arm had mean systolic blood pressures of 121.4 mm Hg in the intensive arm (N=4678) and 136.2 mm Hg in the standard arm (N=4683) at one year. Sixty-nine strokes occurred in the intensive arm and 78 in the standard arm when SPRINT was stopped. The breakdown of stroke subtypes across treatment arms included hemorrhagic (intensive treatment, n=6, standard treatment, n=7) and ischemic stroke subtypes (large artery atherosclerosis: intensive treatment n=11, standard treatment, n=13; cardiac embolism: intensive treatment n=11, standard treatment n=15; small artery occlusion: intensive treatment n=8, standard treatment n=8; other ischemic stroke: intensive treatment n=3, standard treatment n=1). Fewer strokes occurred among participants without prior cardiovascular disease in the intensive (n=43) than the standard arm (n=61), but the difference did not reach predefined statistical significance level of 0.05 (P=0.09). The interaction between baseline cardiovascular risk factor status and treatment arm on stroke risk did not reach significance (P=0.05). Similar numbers of stroke subtypes occurred in the intensive BP control and standard control arms of SPRINT
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SAEM Response to the National Institutes of Health request for information: Future directions in violence against women research
No abstrac
Whither the genus Caldicellulosiruptor and the order Thermoanaerobacterales: phylogeny, taxonomy, ecology, and phenotype
The order Thermoanaerobacterales currently consists of fermentative anaerobic bacteria, including the genus Caldicellulosiruptor. Caldicellulosiruptor are represented by thirteen species; all, but one, have closed genome sequences. Interest in these extreme thermophiles has been motivated not only by their high optimal growth temperatures (≥70°C), but also by their ability to hydrolyze polysaccharides including, for some species, both xylan and microcrystalline cellulose. Caldicellulosiruptor species have been isolated from geographically diverse thermal terrestrial environments located in New Zealand, China, Russia, Iceland and North America. Evidence of their presence in other terrestrial locations is apparent from metagenomic signatures, including volcanic ash in permafrost. Here, phylogeny and taxonomy of the genus Caldicellulosiruptor was re-examined in light of new genome sequences. Based on genome analysis of 15 strains, a new order, Caldicellulosiruptorales, is proposed containing the family Caldicellulosiruptoraceae, consisting of two genera, Caldicellulosiruptor and Anaerocellum. Furthermore, the order Thermoanaerobacterales also was re-assessed, using 91 genome-sequenced strains, and should now include the family Thermoanaerobacteraceae containing the genera Thermoanaerobacter, Thermoanaerobacterium, Caldanaerobacter, the family Caldanaerobiaceae containing the genus Caldanaerobius, and the family Calorimonaceae containing the genus Calorimonas. A main outcome of ANI/AAI analysis indicates the need to reclassify several previously designated species in the Thermoanaerobacterales and Caldicellulosiruptorales by condensing them into strains of single species. Comparative genomics of carbohydrate-active enzyme inventories suggested differentiating phenotypic features, even among strains of the same species, reflecting available nutrients and ecological roles in their native biotopes
Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector
Background: Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Ga-mediated GTP hydrolysis (‘‘GTPase-accelerating proteins’’ or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Ga GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specific effector. However, more recent data from mammals and Drosophila imply that, in vivo, RGS14 may instead be an effector of Ras.Methodology/Principal Findings: Full-length and truncated forms of purified RGS14 protein were found to bind indiscriminately in vitro to both Rap- and Ras-family GTPases, consistent with prior literature reports. In stark contrast, however, we found that in a cellular context RGS14 selectively binds to activated H-Ras and not to Rap isoforms. Co- transfection / co-immunoprecipitation experiments demonstrated the ability of full-length RGS14 to assemble a multiprotein complex with components of the ERK MAPK pathway in a manner dependent on activated H-Ras. Small interfering RNA-mediated knockdown of RGS14 inhibited both nerve growth factor- and basic fibrobast growth factor- mediated neuronal differentiation of PC12 cells, a process which is known to be dependent on Ras-ERK signaling.Conclusions/Significance: In cells, RGS14 facilitates the formation of a selective Ras?GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate H-Ras-dependent neuritogenesis. This cellular function for RGS14 is similar but distinct from that recently described for its closely-related paralogue, RGS12, which shares the tandem Ras- binding domain architecture with RGS14
1953: Abilene Christian College Bible Lectures - Full Text
Delivered in the Auditorium of Abilene Christian College,
February, 1953
ABILENE, TEXAS
PRICE: $3.00
firm foundation publishing house
Box 77 Austin 01, Texa
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A comparison of methods for the measurement of the absorption coefficient in natural waters
In the spring of 1992 an optical closure experiment was conducted at Lake
Pend Oreille, Idaho. A primary objective of the experiment was to compare techniques
for the measurement of the spectral absorption coefficient and other inherent optical
properties of natural waters. Daily averages of absorption coefficients measured using
six methods are compared at wavelengths of 456, 488, and 532 nm. Overall agreement
was within 40% at 456 nm and improved with increasing wavelength to 25% at 532 nm.
These absorption measurements were distributed over the final 9 days of the
experiment, when bio-optical conditions in Lake Pend Oreille (as indexed by the beam
attenuation coefficient cp(660) and chlorophyll a fluorescence profiles) were
representative of those observed throughout the experiment. However, profiles of
stimulated chlorophyll a fluorescence and beam transmission showed that bio-optical
properties in the lake varied strongly on all time and space scales. Therefore
environmental variability contributed significantly to deviations between daily mean
absorption coefficients measured using the different techniques
Peasant settlers and the ‘civilizing mission’ in Russian Turkestan, 1865-1917
This article provides an introduction to one of the lesser-known examples of European settler colonialism, the settlement of European (mainly Russian and Ukrainian) peasants in Southern Central Asia (Turkestan) in the late nineteenth and early twentieth centuries. It establishes the legal background and demographic impact of peasant settlement, and the role played by the state in organising and encouraging it. It explores official attitudes towards the settlers (which were often very negative), and their relations with the local Kazakh and Kyrgyz population. The article adopts a comparative framework, looking at Turkestan alongside Algeria and Southern Africa, and seeking to establish whether paradigms developed in the study of other settler societies (such as the ‘poor white’) are of any relevance in understanding Slavic peasant settlement in Turkestan. It concludes that there are many close parallels with European settlement in other regions with large indigenous populations, but that racial ideology played a much less important role in the Russian case compared to religious divisions and fears of cultural backsliding. This did not prevent relations between settlers and the ‘native’ population deteriorating markedly in the years before the First World War, resulting in large-scale rebellion in 1916
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